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Intravenous albumin infusion is an effective therapy for hyponatremia in patient with malignant ascites.

Jhaveri KD, Chawla A, Xu C, Hazzan A - Indian J Nephrol (2014)

Bottom Line: There are few reports about the treatment of moderate to severe hyponatremia associated with malignant liver metastasis.A 58-year-old female with ascites secondary to metastatic breast cancer was referred to our department with symptomatic hyponatremia (serum sodium concentration of 121 mEq/L).The serum sodium level was corrected slowly over 2 days with intravenous albumin infusion and the patient's symptoms - fatigue, nausea, dizziness and headache improved.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Division of Kidney Diseases and Hypertension, Hofstra North Shore-LIJ School of Medicine, Great Neck, New York, USA.

ABSTRACT
There are few reports about the treatment of moderate to severe hyponatremia associated with malignant liver metastasis. Here, we report using intravenous salt poor albumin infusion to treat hypervolemic cirrhosis related hyponatremia. A 58-year-old female with ascites secondary to metastatic breast cancer was referred to our department with symptomatic hyponatremia (serum sodium concentration of 121 mEq/L). The serum sodium level was corrected slowly over 2 days with intravenous albumin infusion and the patient's symptoms - fatigue, nausea, dizziness and headache improved.

No MeSH data available.


Related in: MedlinePlus

Time course of changes in serum sodium in the patient
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Figure 1: Time course of changes in serum sodium in the patient

Mentions: The patient was treated with 100 ml 25% albumin intravenous infusion every 8 h for 2 days for her symptomatic hyponatremia. She was on fluid restriction to <1200 cc/day and appropriately with sodium restriction to less than 2300 mg/day. Her serum sodium concentration increased to 134 mEq/L over 48 h [Figure 1] and her weakness, anorexia, and headache significantly improved. She was discharged from the hospital with recommendations for fluid restriction. Her serum sodium concentration maintained in the range of 134-140 mEq/L in the next 2 months after her discharge.


Intravenous albumin infusion is an effective therapy for hyponatremia in patient with malignant ascites.

Jhaveri KD, Chawla A, Xu C, Hazzan A - Indian J Nephrol (2014)

Time course of changes in serum sodium in the patient
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927194&req=5

Figure 1: Time course of changes in serum sodium in the patient
Mentions: The patient was treated with 100 ml 25% albumin intravenous infusion every 8 h for 2 days for her symptomatic hyponatremia. She was on fluid restriction to <1200 cc/day and appropriately with sodium restriction to less than 2300 mg/day. Her serum sodium concentration increased to 134 mEq/L over 48 h [Figure 1] and her weakness, anorexia, and headache significantly improved. She was discharged from the hospital with recommendations for fluid restriction. Her serum sodium concentration maintained in the range of 134-140 mEq/L in the next 2 months after her discharge.

Bottom Line: There are few reports about the treatment of moderate to severe hyponatremia associated with malignant liver metastasis.A 58-year-old female with ascites secondary to metastatic breast cancer was referred to our department with symptomatic hyponatremia (serum sodium concentration of 121 mEq/L).The serum sodium level was corrected slowly over 2 days with intravenous albumin infusion and the patient's symptoms - fatigue, nausea, dizziness and headache improved.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Division of Kidney Diseases and Hypertension, Hofstra North Shore-LIJ School of Medicine, Great Neck, New York, USA.

ABSTRACT
There are few reports about the treatment of moderate to severe hyponatremia associated with malignant liver metastasis. Here, we report using intravenous salt poor albumin infusion to treat hypervolemic cirrhosis related hyponatremia. A 58-year-old female with ascites secondary to metastatic breast cancer was referred to our department with symptomatic hyponatremia (serum sodium concentration of 121 mEq/L). The serum sodium level was corrected slowly over 2 days with intravenous albumin infusion and the patient's symptoms - fatigue, nausea, dizziness and headache improved.

No MeSH data available.


Related in: MedlinePlus