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Voxelwise meta-analysis of gray matter anomalies in progressive supranuclear palsy and Parkinson's disease using anatomic likelihood estimation.

Shao N, Yang J, Li J, Shang HF - Front Hum Neurosci (2014)

Bottom Line: GM reductions were present in the bilateral thalamus, basal ganglia, midbrain, insular cortex and inferior frontal gyrus, and left precentral gyrus and anterior cingulate gyrus in PSP.Atrophy of GM was concentrated in the bilateral middle and inferior frontal gyrus, precuneus, left precentral gyrus, middle temporal gyrus, right superior parietal lobule, and right cuneus in PD.Subtraction meta-analysis indicated that GM volume was lesser in the bilateral midbrain, thalamus, and insula in PSP compared with that in PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, West China Hospital, Sichuan University Chengdu, China.

ABSTRACT
Numerous voxel-based morphometry (VBM) studies on gray matter (GM) of patients with progressive supranuclear palsy (PSP) and Parkinson's disease (PD) have been conducted separately. Identifying the different neuroanatomical changes in GM resulting from PSP and PD through meta-analysis will aid the differential diagnosis of PSP and PD. In this study, a systematic review of VBM studies of patients with PSP and PD relative to healthy control (HC) in the Embase and PubMed databases from January 1995 to April 2013 was conducted. The anatomical distribution of the coordinates of GM differences was meta-analyzed using anatomical likelihood estimation. Separate maps of GM changes were constructed and subtraction meta-analysis was performed to explore the differences in GM abnormalities between PSP and PD. Nine PSP studies and 24 PD studies were included. GM reductions were present in the bilateral thalamus, basal ganglia, midbrain, insular cortex and inferior frontal gyrus, and left precentral gyrus and anterior cingulate gyrus in PSP. Atrophy of GM was concentrated in the bilateral middle and inferior frontal gyrus, precuneus, left precentral gyrus, middle temporal gyrus, right superior parietal lobule, and right cuneus in PD. Subtraction meta-analysis indicated that GM volume was lesser in the bilateral midbrain, thalamus, and insula in PSP compared with that in PD. Our meta-analysis indicated that PSP and PD shared a similar distribution of neuroanatomical changes in the frontal lobe, including inferior frontal gyrus and precentral gyrus, and that atrophy of the midbrain, thalamus, and insula are neuroanatomical markers for differentiating PSP from PD.

No MeSH data available.


Related in: MedlinePlus

Gray matter volume changes betweeen different groups. PSP, gray matter decreases in patients with progressive supranuclear palsy relative to healthy control; PD, gray matter decreases in patients with Parkinson's disease relative to healthy control; PSP < PD, diminished gray matter volume in progressive supranuclear palsy patients relative to Parkinson's disease patients. Significance thresholded with a false discovery rate at P < 0.05 and a cluster extent threshold of 100 voxels; z, z coordinates in Talairach space; L, left; R, right.
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Figure 2: Gray matter volume changes betweeen different groups. PSP, gray matter decreases in patients with progressive supranuclear palsy relative to healthy control; PD, gray matter decreases in patients with Parkinson's disease relative to healthy control; PSP < PD, diminished gray matter volume in progressive supranuclear palsy patients relative to Parkinson's disease patients. Significance thresholded with a false discovery rate at P < 0.05 and a cluster extent threshold of 100 voxels; z, z coordinates in Talairach space; L, left; R, right.

Mentions: We identified 32 studies in the database searches (Figure 1) including nine PSP-HC articles (Brenneis et al., 2004; Cordato et al., 2005; Boxer et al., 2006; Padovani et al., 2006; Agosta et al., 2010; Lehericy et al., 2010; Takahashi et al., 2011; Ghosh et al., 2012; Giordano et al., 2013). One hundred and fourty-five PSP patients and 217 HC were included in this study and a total of 104 foci with reduced GMV were reported. The main characteristics of the included participants are presented in Table 1. Thirty PSP patients from two studies had mild cognitive impairment (Padovani et al., 2006; Takahashi et al., 2011). GM reduction was observed in the bilateral thalamus, midbrain, insula, basal ganglia, inferior frontal gyrus, left precentral gyrus, and the left anterior cingulate by using the ALE approach (Figure 2). No increased GMV relative to HC was observed in the brain regions of PSP patients. Similar findings were revealed after excluding two studies conducted on PSP patients with mild cognitive impairment (Padovani et al., 2006; Takahashi et al., 2011) (Supplemental Figure 1).


