Limits...
Medial prefrontal cortex stimulation modulates the processing of conditioned fear.

Guhn A, Dresler T, Andreatta M, Müller LD, Hahn T, Tupak SV, Polak T, Deckert J, Herrmann MJ - Front Behav Neurosci (2014)

Bottom Line: In rats, high-frequency electrical mPFC stimulation has been shown to improve extinction by means of a reduction of amygdala activity.However, so far it is unclear whether stimulation of homologues regions in humans might have similar beneficial effects.Consistent with the hypothesis of a modulated processing of conditioned fear after high-frequency rTMS, the active group showed a reduced CS+/CS- discrimination during extinction learning as evident in FPS as well as in SCR and arousal ratings.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg Würzburg, Germany.

ABSTRACT
The extinction of conditioned fear depends on an efficient interplay between the amygdala and the medial prefrontal cortex (mPFC). In rats, high-frequency electrical mPFC stimulation has been shown to improve extinction by means of a reduction of amygdala activity. However, so far it is unclear whether stimulation of homologues regions in humans might have similar beneficial effects. Healthy volunteers received one session of either active or sham repetitive transcranial magnetic stimulation (rTMS) covering the mPFC while undergoing a 2-day fear conditioning and extinction paradigm. Repetitive TMS was applied offline after fear acquisition in which one of two faces (CS+ but not CS-) was associated with an aversive scream (UCS). Immediate extinction learning (day 1) and extinction recall (day 2) were conducted without UCS delivery. Conditioned responses (CR) were assessed in a multimodal approach using fear-potentiated startle (FPS), skin conductance responses (SCR), functional near-infrared spectroscopy (fNIRS), and self-report scales. Consistent with the hypothesis of a modulated processing of conditioned fear after high-frequency rTMS, the active group showed a reduced CS+/CS- discrimination during extinction learning as evident in FPS as well as in SCR and arousal ratings. FPS responses to CS+ further showed a linear decrement throughout both extinction sessions. This study describes the first experimental approach of influencing conditioned fear by using rTMS and can thus be a basis for future studies investigating a complementation of mPFC stimulation to cognitive behavioral therapy (CBT).

No MeSH data available.


Related in: MedlinePlus

Skin conductance responses (SCR) for CS+ and CS− trials during acquisition, extinction learning on day 1, and extinction recall on day 2, per group, respectively. Depicted are means and standard errors of the mean. Asterisks indicate significant differences (*p < 0.05, ***p < 0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3927128&req=5

Figure 5: Skin conductance responses (SCR) for CS+ and CS− trials during acquisition, extinction learning on day 1, and extinction recall on day 2, per group, respectively. Depicted are means and standard errors of the mean. Asterisks indicate significant differences (*p < 0.05, ***p < 0.001).

Mentions: The final sample for SCR analyses consisted of 47 subjects, n = 26 active (15 women) vs. n = 21 sham group (9 women). The three-way ANOVA revealed significant stimulus [F(1, 45) = 26.28, p < 0.001], phase [F(1.6, 74) = 7.62, p = 0.001] and stimulus × phase interaction effects [F(2, 90) = 14.84, p < 0.001]. Group did not influence main or interaction effects (p > 0.1). Both groups showed successful discrimination during acquisition (p < 0.001). Notably, the sham group still showed the CS+/CS− discrimination sustained during extinction learning [t(20) = 2.11, p = 0.047] while the active group displayed no significant CS+/CS− differences (p > 0.9; Figure 5).


Medial prefrontal cortex stimulation modulates the processing of conditioned fear.

Guhn A, Dresler T, Andreatta M, Müller LD, Hahn T, Tupak SV, Polak T, Deckert J, Herrmann MJ - Front Behav Neurosci (2014)

Skin conductance responses (SCR) for CS+ and CS− trials during acquisition, extinction learning on day 1, and extinction recall on day 2, per group, respectively. Depicted are means and standard errors of the mean. Asterisks indicate significant differences (*p < 0.05, ***p < 0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927128&req=5

Figure 5: Skin conductance responses (SCR) for CS+ and CS− trials during acquisition, extinction learning on day 1, and extinction recall on day 2, per group, respectively. Depicted are means and standard errors of the mean. Asterisks indicate significant differences (*p < 0.05, ***p < 0.001).
Mentions: The final sample for SCR analyses consisted of 47 subjects, n = 26 active (15 women) vs. n = 21 sham group (9 women). The three-way ANOVA revealed significant stimulus [F(1, 45) = 26.28, p < 0.001], phase [F(1.6, 74) = 7.62, p = 0.001] and stimulus × phase interaction effects [F(2, 90) = 14.84, p < 0.001]. Group did not influence main or interaction effects (p > 0.1). Both groups showed successful discrimination during acquisition (p < 0.001). Notably, the sham group still showed the CS+/CS− discrimination sustained during extinction learning [t(20) = 2.11, p = 0.047] while the active group displayed no significant CS+/CS− differences (p > 0.9; Figure 5).

Bottom Line: In rats, high-frequency electrical mPFC stimulation has been shown to improve extinction by means of a reduction of amygdala activity.However, so far it is unclear whether stimulation of homologues regions in humans might have similar beneficial effects.Consistent with the hypothesis of a modulated processing of conditioned fear after high-frequency rTMS, the active group showed a reduced CS+/CS- discrimination during extinction learning as evident in FPS as well as in SCR and arousal ratings.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg Würzburg, Germany.

ABSTRACT
The extinction of conditioned fear depends on an efficient interplay between the amygdala and the medial prefrontal cortex (mPFC). In rats, high-frequency electrical mPFC stimulation has been shown to improve extinction by means of a reduction of amygdala activity. However, so far it is unclear whether stimulation of homologues regions in humans might have similar beneficial effects. Healthy volunteers received one session of either active or sham repetitive transcranial magnetic stimulation (rTMS) covering the mPFC while undergoing a 2-day fear conditioning and extinction paradigm. Repetitive TMS was applied offline after fear acquisition in which one of two faces (CS+ but not CS-) was associated with an aversive scream (UCS). Immediate extinction learning (day 1) and extinction recall (day 2) were conducted without UCS delivery. Conditioned responses (CR) were assessed in a multimodal approach using fear-potentiated startle (FPS), skin conductance responses (SCR), functional near-infrared spectroscopy (fNIRS), and self-report scales. Consistent with the hypothesis of a modulated processing of conditioned fear after high-frequency rTMS, the active group showed a reduced CS+/CS- discrimination during extinction learning as evident in FPS as well as in SCR and arousal ratings. FPS responses to CS+ further showed a linear decrement throughout both extinction sessions. This study describes the first experimental approach of influencing conditioned fear by using rTMS and can thus be a basis for future studies investigating a complementation of mPFC stimulation to cognitive behavioral therapy (CBT).

No MeSH data available.


Related in: MedlinePlus