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The factors affecting effectiveness of treatment in phages therapy.

Ly-Chatain MH - Front Microbiol (2014)

Bottom Line: The use of bacteriophages has numerous advantages over traditional antimicrobials.The effectiveness of phage applications in fighting against pathogenic bacteria depends on several factors such as the bacteriophages/target bacteria ratio, the mode and moment of treatment, environmental conditions (pH, temperature...), the neutralization of phage and accessibility to target bacteria, amongst others.This report presents these factors and the challenges involved in developing phage therapy applications.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire Bioengénierie et Dynamiques Microbiennes aux Interfaces Alimentaires (BioDymia) ISARA-Lyon Lyon, France.

ABSTRACT
In recent years, the use of lytic bacteriophages as antimicrobial agents controlling pathogenic bacteria has appeared as a promising new alternative strategy in the face of growing antibiotic resistance which has caused problems in many fields including medicine, veterinary medicine, and aquaculture. The use of bacteriophages has numerous advantages over traditional antimicrobials. The effectiveness of phage applications in fighting against pathogenic bacteria depends on several factors such as the bacteriophages/target bacteria ratio, the mode and moment of treatment, environmental conditions (pH, temperature...), the neutralization of phage and accessibility to target bacteria, amongst others. This report presents these factors and the challenges involved in developing phage therapy applications.

No MeSH data available.


Related in: MedlinePlus

Factors affecting the effectiveness of phage use against pathogenic bacteria.
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Figure 1: Factors affecting the effectiveness of phage use against pathogenic bacteria.

Mentions: Despite this increase in research interest and the production of phage products, the application in phage therapy was not always successful. The effectiveness of phage applications against pathogenic bacteria depends on several factors such as the bacteriophage/bacteria ratio, physico-chemical factors (pH, temperature...), phage neutralization or resistance to phage. Moreover, the data in vitro cannot be directly applied to the in vivo situation and nor can in vivo data for one phage be transferred to another phage. Critical parameters that affect phage therapy are the phage adsorption rate, burst size, the latent period and initial phage dose (Payne et al., 2000; Payne and Jansen, 2001). Another critical parameter is the clearance rate of the phage particles from the body fluids by the reticuloendothelial system or the phage-neutralizing antibody phenomena. Some key factors are presented in Figure 1.


The factors affecting effectiveness of treatment in phages therapy.

Ly-Chatain MH - Front Microbiol (2014)

Factors affecting the effectiveness of phage use against pathogenic bacteria.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927074&req=5

Figure 1: Factors affecting the effectiveness of phage use against pathogenic bacteria.
Mentions: Despite this increase in research interest and the production of phage products, the application in phage therapy was not always successful. The effectiveness of phage applications against pathogenic bacteria depends on several factors such as the bacteriophage/bacteria ratio, physico-chemical factors (pH, temperature...), phage neutralization or resistance to phage. Moreover, the data in vitro cannot be directly applied to the in vivo situation and nor can in vivo data for one phage be transferred to another phage. Critical parameters that affect phage therapy are the phage adsorption rate, burst size, the latent period and initial phage dose (Payne et al., 2000; Payne and Jansen, 2001). Another critical parameter is the clearance rate of the phage particles from the body fluids by the reticuloendothelial system or the phage-neutralizing antibody phenomena. Some key factors are presented in Figure 1.

Bottom Line: The use of bacteriophages has numerous advantages over traditional antimicrobials.The effectiveness of phage applications in fighting against pathogenic bacteria depends on several factors such as the bacteriophages/target bacteria ratio, the mode and moment of treatment, environmental conditions (pH, temperature...), the neutralization of phage and accessibility to target bacteria, amongst others.This report presents these factors and the challenges involved in developing phage therapy applications.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire Bioengénierie et Dynamiques Microbiennes aux Interfaces Alimentaires (BioDymia) ISARA-Lyon Lyon, France.

ABSTRACT
In recent years, the use of lytic bacteriophages as antimicrobial agents controlling pathogenic bacteria has appeared as a promising new alternative strategy in the face of growing antibiotic resistance which has caused problems in many fields including medicine, veterinary medicine, and aquaculture. The use of bacteriophages has numerous advantages over traditional antimicrobials. The effectiveness of phage applications in fighting against pathogenic bacteria depends on several factors such as the bacteriophages/target bacteria ratio, the mode and moment of treatment, environmental conditions (pH, temperature...), the neutralization of phage and accessibility to target bacteria, amongst others. This report presents these factors and the challenges involved in developing phage therapy applications.

No MeSH data available.


Related in: MedlinePlus