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Clear cell variant of solid pseudopapillary neoplasm of pancreas diagnosed by fine needle aspiration: A case report and review of the literature.

Canberk S, Elcin BB, Uludokumaci A, Uygun N, Gulsen F - Cytojournal (2013)

Bottom Line: Acinar and rosette-like formations, as well as single neoplastic cells were also observed.An unusual cytologic feature was the presence of large, clear cytoplasmic vacuoles.The diagnosis of SPN was confirmed by characteristic immunocytochemical staining pattern including nuclear staining for β-catenin, cytoplasmic staining for vimentin and lack of reactivity for cytokeratin.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology-Cytology, Istanbul University, CERRAHPASA Medical School, Istanbul, Turkey.

ABSTRACT
Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor of uncertain malignant potential, predominantly affecting young adult females. We report a case of clear cell variant of SPN, which was diagnosed by fine needle aspiration biopsy. The aspirate was highly cellular and exhibited delicate branching papillary structures with central capillaries covered with several layers of plasmacytoid tumor cells. Acinar and rosette-like formations, as well as single neoplastic cells were also observed. An unusual cytologic feature was the presence of large, clear cytoplasmic vacuoles. The diagnosis of SPN was confirmed by characteristic immunocytochemical staining pattern including nuclear staining for β-catenin, cytoplasmic staining for vimentin and lack of reactivity for cytokeratin.

No MeSH data available.


Related in: MedlinePlus

The vacuoles can mimick signet-ring appearance on cell block preparation (H and E, cell block)
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Figure 7: The vacuoles can mimick signet-ring appearance on cell block preparation (H and E, cell block)

Mentions: The material was highly cellular and consisted of a monotonous population of loosely cohesive small to medium-sized, round to cuboidal epithelioid cells exhibiting high nuclear/cytoplasmic ratio, finely granular “salt and pepper” chromatin and nuclear grooves. Pseudopapillary structures with arborizing capillaries and metachromic core on Diff-Quik-stained smears were lined by epithelioid cells. Acinar and rosette-like formations, as well as single neoplastic cells were observed [Figure 1]. The background was clean, but scattered foamy histiocytes were present. Many tumor cells exhibited single or multiple clear cytoplasmic vacuoles, displacing the nucleus [Figures 2 and 3]. The vacuoles were well-defined and variable in size, producing coin-shaped empty spaces in the cytoplasm [Figures 4 and 5]. Necrosis and mitosis were not seen. Coin-shaped vacuoles were mimicking signet-ring appearance on the cell-block [Figures 6 and 7]. Periodic acid-schiff (PAS) and mucicarmine stains were negative on the cell block sections.


Clear cell variant of solid pseudopapillary neoplasm of pancreas diagnosed by fine needle aspiration: A case report and review of the literature.

Canberk S, Elcin BB, Uludokumaci A, Uygun N, Gulsen F - Cytojournal (2013)

The vacuoles can mimick signet-ring appearance on cell block preparation (H and E, cell block)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927077&req=5

Figure 7: The vacuoles can mimick signet-ring appearance on cell block preparation (H and E, cell block)
Mentions: The material was highly cellular and consisted of a monotonous population of loosely cohesive small to medium-sized, round to cuboidal epithelioid cells exhibiting high nuclear/cytoplasmic ratio, finely granular “salt and pepper” chromatin and nuclear grooves. Pseudopapillary structures with arborizing capillaries and metachromic core on Diff-Quik-stained smears were lined by epithelioid cells. Acinar and rosette-like formations, as well as single neoplastic cells were observed [Figure 1]. The background was clean, but scattered foamy histiocytes were present. Many tumor cells exhibited single or multiple clear cytoplasmic vacuoles, displacing the nucleus [Figures 2 and 3]. The vacuoles were well-defined and variable in size, producing coin-shaped empty spaces in the cytoplasm [Figures 4 and 5]. Necrosis and mitosis were not seen. Coin-shaped vacuoles were mimicking signet-ring appearance on the cell-block [Figures 6 and 7]. Periodic acid-schiff (PAS) and mucicarmine stains were negative on the cell block sections.

Bottom Line: Acinar and rosette-like formations, as well as single neoplastic cells were also observed.An unusual cytologic feature was the presence of large, clear cytoplasmic vacuoles.The diagnosis of SPN was confirmed by characteristic immunocytochemical staining pattern including nuclear staining for β-catenin, cytoplasmic staining for vimentin and lack of reactivity for cytokeratin.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology-Cytology, Istanbul University, CERRAHPASA Medical School, Istanbul, Turkey.

ABSTRACT
Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor of uncertain malignant potential, predominantly affecting young adult females. We report a case of clear cell variant of SPN, which was diagnosed by fine needle aspiration biopsy. The aspirate was highly cellular and exhibited delicate branching papillary structures with central capillaries covered with several layers of plasmacytoid tumor cells. Acinar and rosette-like formations, as well as single neoplastic cells were also observed. An unusual cytologic feature was the presence of large, clear cytoplasmic vacuoles. The diagnosis of SPN was confirmed by characteristic immunocytochemical staining pattern including nuclear staining for β-catenin, cytoplasmic staining for vimentin and lack of reactivity for cytokeratin.

No MeSH data available.


Related in: MedlinePlus