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Marchiafawa bignami disease possibly related to consumption of a locally brewed alcoholic beverage: Report of two cases.

Rawat JP, Pinto C, Kulkarni KS, Muthusamy MA, Dave MD - Indian J Psychiatry (2014)

Bottom Line: In radiological point of view typically the corpus callosum is affected, with involvement of the body, genu, and splenium in order of occurrence.Occasionally the entire callosum may be also involved.Clinical presentation varies from case to case.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Jagjivan Ram Hospital, Mumbai, Maharashtra, India.

ABSTRACT
Marchiafava Bignami disease is a rare toxic disease seen mostly in chronic alcoholics, resulting in progressive demyelination and necrosis of the corpus callosum. Initially it was thought to be specific to individuals in central Italy, consuming large amounts of Chianti red wine; however, alcoholic beverages worldwide are presently implicated. In our case series of two cases, locally made "illicit" liquor (Mahuwa Alcohol) could be the causative factor. In radiological point of view typically the corpus callosum is affected, with involvement of the body, genu, and splenium in order of occurrence. Occasionally the entire callosum may be also involved. Clinical presentation varies from case to case.

No MeSH data available.


Related in: MedlinePlus

Acute demyelination in Marchiafava bignami syndrome: Axial DW images (a and b) show symmetric hyperintensities in the splenium of corpus callosum, which show reduced diffusivity on the ADC maps
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Figure 1: Acute demyelination in Marchiafava bignami syndrome: Axial DW images (a and b) show symmetric hyperintensities in the splenium of corpus callosum, which show reduced diffusivity on the ADC maps

Mentions: Patient was referred to our hospital for fitness. He was admitted. Last consumption was day prior to admission and he developed tremors next day. Routine investigations and neurological examination were normal. MMSE was 21/30. He was started on anti-withdrawal line of management with Inj. Thiamine (100 mg) OD, Tab. Multivitamin BD and Tab. Lorazepam 10 mg in divided doses. Repeat MRI brain showed hyper intense signal alterations involving posterior body and splenium, as well as anterior body and genu of the corpus callosum. This represent progressive demyelination and necrosis of the corpus callosum [Figure 1]. All these characteristic findings confirmed the diagnosis of MBD.


Marchiafawa bignami disease possibly related to consumption of a locally brewed alcoholic beverage: Report of two cases.

Rawat JP, Pinto C, Kulkarni KS, Muthusamy MA, Dave MD - Indian J Psychiatry (2014)

Acute demyelination in Marchiafava bignami syndrome: Axial DW images (a and b) show symmetric hyperintensities in the splenium of corpus callosum, which show reduced diffusivity on the ADC maps
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927250&req=5

Figure 1: Acute demyelination in Marchiafava bignami syndrome: Axial DW images (a and b) show symmetric hyperintensities in the splenium of corpus callosum, which show reduced diffusivity on the ADC maps
Mentions: Patient was referred to our hospital for fitness. He was admitted. Last consumption was day prior to admission and he developed tremors next day. Routine investigations and neurological examination were normal. MMSE was 21/30. He was started on anti-withdrawal line of management with Inj. Thiamine (100 mg) OD, Tab. Multivitamin BD and Tab. Lorazepam 10 mg in divided doses. Repeat MRI brain showed hyper intense signal alterations involving posterior body and splenium, as well as anterior body and genu of the corpus callosum. This represent progressive demyelination and necrosis of the corpus callosum [Figure 1]. All these characteristic findings confirmed the diagnosis of MBD.

Bottom Line: In radiological point of view typically the corpus callosum is affected, with involvement of the body, genu, and splenium in order of occurrence.Occasionally the entire callosum may be also involved.Clinical presentation varies from case to case.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Jagjivan Ram Hospital, Mumbai, Maharashtra, India.

ABSTRACT
Marchiafava Bignami disease is a rare toxic disease seen mostly in chronic alcoholics, resulting in progressive demyelination and necrosis of the corpus callosum. Initially it was thought to be specific to individuals in central Italy, consuming large amounts of Chianti red wine; however, alcoholic beverages worldwide are presently implicated. In our case series of two cases, locally made "illicit" liquor (Mahuwa Alcohol) could be the causative factor. In radiological point of view typically the corpus callosum is affected, with involvement of the body, genu, and splenium in order of occurrence. Occasionally the entire callosum may be also involved. Clinical presentation varies from case to case.

No MeSH data available.


Related in: MedlinePlus