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Expression and prognostic significance of golgiglycoprotein73 (GP73) with epithelial-mesenchymal transition (EMT) related molecules in hepatocellular carcinoma (HCC).

Bao YX, Cao Q, Yang Y, Mao R, Xiao L, Zhang H, Zhao HR, Wen H - Diagn Pathol (2013)

Bottom Line: GP73 expression in HCC was higher compared with PCL tissues (χ2 = 73.60, P < 0.05).GP73 was negatively with E-cadherin and positively correlated with Vimentin.It might be associated with aggressive behavior of HCC and had influence on patients' OS.

View Article: PubMed Central - HTML - PubMed

Affiliation: Tumor Department, First Affiliated Hospital of Xinjiang Medical University (XJMU), Urumqi, China. wenhao@126.com.

ABSTRACT

Background: Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third cause of cancer-related deaths, worldwide. It is essential to develop an effective prognostic biomarker and determine the mechanisms underlying HCC invasion and metastasis.

Aims: This study aimed to investigate the expression of Golgi glycoprotein73 (GP73) and Epithelial-mesenchymal transition (EMT) molecules such as E-cadherin and Vimentin in HCC. We also evaluated the prognostic value of GP73 in HCC.

Methods: Immunohistochemistry (IHC) was used to determine the expression of GP73 and EMT molecules in 75 HCC specimens and the corresponding paracarcinomatous liver (PCL) tissues. Spearman's correlation test was used to analyze the correlation of GP73 and EMT molecules. Clinicopathological features of the HCC patients were also analyzed. Univariate survival analysis was performed by the Kaplan-Meier method and differences among the groups were analyzed by the Log-rank test.

Results: GP73 expression in HCC was higher compared with PCL tissues (χ2 = 73.60, P < 0.05). EMT molecules were also detected in HCC and PCL tissues. GP73 was negatively correlated with E-cadherin (r = - 0.49, P < 0.05), but positively correlated with Vimentin (r = 0.46, P < 0.05) in HCC. GP73 was correlated with the clinicopathological features including Edmondson grade, vascular invasion and TNM stage (P < 0.05), which was also associated with overall survival (OS) (P < 0.05).

Conclusions: GP73 was negatively with E-cadherin and positively correlated with Vimentin. It might be associated with aggressive behavior of HCC and had influence on patients' OS. Further research is needed to determine the potential of GP73.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/29 vs/1504046946108618; http://med.motic.com/MoticGallery/Slide?id=3b6a037e-f60e-4c68-9106-41e790de9431&user=2C69F0D6-A478-4A2B-ABF0-BB36763E8025; http://med.motic.com/MoticGallery/Slide?id=a25b5b32-b613-47b0-9f8b-e1e67a95d1bf&user=2C69F0D6-A478-4A2B-ABF0-BB36763E8025.

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Survival curves of HCC patients with different levels of GP73 expression. The surival curves showed that HCC patients with high levels of GP73 expression were different from patients with low levels.
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Figure 2: Survival curves of HCC patients with different levels of GP73 expression. The surival curves showed that HCC patients with high levels of GP73 expression were different from patients with low levels.

Mentions: We divided the 75 specimens into high and low levels. Kaplan–Meier survival analysis and Log-rank test showed that GP73 expression was significantly associated with the OS (Figure 2, Table 3). The median survival time of patients with high levels of GP73 was 7 months compared with 13 months associated with low GP73.


Expression and prognostic significance of golgiglycoprotein73 (GP73) with epithelial-mesenchymal transition (EMT) related molecules in hepatocellular carcinoma (HCC).

Bao YX, Cao Q, Yang Y, Mao R, Xiao L, Zhang H, Zhao HR, Wen H - Diagn Pathol (2013)

Survival curves of HCC patients with different levels of GP73 expression. The surival curves showed that HCC patients with high levels of GP73 expression were different from patients with low levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3924912&req=5

Figure 2: Survival curves of HCC patients with different levels of GP73 expression. The surival curves showed that HCC patients with high levels of GP73 expression were different from patients with low levels.
Mentions: We divided the 75 specimens into high and low levels. Kaplan–Meier survival analysis and Log-rank test showed that GP73 expression was significantly associated with the OS (Figure 2, Table 3). The median survival time of patients with high levels of GP73 was 7 months compared with 13 months associated with low GP73.

Bottom Line: GP73 expression in HCC was higher compared with PCL tissues (χ2 = 73.60, P < 0.05).GP73 was negatively with E-cadherin and positively correlated with Vimentin.It might be associated with aggressive behavior of HCC and had influence on patients' OS.

View Article: PubMed Central - HTML - PubMed

Affiliation: Tumor Department, First Affiliated Hospital of Xinjiang Medical University (XJMU), Urumqi, China. wenhao@126.com.

ABSTRACT

Background: Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third cause of cancer-related deaths, worldwide. It is essential to develop an effective prognostic biomarker and determine the mechanisms underlying HCC invasion and metastasis.

Aims: This study aimed to investigate the expression of Golgi glycoprotein73 (GP73) and Epithelial-mesenchymal transition (EMT) molecules such as E-cadherin and Vimentin in HCC. We also evaluated the prognostic value of GP73 in HCC.

Methods: Immunohistochemistry (IHC) was used to determine the expression of GP73 and EMT molecules in 75 HCC specimens and the corresponding paracarcinomatous liver (PCL) tissues. Spearman's correlation test was used to analyze the correlation of GP73 and EMT molecules. Clinicopathological features of the HCC patients were also analyzed. Univariate survival analysis was performed by the Kaplan-Meier method and differences among the groups were analyzed by the Log-rank test.

Results: GP73 expression in HCC was higher compared with PCL tissues (χ2 = 73.60, P < 0.05). EMT molecules were also detected in HCC and PCL tissues. GP73 was negatively correlated with E-cadherin (r = - 0.49, P < 0.05), but positively correlated with Vimentin (r = 0.46, P < 0.05) in HCC. GP73 was correlated with the clinicopathological features including Edmondson grade, vascular invasion and TNM stage (P < 0.05), which was also associated with overall survival (OS) (P < 0.05).

Conclusions: GP73 was negatively with E-cadherin and positively correlated with Vimentin. It might be associated with aggressive behavior of HCC and had influence on patients' OS. Further research is needed to determine the potential of GP73.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/29 vs/1504046946108618; http://med.motic.com/MoticGallery/Slide?id=3b6a037e-f60e-4c68-9106-41e790de9431&user=2C69F0D6-A478-4A2B-ABF0-BB36763E8025; http://med.motic.com/MoticGallery/Slide?id=a25b5b32-b613-47b0-9f8b-e1e67a95d1bf&user=2C69F0D6-A478-4A2B-ABF0-BB36763E8025.

Show MeSH
Related in: MedlinePlus