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Residential mobility and breast cancer in Marin County, California, USA.

Jacquez GM, Barlow J, Rommel R, Kaufmann A, Rienti M, AvRuskin G, Rasul J - Int J Environ Res Public Health (2013)

Bottom Line: Analysis found significant global clustering of cases localized to specific residential histories and times.However, persistent case-clustering of greater than fifteen years duration was also detected.A biologically plausible exposure or risk factor has yet to be identified.

View Article: PubMed Central - PubMed

Affiliation: BioMedware, Inc., 3526 West Liberty, Suite 100, Ann Arbor, MI 48103, USA. gjacquez@buffalo.edu.

ABSTRACT
Marin County (California, USA) has among the highest incidences of breast cancer in the U.S. A previously conducted case-control study found eight significant risk factors in participants enrolled from 1997-1999. These included being premenopausal, never using birth control pills, lower highest lifetime body mass index, having four or more mammograms from 1990-1994, beginning drinking alcohol after age 21, drinking an average two or more alcoholic drinks per day, being in the highest quartile of pack-years of cigarette smoking, and being raised in an organized religion. Previously conducted surveys provided residential histories; while statistic accounted for participants' residential mobility, and assessed clustering of breast cancer cases relative to controls based on the known risk factors. These identified specific cases, places, and times of excess breast cancer risk. Analysis found significant global clustering of cases localized to specific residential histories and times. Much of the observed clustering occurred among participants who immigrated to Marin County. However, persistent case-clustering of greater than fifteen years duration was also detected. Significant case-clustering among long-term residents may indicate geographically localized risk factors not accounted for in the study design, as well as uncertainty and incompleteness in the acquired addresses. Other plausible explanations include environmental risk factors and cases tending to settle in specific areas. A biologically plausible exposure or risk factor has yet to be identified.

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Related in: MedlinePlus

Life course clusters in Epoch 1. Locations of cases with significant clustering over their life course at the end of Epoch 1. Five cases had residential history data recorded on 2-1-1968. One case with significant clustering resided in Marin County (upper left), two were in the Bay area (bottom), and two in the Northeast near Long Island (upper right).
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ijerph-11-00271-f007: Life course clusters in Epoch 1. Locations of cases with significant clustering over their life course at the end of Epoch 1. Five cases had residential history data recorded on 2-1-1968. One case with significant clustering resided in Marin County (upper left), two were in the Bay area (bottom), and two in the Northeast near Long Island (upper right).

Mentions: To address this question residential histories of the cases and controls were mapped, and the 16 cases with the smallest p-values for Ǫi (life course clustering) were identified. Visual examination of the geographic distribution of these 16 cases was performed focusing on epochs 1 (Figure 7) and 3 (Figure 8).


Residential mobility and breast cancer in Marin County, California, USA.

Jacquez GM, Barlow J, Rommel R, Kaufmann A, Rienti M, AvRuskin G, Rasul J - Int J Environ Res Public Health (2013)

Life course clusters in Epoch 1. Locations of cases with significant clustering over their life course at the end of Epoch 1. Five cases had residential history data recorded on 2-1-1968. One case with significant clustering resided in Marin County (upper left), two were in the Bay area (bottom), and two in the Northeast near Long Island (upper right).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3924444&req=5

ijerph-11-00271-f007: Life course clusters in Epoch 1. Locations of cases with significant clustering over their life course at the end of Epoch 1. Five cases had residential history data recorded on 2-1-1968. One case with significant clustering resided in Marin County (upper left), two were in the Bay area (bottom), and two in the Northeast near Long Island (upper right).
Mentions: To address this question residential histories of the cases and controls were mapped, and the 16 cases with the smallest p-values for Ǫi (life course clustering) were identified. Visual examination of the geographic distribution of these 16 cases was performed focusing on epochs 1 (Figure 7) and 3 (Figure 8).

Bottom Line: Analysis found significant global clustering of cases localized to specific residential histories and times.However, persistent case-clustering of greater than fifteen years duration was also detected.A biologically plausible exposure or risk factor has yet to be identified.

View Article: PubMed Central - PubMed

Affiliation: BioMedware, Inc., 3526 West Liberty, Suite 100, Ann Arbor, MI 48103, USA. gjacquez@buffalo.edu.

ABSTRACT
Marin County (California, USA) has among the highest incidences of breast cancer in the U.S. A previously conducted case-control study found eight significant risk factors in participants enrolled from 1997-1999. These included being premenopausal, never using birth control pills, lower highest lifetime body mass index, having four or more mammograms from 1990-1994, beginning drinking alcohol after age 21, drinking an average two or more alcoholic drinks per day, being in the highest quartile of pack-years of cigarette smoking, and being raised in an organized religion. Previously conducted surveys provided residential histories; while statistic accounted for participants' residential mobility, and assessed clustering of breast cancer cases relative to controls based on the known risk factors. These identified specific cases, places, and times of excess breast cancer risk. Analysis found significant global clustering of cases localized to specific residential histories and times. Much of the observed clustering occurred among participants who immigrated to Marin County. However, persistent case-clustering of greater than fifteen years duration was also detected. Significant case-clustering among long-term residents may indicate geographically localized risk factors not accounted for in the study design, as well as uncertainty and incompleteness in the acquired addresses. Other plausible explanations include environmental risk factors and cases tending to settle in specific areas. A biologically plausible exposure or risk factor has yet to be identified.

Show MeSH
Related in: MedlinePlus