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Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-induced inflammatory bowel disorder in albino rats.

Kondamudi PK, Kovelamudi H, Mathew G, Nayak PG, Rao MC, Shenoy RR - ScientificWorldJournal (2014)

Bottom Line: The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups.Serum nitrite levels were found to be insignificant between the different groups.The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.

ABSTRACT

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats.

Methods: The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed.

Results: The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups.

Conclusions: The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

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Related in: MedlinePlus

Histopathological studies; (a) normal control; (b) AA group; (c) SES treated; and (d) SS treated.
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fig7: Histopathological studies; (a) normal control; (b) AA group; (c) SES treated; and (d) SS treated.

Mentions: The normal histology of the colon was noted in the control (Figure 7(a)). In the AA treated group, colonic shrinkage of villi and mucosal layer was clearly seen (Figure 7(b)). Sesamol and sulfasalazine treated groups were similar to control (Figures 7(c) and 7(d), resp.) depicting normal crypts and few inflammatory cell infiltration.


Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-induced inflammatory bowel disorder in albino rats.

Kondamudi PK, Kovelamudi H, Mathew G, Nayak PG, Rao MC, Shenoy RR - ScientificWorldJournal (2014)

Histopathological studies; (a) normal control; (b) AA group; (c) SES treated; and (d) SS treated.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3926374&req=5

fig7: Histopathological studies; (a) normal control; (b) AA group; (c) SES treated; and (d) SS treated.
Mentions: The normal histology of the colon was noted in the control (Figure 7(a)). In the AA treated group, colonic shrinkage of villi and mucosal layer was clearly seen (Figure 7(b)). Sesamol and sulfasalazine treated groups were similar to control (Figures 7(c) and 7(d), resp.) depicting normal crypts and few inflammatory cell infiltration.

Bottom Line: The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups.Serum nitrite levels were found to be insignificant between the different groups.The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.

ABSTRACT

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats.

Methods: The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed.

Results: The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups.

Conclusions: The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

Show MeSH
Related in: MedlinePlus