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Genes involved in type 1 diabetes: an update.

Bakay M, Pandey R, Hakonarson H - Genes (Basel) (2013)

Bottom Line: Historically, prior to genome-wide association studies (GWAS), six loci in the genome were fully established to be associated with T1D.Indeed, recent meta-analyses of multiple datasets from independent investigators have brought the tally of well-validated T1D disease genes to almost 60.In this mini-review, we address recent advances in the genetics of T1D and provide an update on the latest susceptibility loci added to the list of genes involved in the pathogenesis of T1D.

View Article: PubMed Central - PubMed

Affiliation: Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. bakay@email.chop.edu.

ABSTRACT
Type 1 Diabetes (T1D) is a chronic multifactorial disease with a strong genetic component, which, through interactions with specific environmental factors, triggers disease onset. T1D typically manifests in early to mid childhood through the autoimmune destruction of pancreatic β cells resulting in a lack of insulin production. Historically, prior to genome-wide association studies (GWAS), six loci in the genome were fully established to be associated with T1D. With the advent of high-throughput single nucleotide polymorphism (SNP) genotyping array technologies, enabling investigators to perform high-density GWAS, many additional T1D susceptibility genes have been discovered. Indeed, recent meta-analyses of multiple datasets from independent investigators have brought the tally of well-validated T1D disease genes to almost 60. In this mini-review, we address recent advances in the genetics of T1D and provide an update on the latest susceptibility loci added to the list of genes involved in the pathogenesis of T1D.

No MeSH data available.


Related in: MedlinePlus

Pathogenesis model of T1D involves complex interactions between innate and adaptive immune cell types.
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genes-04-00499-f003: Pathogenesis model of T1D involves complex interactions between innate and adaptive immune cell types.

Mentions: The complex crosstalk between innate and adaptive immune cells is broadly categorized in three phases, which results in the development or the prevention of T1D and is illustrated in Figure 3 as a hypothetical model.


Genes involved in type 1 diabetes: an update.

Bakay M, Pandey R, Hakonarson H - Genes (Basel) (2013)

Pathogenesis model of T1D involves complex interactions between innate and adaptive immune cell types.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3924830&req=5

genes-04-00499-f003: Pathogenesis model of T1D involves complex interactions between innate and adaptive immune cell types.
Mentions: The complex crosstalk between innate and adaptive immune cells is broadly categorized in three phases, which results in the development or the prevention of T1D and is illustrated in Figure 3 as a hypothetical model.

Bottom Line: Historically, prior to genome-wide association studies (GWAS), six loci in the genome were fully established to be associated with T1D.Indeed, recent meta-analyses of multiple datasets from independent investigators have brought the tally of well-validated T1D disease genes to almost 60.In this mini-review, we address recent advances in the genetics of T1D and provide an update on the latest susceptibility loci added to the list of genes involved in the pathogenesis of T1D.

View Article: PubMed Central - PubMed

Affiliation: Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. bakay@email.chop.edu.

ABSTRACT
Type 1 Diabetes (T1D) is a chronic multifactorial disease with a strong genetic component, which, through interactions with specific environmental factors, triggers disease onset. T1D typically manifests in early to mid childhood through the autoimmune destruction of pancreatic β cells resulting in a lack of insulin production. Historically, prior to genome-wide association studies (GWAS), six loci in the genome were fully established to be associated with T1D. With the advent of high-throughput single nucleotide polymorphism (SNP) genotyping array technologies, enabling investigators to perform high-density GWAS, many additional T1D susceptibility genes have been discovered. Indeed, recent meta-analyses of multiple datasets from independent investigators have brought the tally of well-validated T1D disease genes to almost 60. In this mini-review, we address recent advances in the genetics of T1D and provide an update on the latest susceptibility loci added to the list of genes involved in the pathogenesis of T1D.

No MeSH data available.


Related in: MedlinePlus