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Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-induced inflammatory bowel disorder in albino rats.

Kondamudi PK, Kovelamudi H, Mathew G, Nayak PG, Rao MC, Shenoy RR - ScientificWorldJournal (2014)

Bottom Line: The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups.Serum nitrite levels were found to be insignificant between the different groups.The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.

ABSTRACT

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats.

Methods: The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed.

Results: The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups.

Conclusions: The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

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Related in: MedlinePlus

Effect of sesamol and sulfasalazine on the levels of MPO in tissue homogenates. aP < 0.05 as compared to positive control; bP < 0.05 as compared to AA group only.
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fig3: Effect of sesamol and sulfasalazine on the levels of MPO in tissue homogenates. aP < 0.05 as compared to positive control; bP < 0.05 as compared to AA group only.

Mentions: Figure 3 depicts a significant rise in the levels of MPO at P < 0.05 in the AA group which was found to be 193.71 ± 21.86 μg/mg of tissue. There was a significant decrease in the levels of MPO in drug treated groups (SES and SS) when compared to AA group at P < 0.05, which was found to be 68.95 ± 23.16 and 25.83 ± 3.33 μg/mg of tissue, respectively. In between the standard and test drug treatment groups, no significant difference was observed.


Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-induced inflammatory bowel disorder in albino rats.

Kondamudi PK, Kovelamudi H, Mathew G, Nayak PG, Rao MC, Shenoy RR - ScientificWorldJournal (2014)

Effect of sesamol and sulfasalazine on the levels of MPO in tissue homogenates. aP < 0.05 as compared to positive control; bP < 0.05 as compared to AA group only.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3926374&req=5

fig3: Effect of sesamol and sulfasalazine on the levels of MPO in tissue homogenates. aP < 0.05 as compared to positive control; bP < 0.05 as compared to AA group only.
Mentions: Figure 3 depicts a significant rise in the levels of MPO at P < 0.05 in the AA group which was found to be 193.71 ± 21.86 μg/mg of tissue. There was a significant decrease in the levels of MPO in drug treated groups (SES and SS) when compared to AA group at P < 0.05, which was found to be 68.95 ± 23.16 and 25.83 ± 3.33 μg/mg of tissue, respectively. In between the standard and test drug treatment groups, no significant difference was observed.

Bottom Line: The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups.Serum nitrite levels were found to be insignificant between the different groups.The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.

ABSTRACT

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats.

Methods: The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed.

Results: The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups.

Conclusions: The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

Show MeSH
Related in: MedlinePlus