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Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-induced inflammatory bowel disorder in albino rats.

Kondamudi PK, Kovelamudi H, Mathew G, Nayak PG, Rao MC, Shenoy RR - ScientificWorldJournal (2014)

Bottom Line: The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups.Serum nitrite levels were found to be insignificant between the different groups.The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.

ABSTRACT

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats.

Methods: The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed.

Results: The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups.

Conclusions: The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

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Related in: MedlinePlus

Effects of sesamol and sulfasalazine on the body weight of albino rats. aP < 0.05 as compared to positive control.
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Related In: Results  -  Collection


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fig1: Effects of sesamol and sulfasalazine on the body weight of albino rats. aP < 0.05 as compared to positive control.

Mentions: Figure 1 shows that the intracolonical administration of acetic acid caused the body weight to decrease from the 4th day onwards and continued until the 7th day, that is, the day of sacrifice. Compared to control there was a significant weight loss in AA and SES groups which were found to be 188.0 ± 5.0, 181.6 ± 7.95, and 184.4 ± 2.4 g, respectively, at P < 0.05, whereas there was no significant weight loss in SS group which was found to be 169.5 ± 2.32. It was also found that there was a significant difference between the test drug (SES) and standard drug (SS) at P < 0.05.


Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-induced inflammatory bowel disorder in albino rats.

Kondamudi PK, Kovelamudi H, Mathew G, Nayak PG, Rao MC, Shenoy RR - ScientificWorldJournal (2014)

Effects of sesamol and sulfasalazine on the body weight of albino rats. aP < 0.05 as compared to positive control.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3926374&req=5

fig1: Effects of sesamol and sulfasalazine on the body weight of albino rats. aP < 0.05 as compared to positive control.
Mentions: Figure 1 shows that the intracolonical administration of acetic acid caused the body weight to decrease from the 4th day onwards and continued until the 7th day, that is, the day of sacrifice. Compared to control there was a significant weight loss in AA and SES groups which were found to be 188.0 ± 5.0, 181.6 ± 7.95, and 184.4 ± 2.4 g, respectively, at P < 0.05, whereas there was no significant weight loss in SS group which was found to be 169.5 ± 2.32. It was also found that there was a significant difference between the test drug (SES) and standard drug (SS) at P < 0.05.

Bottom Line: The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups.Serum nitrite levels were found to be insignificant between the different groups.The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.

ABSTRACT

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats.

Methods: The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed.

Results: The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups.

Conclusions: The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

Show MeSH
Related in: MedlinePlus