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SET/MYND Lysine Methyltransferases Regulate Gene Transcription and Protein Activity.

Leinhart K, Brown M - Genes (Basel) (2011)

Bottom Line: While members of the SMYD family are important in the SET-mediated regulation of gene transcription, pathological consequences have also been associated with aberrant expression of SMYD proteins.The last decade has witnessed a rapid increase in the studies and corresponding understanding of these highly impactful enzymes.Herein, we review the current body of knowledge related to the SMYD family of lysine methyltransferases and their role in transcriptional regulation, epigenetics, and tumorigenesis.

View Article: PubMed Central - PubMed

Affiliation: Colorado State University, Fort Collins, CO 80523, USA. kjleinha@rams.colostate.edu.

ABSTRACT
The SET and MYND (SMYD) family of lysine methyltransferases is defined by a SET domain that is split into two segments by a MYND domain, followed by a cysteine-rich post-SET domain. While members of the SMYD family are important in the SET-mediated regulation of gene transcription, pathological consequences have also been associated with aberrant expression of SMYD proteins. The last decade has witnessed a rapid increase in the studies and corresponding understanding of these highly impactful enzymes. Herein, we review the current body of knowledge related to the SMYD family of lysine methyltransferases and their role in transcriptional regulation, epigenetics, and tumorigenesis.

No MeSH data available.


(A) Schematic representation of the five mammalian SMYD proteins. The split SET domain is shown in light gray; the MYND domain is shown in pink; the cysteine-rich post-SET domain is shown in dark gray; (B) ClustalW and BOXSHADE programs were used for alignment and shading of the MYND domains associated with each of the five SMYD proteins.
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f1-genes-02-00210: (A) Schematic representation of the five mammalian SMYD proteins. The split SET domain is shown in light gray; the MYND domain is shown in pink; the cysteine-rich post-SET domain is shown in dark gray; (B) ClustalW and BOXSHADE programs were used for alignment and shading of the MYND domains associated with each of the five SMYD proteins.

Mentions: The SMYD family comprises a subset of five SET domain-containing proteins that have unique domain architecture. Specifically, this family of proteins is defined by a SET domain that is split into two segments by a MYND domain, followed by a cysteine-rich post-SET domain (Figure 1A) [30,31]. The SET domain is responsible for the methylation of lysine residues on target proteins [32–37] and, indeed, the SET domains of SMYDs 1, 2, and 3 have been confirmed to be active catalytic domains despite the split nature of their architecture [14,23,31,38,39].


SET/MYND Lysine Methyltransferases Regulate Gene Transcription and Protein Activity.

Leinhart K, Brown M - Genes (Basel) (2011)

(A) Schematic representation of the five mammalian SMYD proteins. The split SET domain is shown in light gray; the MYND domain is shown in pink; the cysteine-rich post-SET domain is shown in dark gray; (B) ClustalW and BOXSHADE programs were used for alignment and shading of the MYND domains associated with each of the five SMYD proteins.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3924839&req=5

f1-genes-02-00210: (A) Schematic representation of the five mammalian SMYD proteins. The split SET domain is shown in light gray; the MYND domain is shown in pink; the cysteine-rich post-SET domain is shown in dark gray; (B) ClustalW and BOXSHADE programs were used for alignment and shading of the MYND domains associated with each of the five SMYD proteins.
Mentions: The SMYD family comprises a subset of five SET domain-containing proteins that have unique domain architecture. Specifically, this family of proteins is defined by a SET domain that is split into two segments by a MYND domain, followed by a cysteine-rich post-SET domain (Figure 1A) [30,31]. The SET domain is responsible for the methylation of lysine residues on target proteins [32–37] and, indeed, the SET domains of SMYDs 1, 2, and 3 have been confirmed to be active catalytic domains despite the split nature of their architecture [14,23,31,38,39].

Bottom Line: While members of the SMYD family are important in the SET-mediated regulation of gene transcription, pathological consequences have also been associated with aberrant expression of SMYD proteins.The last decade has witnessed a rapid increase in the studies and corresponding understanding of these highly impactful enzymes.Herein, we review the current body of knowledge related to the SMYD family of lysine methyltransferases and their role in transcriptional regulation, epigenetics, and tumorigenesis.

View Article: PubMed Central - PubMed

Affiliation: Colorado State University, Fort Collins, CO 80523, USA. kjleinha@rams.colostate.edu.

ABSTRACT
The SET and MYND (SMYD) family of lysine methyltransferases is defined by a SET domain that is split into two segments by a MYND domain, followed by a cysteine-rich post-SET domain. While members of the SMYD family are important in the SET-mediated regulation of gene transcription, pathological consequences have also been associated with aberrant expression of SMYD proteins. The last decade has witnessed a rapid increase in the studies and corresponding understanding of these highly impactful enzymes. Herein, we review the current body of knowledge related to the SMYD family of lysine methyltransferases and their role in transcriptional regulation, epigenetics, and tumorigenesis.

No MeSH data available.