Limits...
Low-grade myxofibrosarcoma following a metal implantation in femur: a case report.

Li W, Li D, Zhu X, Lu S, He C, Yang Q - Diagn Pathol (2014)

Bottom Line: Immunohistochemical studies revealed that the tumor cells was positive for VIM and MDM2, and was negative for CK, MSA, SMA, DES, S-100 and CD34.Labeling index of Ki-67 was 25%.The clinical and imaging examinations did not reveal the evidence of a primary cancer elsewhere, and the patient had no personal or family history of malignancy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Gannan Medical University, No, 1, Yixueyuan Road, Ganzhou, Jiangxi 341000, China. dan.li.liu@hotmail.com.

ABSTRACT

Unlabelled: Myxofibrosarcoma is a myxoid variant of malignant fibrous histiocytoma that most commonly involves the extremities of elderly people. However, a primary myxofibrosarcoma with bone invasion in young adults is extremely rare. Herein, we report the case of a 31-year-old male with a gradually enlarging left thigh mass, who had a history of left femur fracture and received an open reduction and internal fixation with titanium alloy plates and screws 33 months previously. Imaging investigations revealed an irregularly shaped soft tissue mass around the left femur shaft and a partial bone defect in the middle one-third of the left femur. Pathological examination of the resected specimen showed a multi-nodular appearance, abundant myxoid matrix and elongated curvilinear capillaries. Immunohistochemical studies revealed that the tumor cells was positive for VIM and MDM2, and was negative for CK, MSA, SMA, DES, S-100 and CD34. Labeling index of Ki-67 was 25%. Based on the morphological finding and immunostaining, it was diagnosed as a low-grade myxofibrosarcoma. The clinical and imaging examinations did not reveal the evidence of a primary cancer elsewhere, and the patient had no personal or family history of malignancy. To our knowledge, this is the first case of a primary myxofibrosarcoma developed following a fracture and metal implantation in young adults.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1745984882113605.

Show MeSH

Related in: MedlinePlus

Histopathological examination of the tumor. (a) Magnification, ×40. (b) Magnification, ×100. H&E staining showed that the tumor was predominantly composed of a large number of diffuse fusiform cells and myxoid matrix. The fusiform tumor cells were arranged in a multi-nodular pattern, with indistinct cell margins, slightly eosinophilic cytoplasm, and hyperchromatic atypical nuclei. Mitoses were infrequent. Many elongated curvilinear capillaries were observed.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC3926977&req=5

Figure 2: Histopathological examination of the tumor. (a) Magnification, ×40. (b) Magnification, ×100. H&E staining showed that the tumor was predominantly composed of a large number of diffuse fusiform cells and myxoid matrix. The fusiform tumor cells were arranged in a multi-nodular pattern, with indistinct cell margins, slightly eosinophilic cytoplasm, and hyperchromatic atypical nuclei. Mitoses were infrequent. Many elongated curvilinear capillaries were observed.

Mentions: Tissue biopsy was performed, and histopathological examination reported that the tumor was predominantly composed of a large number of diffuse fusiform cells and myxoid matrix. The fusiform tumor cells were arranged in a multi-nodular pattern, with indistinct cell margins, slightly eosinophilic cytoplasm, and hyperchromatic atypical nuclei. Mitoses were infrequent. In addition, many elongated curvilinear capillaries were observed (Figure 2). These cytological findings suggested a malignant tumor of mesenchymal origin.


Low-grade myxofibrosarcoma following a metal implantation in femur: a case report.

Li W, Li D, Zhu X, Lu S, He C, Yang Q - Diagn Pathol (2014)

Histopathological examination of the tumor. (a) Magnification, ×40. (b) Magnification, ×100. H&E staining showed that the tumor was predominantly composed of a large number of diffuse fusiform cells and myxoid matrix. The fusiform tumor cells were arranged in a multi-nodular pattern, with indistinct cell margins, slightly eosinophilic cytoplasm, and hyperchromatic atypical nuclei. Mitoses were infrequent. Many elongated curvilinear capillaries were observed.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3926977&req=5

Figure 2: Histopathological examination of the tumor. (a) Magnification, ×40. (b) Magnification, ×100. H&E staining showed that the tumor was predominantly composed of a large number of diffuse fusiform cells and myxoid matrix. The fusiform tumor cells were arranged in a multi-nodular pattern, with indistinct cell margins, slightly eosinophilic cytoplasm, and hyperchromatic atypical nuclei. Mitoses were infrequent. Many elongated curvilinear capillaries were observed.
Mentions: Tissue biopsy was performed, and histopathological examination reported that the tumor was predominantly composed of a large number of diffuse fusiform cells and myxoid matrix. The fusiform tumor cells were arranged in a multi-nodular pattern, with indistinct cell margins, slightly eosinophilic cytoplasm, and hyperchromatic atypical nuclei. Mitoses were infrequent. In addition, many elongated curvilinear capillaries were observed (Figure 2). These cytological findings suggested a malignant tumor of mesenchymal origin.

Bottom Line: Immunohistochemical studies revealed that the tumor cells was positive for VIM and MDM2, and was negative for CK, MSA, SMA, DES, S-100 and CD34.Labeling index of Ki-67 was 25%.The clinical and imaging examinations did not reveal the evidence of a primary cancer elsewhere, and the patient had no personal or family history of malignancy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Gannan Medical University, No, 1, Yixueyuan Road, Ganzhou, Jiangxi 341000, China. dan.li.liu@hotmail.com.

ABSTRACT

Unlabelled: Myxofibrosarcoma is a myxoid variant of malignant fibrous histiocytoma that most commonly involves the extremities of elderly people. However, a primary myxofibrosarcoma with bone invasion in young adults is extremely rare. Herein, we report the case of a 31-year-old male with a gradually enlarging left thigh mass, who had a history of left femur fracture and received an open reduction and internal fixation with titanium alloy plates and screws 33 months previously. Imaging investigations revealed an irregularly shaped soft tissue mass around the left femur shaft and a partial bone defect in the middle one-third of the left femur. Pathological examination of the resected specimen showed a multi-nodular appearance, abundant myxoid matrix and elongated curvilinear capillaries. Immunohistochemical studies revealed that the tumor cells was positive for VIM and MDM2, and was negative for CK, MSA, SMA, DES, S-100 and CD34. Labeling index of Ki-67 was 25%. Based on the morphological finding and immunostaining, it was diagnosed as a low-grade myxofibrosarcoma. The clinical and imaging examinations did not reveal the evidence of a primary cancer elsewhere, and the patient had no personal or family history of malignancy. To our knowledge, this is the first case of a primary myxofibrosarcoma developed following a fracture and metal implantation in young adults.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1745984882113605.

Show MeSH
Related in: MedlinePlus