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Root maturation and dentin-pulp response to enamel matrix derivative in pulpotomized permanent teeth.

Darwish SS, Abd El Meguid SH, Wahba NA, Mohamed AA, Chrzanowski W, Abou Neel EA - J Tissue Eng (2014)

Bottom Line: The success of pulpotomy of young permanent teeth depends on the proper selection of dressing materials.The root apices of Emdogain-treated teeth became matured and closed by cementum that attached to new alveolar bone by a well-oriented periodontal ligament.In young permanent dentition, Emdogain could be a good candidate for periodontium but not dentino-pulpal complex regeneration.

View Article: PubMed Central - PubMed

Affiliation: Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Pharos University, Egypt.

ABSTRACT
The success of pulpotomy of young permanent teeth depends on the proper selection of dressing materials. This study aimed to evaluate the histological and histomorphometric response of dentin-pulp complex to the enamel matrix derivative (Emdogain(®) gel) compared to that of calcium hydroxide when used as a pulp dressing in immature young permanent dogs' teeth. Dentin-like tissues bridging the full width of the coronal pulp at the interface between the injured and healthy pulp tissues were seen after 1 month in both groups. With time, the dentin bridge increased in thickness for calcium hydroxide but disintegrated and fully disappeared for Emdogain-treated group. Progressive inflammation and total pulp degeneration were only evident with Emdogain-treated group. The root apices of Emdogain-treated teeth became matured and closed by cementum that attached to new alveolar bone by a well-oriented periodontal ligament. In young permanent dentition, Emdogain could be a good candidate for periodontium but not dentino-pulpal complex regeneration.

No MeSH data available.


Related in: MedlinePlus

(a) Dentin bridge thickness (mm) and (b) apical width (mm) of teeth treated with Emdogain gel and Ca(OH)2 up to 3 months after treatment.EMD: enamel matrix derivative.*Significant difference from 1-month time point.
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fig6-2041731414521707: (a) Dentin bridge thickness (mm) and (b) apical width (mm) of teeth treated with Emdogain gel and Ca(OH)2 up to 3 months after treatment.EMD: enamel matrix derivative.*Significant difference from 1-month time point.

Mentions: Both the Emdogain- and Ca(OH)2-treated groups had a comparable DB thickness after 1 month of treatment. Emdogain-treated group then showed a statistically significant reduction in DB thickness with time until the bridge was completely disappeared by 3 months. The thickness of DB of those treated with Ca(OH)2 increased significantly with time (Figure 6(a)).


Root maturation and dentin-pulp response to enamel matrix derivative in pulpotomized permanent teeth.

Darwish SS, Abd El Meguid SH, Wahba NA, Mohamed AA, Chrzanowski W, Abou Neel EA - J Tissue Eng (2014)

(a) Dentin bridge thickness (mm) and (b) apical width (mm) of teeth treated with Emdogain gel and Ca(OH)2 up to 3 months after treatment.EMD: enamel matrix derivative.*Significant difference from 1-month time point.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3924881&req=5

fig6-2041731414521707: (a) Dentin bridge thickness (mm) and (b) apical width (mm) of teeth treated with Emdogain gel and Ca(OH)2 up to 3 months after treatment.EMD: enamel matrix derivative.*Significant difference from 1-month time point.
Mentions: Both the Emdogain- and Ca(OH)2-treated groups had a comparable DB thickness after 1 month of treatment. Emdogain-treated group then showed a statistically significant reduction in DB thickness with time until the bridge was completely disappeared by 3 months. The thickness of DB of those treated with Ca(OH)2 increased significantly with time (Figure 6(a)).

Bottom Line: The success of pulpotomy of young permanent teeth depends on the proper selection of dressing materials.The root apices of Emdogain-treated teeth became matured and closed by cementum that attached to new alveolar bone by a well-oriented periodontal ligament.In young permanent dentition, Emdogain could be a good candidate for periodontium but not dentino-pulpal complex regeneration.

View Article: PubMed Central - PubMed

Affiliation: Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Pharos University, Egypt.

ABSTRACT
The success of pulpotomy of young permanent teeth depends on the proper selection of dressing materials. This study aimed to evaluate the histological and histomorphometric response of dentin-pulp complex to the enamel matrix derivative (Emdogain(®) gel) compared to that of calcium hydroxide when used as a pulp dressing in immature young permanent dogs' teeth. Dentin-like tissues bridging the full width of the coronal pulp at the interface between the injured and healthy pulp tissues were seen after 1 month in both groups. With time, the dentin bridge increased in thickness for calcium hydroxide but disintegrated and fully disappeared for Emdogain-treated group. Progressive inflammation and total pulp degeneration were only evident with Emdogain-treated group. The root apices of Emdogain-treated teeth became matured and closed by cementum that attached to new alveolar bone by a well-oriented periodontal ligament. In young permanent dentition, Emdogain could be a good candidate for periodontium but not dentino-pulpal complex regeneration.

No MeSH data available.


Related in: MedlinePlus