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Dapsone in dermatology and beyond.

Wozel G, Blasum C - Arch. Dermatol. Res. (2013)

Bottom Line: Thus, dapsone clearly has dual functions of both: antimicrobial/antiprotozoal effects and anti-inflammatory features similarly to non-steroidal anti-inflammatory drugs.Moreover, attention has been paid to mechanisms by which dapsone mediates effects in more complex settings like impact of lifespan, stroke, glioblastoma, or as anticonvulsive agent.The steroid-sparing effect of dapsone is useful for numerous clinical entities.

View Article: PubMed Central - PubMed

Affiliation: Study Centre for Clinical Trials, Dermatology, Gesellschaft für Wissens- und Technologietransfer der Technischen Universität Dresden mbH, Blasewitzer Str. 43, 01307, Dresden, Germany, Gkatharina.bluemlein@uniklinikum-dresden.de.

ABSTRACT
Dapsone (4,4'-diaminodiphenylsulfone) is an aniline derivative belonging to the group of synthetic sulfones. In 1937 against the background of sulfonamide era the microbial activity of dapsone has been discovered. Shortly thereafter, the use of dapsone to treat non-pathogen-caused diseases revealed alternate antiinflammatory mechanisms that initially were elucidated by inflammatory animal models. Thus, dapsone clearly has dual functions of both: antimicrobial/antiprotozoal effects and anti-inflammatory features similarly to non-steroidal anti-inflammatory drugs. The latter capabilities primarily were used in treating chronic inflammatory disorders. Dapsone has been investigated predominantly by in vitro methods aiming to get more insights into the effect of dapsone to inflammatory effector cells, cytokines, and/or mediators, such as cellular toxic oxygen metabolism, myoloperoxidase-/halogenid system, adhesion molecules, chemotaxis, membrane-associated phospholipids, prostaglandins, leukotrienes, interleukin-8, tumor necrosis factor α, lymphocyte functions, and tumor growth. Moreover, attention has been paid to mechanisms by which dapsone mediates effects in more complex settings like impact of lifespan, stroke, glioblastoma, or as anticonvulsive agent. Additionally, there are some dermatological investigations in human being using dapsone and its metabolites (e.g., leukotriene B4-induced chemotaxis, ultraviolet-induced erythema). It could be established that dapsone metabolites by their own have anti-inflammatory properties. Pharmacology and mechanisms of action are determining factors for clinical use of dapsone chiefly in neutrophilic and/or eosinophilic dermatoses and in chronic disorders outside the field of dermatology. The steroid-sparing effect of dapsone is useful for numerous clinical entities. Future avenues of investigations will provide more information on this fascinating and essential agent.

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Related in: MedlinePlus

Survival curves of Ceanorhabditis elegans (n = 129) treated with dapsone (2 mmol) during their entire life time compared with worms that were untreated. (according to Cho et al. [26])
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Fig6: Survival curves of Ceanorhabditis elegans (n = 129) treated with dapsone (2 mmol) during their entire life time compared with worms that were untreated. (according to Cho et al. [26])

Mentions: In the light of observations that—despite their disease-induced socioeconomic drawbacks—life expectancy of leprosy patients under dapsone therapy is increased, South Korean authors investigated the effect of dapsone on the lifespan in multicellular organism [26]. In their anti-aging-model, dapsone in concentrations equalling that achieved under therapy induced a marked elongation of the median lifespan of Caenorhabditis elegans (Fig. 6). The nematode worm is a small, relatively simple, and precisely structured organism. C. elegans is one of the most powerful animal models currently in use for studying the aging process and lifespan.Fig. 6


Dapsone in dermatology and beyond.

Wozel G, Blasum C - Arch. Dermatol. Res. (2013)

Survival curves of Ceanorhabditis elegans (n = 129) treated with dapsone (2 mmol) during their entire life time compared with worms that were untreated. (according to Cho et al. [26])
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3927068&req=5

Fig6: Survival curves of Ceanorhabditis elegans (n = 129) treated with dapsone (2 mmol) during their entire life time compared with worms that were untreated. (according to Cho et al. [26])
Mentions: In the light of observations that—despite their disease-induced socioeconomic drawbacks—life expectancy of leprosy patients under dapsone therapy is increased, South Korean authors investigated the effect of dapsone on the lifespan in multicellular organism [26]. In their anti-aging-model, dapsone in concentrations equalling that achieved under therapy induced a marked elongation of the median lifespan of Caenorhabditis elegans (Fig. 6). The nematode worm is a small, relatively simple, and precisely structured organism. C. elegans is one of the most powerful animal models currently in use for studying the aging process and lifespan.Fig. 6

Bottom Line: Thus, dapsone clearly has dual functions of both: antimicrobial/antiprotozoal effects and anti-inflammatory features similarly to non-steroidal anti-inflammatory drugs.Moreover, attention has been paid to mechanisms by which dapsone mediates effects in more complex settings like impact of lifespan, stroke, glioblastoma, or as anticonvulsive agent.The steroid-sparing effect of dapsone is useful for numerous clinical entities.

View Article: PubMed Central - PubMed

Affiliation: Study Centre for Clinical Trials, Dermatology, Gesellschaft für Wissens- und Technologietransfer der Technischen Universität Dresden mbH, Blasewitzer Str. 43, 01307, Dresden, Germany, Gkatharina.bluemlein@uniklinikum-dresden.de.

ABSTRACT
Dapsone (4,4'-diaminodiphenylsulfone) is an aniline derivative belonging to the group of synthetic sulfones. In 1937 against the background of sulfonamide era the microbial activity of dapsone has been discovered. Shortly thereafter, the use of dapsone to treat non-pathogen-caused diseases revealed alternate antiinflammatory mechanisms that initially were elucidated by inflammatory animal models. Thus, dapsone clearly has dual functions of both: antimicrobial/antiprotozoal effects and anti-inflammatory features similarly to non-steroidal anti-inflammatory drugs. The latter capabilities primarily were used in treating chronic inflammatory disorders. Dapsone has been investigated predominantly by in vitro methods aiming to get more insights into the effect of dapsone to inflammatory effector cells, cytokines, and/or mediators, such as cellular toxic oxygen metabolism, myoloperoxidase-/halogenid system, adhesion molecules, chemotaxis, membrane-associated phospholipids, prostaglandins, leukotrienes, interleukin-8, tumor necrosis factor α, lymphocyte functions, and tumor growth. Moreover, attention has been paid to mechanisms by which dapsone mediates effects in more complex settings like impact of lifespan, stroke, glioblastoma, or as anticonvulsive agent. Additionally, there are some dermatological investigations in human being using dapsone and its metabolites (e.g., leukotriene B4-induced chemotaxis, ultraviolet-induced erythema). It could be established that dapsone metabolites by their own have anti-inflammatory properties. Pharmacology and mechanisms of action are determining factors for clinical use of dapsone chiefly in neutrophilic and/or eosinophilic dermatoses and in chronic disorders outside the field of dermatology. The steroid-sparing effect of dapsone is useful for numerous clinical entities. Future avenues of investigations will provide more information on this fascinating and essential agent.

Show MeSH
Related in: MedlinePlus