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Protecting the proteome: Eukaryotic cotranslational quality control pathways.

Lykke-Andersen J, Bennett EJ - J. Cell Biol. (2014)

Bottom Line: The correct decoding of messenger RNAs (mRNAs) into proteins is an essential cellular task.The translational process is monitored by several quality control (QC) mechanisms that recognize defective translation complexes in which ribosomes are stalled on substrate mRNAs.These QC events promote the disassembly of the stalled translation complex and the recycling and/or degradation of the individual mRNA, ribosomal, and/or nascent polypeptide components, thereby clearing the cell of improper translation products and defective components of the translation machinery.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.

ABSTRACT
The correct decoding of messenger RNAs (mRNAs) into proteins is an essential cellular task. The translational process is monitored by several quality control (QC) mechanisms that recognize defective translation complexes in which ribosomes are stalled on substrate mRNAs. Stalled translation complexes occur when defects in the mRNA template, the translation machinery, or the nascent polypeptide arrest the ribosome during translation elongation or termination. These QC events promote the disassembly of the stalled translation complex and the recycling and/or degradation of the individual mRNA, ribosomal, and/or nascent polypeptide components, thereby clearing the cell of improper translation products and defective components of the translation machinery.

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Multiple cotranslational quality control (QC) pathways monitor the translation process. QC pathways cotranslationally detect and degrade defective nascent polypeptides, ribosomes, and mRNAs.
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fig1: Multiple cotranslational quality control (QC) pathways monitor the translation process. QC pathways cotranslationally detect and degrade defective nascent polypeptides, ribosomes, and mRNAs.

Mentions: The correct translation of messenger RNAs (mRNAs) into functional proteins requires the precise coordination of staggeringly complex molecular factors that govern protein biogenesis. Defects in protein synthesis can lead to the production of potentially toxic defective translation products whose unregulated accumulation can negatively impact nearly every cellular pathway. In addition, RNAs and proteins involved in translation are subject to damage by irradiation and chemical modification that can negatively impact protein biogenesis. An important set of quality control (QC) pathways specializes in cotranslationally monitoring protein synthesis to prevent deleterious production of erroneous translation products (Fig. 1). Translational stalling provides an opportunity for the QC machinery to engage the translational machinery and subvert the normal translational process. Once recruited to stalled translation complexes, the QC pathways disassemble the defective translation complex and recycle and/or degrade its individual components. A subset of these pathways acts to degrade defective nascent polypeptides that fail to undergo proper cotranslational folding. Another subset resolves stalls in translation elongation or termination that arise from defects in the mRNA template, translation machinery, or nascent polypeptide. Collectively, these cotranslational QC pathways protect the proteome by clearing defective mRNAs, ribosomes, and polypeptides.


Protecting the proteome: Eukaryotic cotranslational quality control pathways.

Lykke-Andersen J, Bennett EJ - J. Cell Biol. (2014)

Multiple cotranslational quality control (QC) pathways monitor the translation process. QC pathways cotranslationally detect and degrade defective nascent polypeptides, ribosomes, and mRNAs.
© Copyright Policy - openaccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3926952&req=5

fig1: Multiple cotranslational quality control (QC) pathways monitor the translation process. QC pathways cotranslationally detect and degrade defective nascent polypeptides, ribosomes, and mRNAs.
Mentions: The correct translation of messenger RNAs (mRNAs) into functional proteins requires the precise coordination of staggeringly complex molecular factors that govern protein biogenesis. Defects in protein synthesis can lead to the production of potentially toxic defective translation products whose unregulated accumulation can negatively impact nearly every cellular pathway. In addition, RNAs and proteins involved in translation are subject to damage by irradiation and chemical modification that can negatively impact protein biogenesis. An important set of quality control (QC) pathways specializes in cotranslationally monitoring protein synthesis to prevent deleterious production of erroneous translation products (Fig. 1). Translational stalling provides an opportunity for the QC machinery to engage the translational machinery and subvert the normal translational process. Once recruited to stalled translation complexes, the QC pathways disassemble the defective translation complex and recycle and/or degrade its individual components. A subset of these pathways acts to degrade defective nascent polypeptides that fail to undergo proper cotranslational folding. Another subset resolves stalls in translation elongation or termination that arise from defects in the mRNA template, translation machinery, or nascent polypeptide. Collectively, these cotranslational QC pathways protect the proteome by clearing defective mRNAs, ribosomes, and polypeptides.

Bottom Line: The correct decoding of messenger RNAs (mRNAs) into proteins is an essential cellular task.The translational process is monitored by several quality control (QC) mechanisms that recognize defective translation complexes in which ribosomes are stalled on substrate mRNAs.These QC events promote the disassembly of the stalled translation complex and the recycling and/or degradation of the individual mRNA, ribosomal, and/or nascent polypeptide components, thereby clearing the cell of improper translation products and defective components of the translation machinery.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.

ABSTRACT
The correct decoding of messenger RNAs (mRNAs) into proteins is an essential cellular task. The translational process is monitored by several quality control (QC) mechanisms that recognize defective translation complexes in which ribosomes are stalled on substrate mRNAs. Stalled translation complexes occur when defects in the mRNA template, the translation machinery, or the nascent polypeptide arrest the ribosome during translation elongation or termination. These QC events promote the disassembly of the stalled translation complex and the recycling and/or degradation of the individual mRNA, ribosomal, and/or nascent polypeptide components, thereby clearing the cell of improper translation products and defective components of the translation machinery.

Show MeSH
Related in: MedlinePlus