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Plasma homocysteine levels in depression and schizophrenia in South Indian Tamilian population.

Narayan SK, Verman A, Kattimani S, Ananthanarayanan PH, Adithan C - Indian J Psychiatry (2014)

Bottom Line: Hyperhomocysteinemia has been associated with psychiatric diseases in non-Indian populations.Hcys levels were determined using automated chemiluminiscence immunoassay (74-76).In Tamilian population, schizophrenia and depression are associated with total plasma Hcys levels which correlated with the duration and severity of psychosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Neurology, Pharmacology and Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

ABSTRACT

Context: Hyperhomocysteinemia has been associated with psychiatric diseases in non-Indian populations.

Objectives: We aimed to determine if total plasma Homocysteine (Hcys) is associated with schizophrenia or depression in South Indian Tamil patients and if so, to correlate their severity and phenomenology to Hcys levels.

Settings and design: 40 patients each with schizophrenia and depression and 40 healthy controls were recruited from the psychiatry department of a quaternary referral centre. Association between Hcys and psychiatric disorders was determined using a Case- control design. Hcys levels were correlated with age, gender and severity and duration of the disease by appropriate statistical methods using SPSS17.

Materials and methods: Schizophrenia and depression were defined using ICD10 DCR version. Severity of depression was assessed by Hamilton Depression Rating Scale and that of schizophrenia using Positive and Negative Schizophrenia scales (PANSS). Hcys levels were determined using automated chemiluminiscence immunoassay (74-76).

Statistical analysis: Differences between the mean values of plasma homocysteine levels among schizophrenia, depression and control groups were compared using analysis of variants. The association between the severity and duration of schizophrenia and depression and the plasma homocysteine levels were determine using Pearson correlation.

Conclusions: In Tamilian population, schizophrenia and depression are associated with total plasma Hcys levels which correlated with the duration and severity of psychosis.

No MeSH data available.


Related in: MedlinePlus

Correlation of total plasma Hcys with severity of depression HDRS (Hamilton Depression Rating Scale scores). There is a significant association between HDRS score and plasma Hcys level
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Figure 4: Correlation of total plasma Hcys with severity of depression HDRS (Hamilton Depression Rating Scale scores). There is a significant association between HDRS score and plasma Hcys level

Mentions: The mean total plasma Hcys level was significantly higher in the depressed versus the control in men (P=0.04) but not in women (P=0.313). The plasma Hcys levels increased significantly with the Hamilton Depression Rating Score in a linear fashion (P<0.001) [Figure 4] and also with the duration of the depression (R=0.7; P<0.001) [Figure 5]. However, on subgroup analysis, the rise in Hcys levels and its linear trend with HDRS scores was confined to the severely depressed group (n=24, HDRS>24) (R=0.94; P<0.001) in contrast with the moderately depressed group (n=16, HDRS<25) (R=0.35; P=0.2).


Plasma homocysteine levels in depression and schizophrenia in South Indian Tamilian population.

Narayan SK, Verman A, Kattimani S, Ananthanarayanan PH, Adithan C - Indian J Psychiatry (2014)

Correlation of total plasma Hcys with severity of depression HDRS (Hamilton Depression Rating Scale scores). There is a significant association between HDRS score and plasma Hcys level
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927245&req=5

Figure 4: Correlation of total plasma Hcys with severity of depression HDRS (Hamilton Depression Rating Scale scores). There is a significant association between HDRS score and plasma Hcys level
Mentions: The mean total plasma Hcys level was significantly higher in the depressed versus the control in men (P=0.04) but not in women (P=0.313). The plasma Hcys levels increased significantly with the Hamilton Depression Rating Score in a linear fashion (P<0.001) [Figure 4] and also with the duration of the depression (R=0.7; P<0.001) [Figure 5]. However, on subgroup analysis, the rise in Hcys levels and its linear trend with HDRS scores was confined to the severely depressed group (n=24, HDRS>24) (R=0.94; P<0.001) in contrast with the moderately depressed group (n=16, HDRS<25) (R=0.35; P=0.2).

Bottom Line: Hyperhomocysteinemia has been associated with psychiatric diseases in non-Indian populations.Hcys levels were determined using automated chemiluminiscence immunoassay (74-76).In Tamilian population, schizophrenia and depression are associated with total plasma Hcys levels which correlated with the duration and severity of psychosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Neurology, Pharmacology and Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

ABSTRACT

Context: Hyperhomocysteinemia has been associated with psychiatric diseases in non-Indian populations.

Objectives: We aimed to determine if total plasma Homocysteine (Hcys) is associated with schizophrenia or depression in South Indian Tamil patients and if so, to correlate their severity and phenomenology to Hcys levels.

Settings and design: 40 patients each with schizophrenia and depression and 40 healthy controls were recruited from the psychiatry department of a quaternary referral centre. Association between Hcys and psychiatric disorders was determined using a Case- control design. Hcys levels were correlated with age, gender and severity and duration of the disease by appropriate statistical methods using SPSS17.

Materials and methods: Schizophrenia and depression were defined using ICD10 DCR version. Severity of depression was assessed by Hamilton Depression Rating Scale and that of schizophrenia using Positive and Negative Schizophrenia scales (PANSS). Hcys levels were determined using automated chemiluminiscence immunoassay (74-76).

Statistical analysis: Differences between the mean values of plasma homocysteine levels among schizophrenia, depression and control groups were compared using analysis of variants. The association between the severity and duration of schizophrenia and depression and the plasma homocysteine levels were determine using Pearson correlation.

Conclusions: In Tamilian population, schizophrenia and depression are associated with total plasma Hcys levels which correlated with the duration and severity of psychosis.

No MeSH data available.


Related in: MedlinePlus