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Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats.

Adaramoye OA, Akanni OO - Adv Pharmacol Sci (2014)

Bottom Line: Treatment with AA significantly reduced the relative weight of the organs and lipid parameters.In HC rats, serum LDH, ALT, and AST activities and levels of LPO were increased, whereas hepatic and cardiac SOD, CAT, and GPx were reduced.Extract of AA had protective effects against dietary cholesterol-induced hypercholesterolemia.

View Article: PubMed Central - PubMed

Affiliation: Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan 20005, Nigeria.

ABSTRACT
We investigated the effects of methanol extract of Artocarpus altilis (AA) on atherogenic indices and redox status of cellular system of rats fed with dietary cholesterol while Questran (QUE) served as standard. Biochemical indices such as total cholesterol (TC), triglycerides (TG), low- and high-density lipoproteins-cholesterol (LDL-C and HDL-C), aspartate and alanine aminotransferases (AST and ALT), lactate dehydrogenase (LDH), reduced glutathione, glutathione-s-transferase, glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and lipid peroxidation (LPO) were assessed. Hypercholesterolemic (HC) rats had significantly increased relative weight of liver and heart. Dietary cholesterol caused a significant increase (P < 0.05) in the levels of serum, hepatic, and cardiac TC by 110%, 70%, and 85%, LDL-C by 79%, 82%, and 176%, and TG by 68%, 96%, and 62%, respectively. Treatment with AA significantly reduced the relative weight of the organs and lipid parameters. There were beneficial increases in serum and cardiac HDL-C levels in HC rats treated with AA. In HC rats, serum LDH, ALT, and AST activities and levels of LPO were increased, whereas hepatic and cardiac SOD, CAT, and GPx were reduced. All biochemical and histological alterations were ameliorated upon treatment with AA. Extract of AA had protective effects against dietary cholesterol-induced hypercholesterolemia.

No MeSH data available.


Related in: MedlinePlus

Effects of methanol extract of Artocarpus altilis and Questran on cardiac total cholesterol and triglyceride levels of hypercholesterolemic rats. *Significantly different from control (P < 0.05), **significantly different from HC (P < 0.05). HC: Hypercholesterolemic rats, AA1: Artocarpus altilis at 100 mg/kg, AA2: Artocarpus altilis at 200 mg/kg, and QUE: Questran at 0.26 g/kg.
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fig1: Effects of methanol extract of Artocarpus altilis and Questran on cardiac total cholesterol and triglyceride levels of hypercholesterolemic rats. *Significantly different from control (P < 0.05), **significantly different from HC (P < 0.05). HC: Hypercholesterolemic rats, AA1: Artocarpus altilis at 100 mg/kg, AA2: Artocarpus altilis at 200 mg/kg, and QUE: Questran at 0.26 g/kg.

Mentions: Feeding rats on high dietary cholesterol for nine consecutive weeks significantly (P < 0.05) increased the serum, hepatic, and cardiac total cholesterol levels by 110%, 70%, and 85%, respectively (Table 6 and Figures 1 and 2). Furthermore, serum, hepatic, and cardiac triglycerides increased by 68%, 96%, and 62%, while serum LDL-C increased by 79%, respectively, in HC rats relative to controls. In addition, HC rats had significantly lower HDL-C values when compared to the control (Table 6). Administration of AA at 200 mg/kg attenuated the elevated levels of these lipid indices to near normal in the tissues of HC rats. The protective effect of AA at 200 mg/kg seems better than the standard hypolipidemic drug (Questran). Furthermore, AA increased serum antiatherogenic index in HC rats, while coronary risk index was decreased (Table 7).


Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats.

Adaramoye OA, Akanni OO - Adv Pharmacol Sci (2014)

Effects of methanol extract of Artocarpus altilis and Questran on cardiac total cholesterol and triglyceride levels of hypercholesterolemic rats. *Significantly different from control (P < 0.05), **significantly different from HC (P < 0.05). HC: Hypercholesterolemic rats, AA1: Artocarpus altilis at 100 mg/kg, AA2: Artocarpus altilis at 200 mg/kg, and QUE: Questran at 0.26 g/kg.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3926424&req=5

fig1: Effects of methanol extract of Artocarpus altilis and Questran on cardiac total cholesterol and triglyceride levels of hypercholesterolemic rats. *Significantly different from control (P < 0.05), **significantly different from HC (P < 0.05). HC: Hypercholesterolemic rats, AA1: Artocarpus altilis at 100 mg/kg, AA2: Artocarpus altilis at 200 mg/kg, and QUE: Questran at 0.26 g/kg.
Mentions: Feeding rats on high dietary cholesterol for nine consecutive weeks significantly (P < 0.05) increased the serum, hepatic, and cardiac total cholesterol levels by 110%, 70%, and 85%, respectively (Table 6 and Figures 1 and 2). Furthermore, serum, hepatic, and cardiac triglycerides increased by 68%, 96%, and 62%, while serum LDL-C increased by 79%, respectively, in HC rats relative to controls. In addition, HC rats had significantly lower HDL-C values when compared to the control (Table 6). Administration of AA at 200 mg/kg attenuated the elevated levels of these lipid indices to near normal in the tissues of HC rats. The protective effect of AA at 200 mg/kg seems better than the standard hypolipidemic drug (Questran). Furthermore, AA increased serum antiatherogenic index in HC rats, while coronary risk index was decreased (Table 7).

Bottom Line: Treatment with AA significantly reduced the relative weight of the organs and lipid parameters.In HC rats, serum LDH, ALT, and AST activities and levels of LPO were increased, whereas hepatic and cardiac SOD, CAT, and GPx were reduced.Extract of AA had protective effects against dietary cholesterol-induced hypercholesterolemia.

View Article: PubMed Central - PubMed

Affiliation: Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan 20005, Nigeria.

ABSTRACT
We investigated the effects of methanol extract of Artocarpus altilis (AA) on atherogenic indices and redox status of cellular system of rats fed with dietary cholesterol while Questran (QUE) served as standard. Biochemical indices such as total cholesterol (TC), triglycerides (TG), low- and high-density lipoproteins-cholesterol (LDL-C and HDL-C), aspartate and alanine aminotransferases (AST and ALT), lactate dehydrogenase (LDH), reduced glutathione, glutathione-s-transferase, glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and lipid peroxidation (LPO) were assessed. Hypercholesterolemic (HC) rats had significantly increased relative weight of liver and heart. Dietary cholesterol caused a significant increase (P < 0.05) in the levels of serum, hepatic, and cardiac TC by 110%, 70%, and 85%, LDL-C by 79%, 82%, and 176%, and TG by 68%, 96%, and 62%, respectively. Treatment with AA significantly reduced the relative weight of the organs and lipid parameters. There were beneficial increases in serum and cardiac HDL-C levels in HC rats treated with AA. In HC rats, serum LDH, ALT, and AST activities and levels of LPO were increased, whereas hepatic and cardiac SOD, CAT, and GPx were reduced. All biochemical and histological alterations were ameliorated upon treatment with AA. Extract of AA had protective effects against dietary cholesterol-induced hypercholesterolemia.

No MeSH data available.


Related in: MedlinePlus