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Convexity meningiomas enhanced by sodium fluorescein.

da Silva CE, da Silva VD, da Silva JL - Surg Neurol Int (2014)

Bottom Line: SF dural tail enhancement was positive in all cases and histologic analysis evidenced involvement of the dura by tumors.Histologic analysis confirmed dural involvement.SF could represent an universally available fluorescent tool for meningioma surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery and Skull Base Surgery, Hospital Ernesto Dornelles, Brazil.

ABSTRACT

Background: The resection of the meningiomas surrounding the dura is an important goal during the removal of a convexity meningioma. The authors present the first application of sodium fluorescein (SF) as a tool for tumor and dural tail identification in convexity meningiomas.

Methods: Five frontal convexity meningiomas operated on between December 2012 and April 2013 were included. After initial dissection a dose of 1 g of the SF, 20% was injected into a peripheral vein. Tumor and dural tail were removed using the correlation between magnetic resonance imaging (MRI) findings and transoperative SF enhancement.

Results: Simpson Grade 1 removal was obtained in three cases, grade 2 in one atypical meningioma and grade zero in one case. SF dural tail enhancement was positive in all cases and histologic analysis evidenced involvement of the dura by tumors.

Conclusion: SF enhancement was evident in meningiomas and dura surrounding the lesions. Histologic analysis confirmed dural involvement. SF could represent an universally available fluorescent tool for meningioma surgery.

No MeSH data available.


Related in: MedlinePlus

SFd - SF enhanced dura
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Figure 4: SFd - SF enhanced dura

Mentions: A 37-year-old female with headaches showing a meningioma in the right frontal lobe on MRI. Transoperative SF administration enhanced tumor and a surrounding dura [Figures 3 and 4]. On histological examination a transitional meningioma was seen. The dural tail surrounding the meningioma area was involved by the disease. Cytogenetic analysis showed a 22 monosomy.


Convexity meningiomas enhanced by sodium fluorescein.

da Silva CE, da Silva VD, da Silva JL - Surg Neurol Int (2014)

SFd - SF enhanced dura
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927087&req=5

Figure 4: SFd - SF enhanced dura
Mentions: A 37-year-old female with headaches showing a meningioma in the right frontal lobe on MRI. Transoperative SF administration enhanced tumor and a surrounding dura [Figures 3 and 4]. On histological examination a transitional meningioma was seen. The dural tail surrounding the meningioma area was involved by the disease. Cytogenetic analysis showed a 22 monosomy.

Bottom Line: SF dural tail enhancement was positive in all cases and histologic analysis evidenced involvement of the dura by tumors.Histologic analysis confirmed dural involvement.SF could represent an universally available fluorescent tool for meningioma surgery.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery and Skull Base Surgery, Hospital Ernesto Dornelles, Brazil.

ABSTRACT

Background: The resection of the meningiomas surrounding the dura is an important goal during the removal of a convexity meningioma. The authors present the first application of sodium fluorescein (SF) as a tool for tumor and dural tail identification in convexity meningiomas.

Methods: Five frontal convexity meningiomas operated on between December 2012 and April 2013 were included. After initial dissection a dose of 1 g of the SF, 20% was injected into a peripheral vein. Tumor and dural tail were removed using the correlation between magnetic resonance imaging (MRI) findings and transoperative SF enhancement.

Results: Simpson Grade 1 removal was obtained in three cases, grade 2 in one atypical meningioma and grade zero in one case. SF dural tail enhancement was positive in all cases and histologic analysis evidenced involvement of the dura by tumors.

Conclusion: SF enhancement was evident in meningiomas and dura surrounding the lesions. Histologic analysis confirmed dural involvement. SF could represent an universally available fluorescent tool for meningioma surgery.

No MeSH data available.


Related in: MedlinePlus