Voxelwise meta-analysis of gray matter anomalies in progressive supranuclear palsy and Parkinson's disease using anatomic likelihood estimation.

Shao N, Yang J, Li J, Shang HF - Front Hum Neurosci (2014)

Gray matter volume changes betweeen different groups. PSP, gray matter decreases in patients with progressive supranuclear palsy relative to healthy control; PD, gray matter decreases in patients with Parkinson's disease relative to healthy control; PSP < PD, diminished gray matter volume in progressive supranuclear palsy patients relative to Parkinson's disease patients. Significance thresholded with a false discovery rate at P < 0.05 and a cluster extent threshold of 100 voxels; z, z coordinates in Talairach space; L, left; R, right.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927227&req=5

Figure 2: Gray matter volume changes betweeen different groups. PSP, gray matter decreases in patients with progressive supranuclear palsy relative to healthy control; PD, gray matter decreases in patients with Parkinson's disease relative to healthy control; PSP < PD, diminished gray matter volume in progressive supranuclear palsy patients relative to Parkinson's disease patients. Significance thresholded with a false discovery rate at P < 0.05 and a cluster extent threshold of 100 voxels; z, z coordinates in Talairach space; L, left; R, right.
Mentions: We identified 32 studies in the database searches (Figure 1) including nine PSP-HC articles (Brenneis et al., 2004; Cordato et al., 2005; Boxer et al., 2006; Padovani et al., 2006; Agosta et al., 2010; Lehericy et al., 2010; Takahashi et al., 2011; Ghosh et al., 2012; Giordano et al., 2013). One hundred and fourty-five PSP patients and 217 HC were included in this study and a total of 104 foci with reduced GMV were reported. The main characteristics of the included participants are presented in Table 1. Thirty PSP patients from two studies had mild cognitive impairment (Padovani et al., 2006; Takahashi et al., 2011). GM reduction was observed in the bilateral thalamus, midbrain, insula, basal ganglia, inferior frontal gyrus, left precentral gyrus, and the left anterior cingulate by using the ALE approach (Figure 2). No increased GMV relative to HC was observed in the brain regions of PSP patients. Similar findings were revealed after excluding two studies conducted on PSP patients with mild cognitive impairment (Padovani et al., 2006; Takahashi et al., 2011) (Supplemental Figure 1).

Bottom Line: GM reductions were present in the bilateral thalamus, basal ganglia, midbrain, insular cortex and inferior frontal gyrus, and left precentral gyrus and anterior cingulate gyrus in PSP.Atrophy of GM was concentrated in the bilateral middle and inferior frontal gyrus, precuneus, left precentral gyrus, middle temporal gyrus, right superior parietal lobule, and right cuneus in PD.Subtraction meta-analysis indicated that GM volume was lesser in the bilateral midbrain, thalamus, and insula in PSP compared with that in PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, West China Hospital, Sichuan University Chengdu, China.

ABSTRACT
Numerous voxel-based morphometry (VBM) studies on gray matter (GM) of patients with progressive supranuclear palsy (PSP) and Parkinson's disease (PD) have been conducted separately. Identifying the different neuroanatomical changes in GM resulting from PSP and PD through meta-analysis will aid the differential diagnosis of PSP and PD. In this study, a systematic review of VBM studies of patients with PSP and PD relative to healthy control (HC) in the Embase and PubMed databases from January 1995 to April 2013 was conducted. The anatomical distribution of the coordinates of GM differences was meta-analyzed using anatomical likelihood estimation. Separate maps of GM changes were constructed and subtraction meta-analysis was performed to explore the differences in GM abnormalities between PSP and PD. Nine PSP studies and 24 PD studies were included. GM reductions were present in the bilateral thalamus, basal ganglia, midbrain, insular cortex and inferior frontal gyrus, and left precentral gyrus and anterior cingulate gyrus in PSP. Atrophy of GM was concentrated in the bilateral middle and inferior frontal gyrus, precuneus, left precentral gyrus, middle temporal gyrus, right superior parietal lobule, and right cuneus in PD. Subtraction meta-analysis indicated that GM volume was lesser in the bilateral midbrain, thalamus, and insula in PSP compared with that in PD. Our meta-analysis indicated that PSP and PD shared a similar distribution of neuroanatomical changes in the frontal lobe, including inferior frontal gyrus and precentral gyrus, and that atrophy of the midbrain, thalamus, and insula are neuroanatomical markers for differentiating PSP from PD.

No MeSH data available.


Related in: MedlinePlus