Limits...
Moderate relationships between NAA and cognitive ability in healthy adults: implications for cognitive spectroscopy.

Patel T, Blyth JC, Griffiths G, Kelly D, Talcott JB - Front Hum Neurosci (2014)

Bottom Line: In this study, we used (1)H-MRS to interrogate single-voxels in occipitoparietal and frontal cortex, in parallel with assessments of psychometric intelligence, in a sample of 40 healthy adult participants.We found correlations between NAA and IQ that were within the range reported in previous studies.However, the magnitude of these effects was significantly modulated by the stringency of data screening and the extent to which outlying values contributed to statistical analyses. (1)H-MRS offers a sensitive tool for assessing neurochemistry non-invasively, yet the relationships between brain metabolites and broad aspects of human behavior such as IQ are subtle.

View Article: PubMed Central - PubMed

Affiliation: Aston Brain Centre, School of Life and Health Sciences, Aston University Birmingham, UK.

ABSTRACT

Background: Proton Magnetic Resonance Spectroscopy ((1)H-MRS) is a non-invasive imaging technique that enables quantification of neurochemistry in vivo and thereby facilitates investigation of the biochemical underpinnings of human cognitive variability. Studies in the field of cognitive spectroscopy have commonly focused on relationships between measures of N-acetyl aspartate (NAA), a surrogate marker of neuronal health and function, and broad measures of cognitive performance, such as IQ.

Methodology/principal findings: In this study, we used (1)H-MRS to interrogate single-voxels in occipitoparietal and frontal cortex, in parallel with assessments of psychometric intelligence, in a sample of 40 healthy adult participants. We found correlations between NAA and IQ that were within the range reported in previous studies. However, the magnitude of these effects was significantly modulated by the stringency of data screening and the extent to which outlying values contributed to statistical analyses.

Conclusions/significance: (1)H-MRS offers a sensitive tool for assessing neurochemistry non-invasively, yet the relationships between brain metabolites and broad aspects of human behavior such as IQ are subtle. We highlight the need to develop an increasingly rigorous analytical and interpretive framework for collecting and reporting data obtained from cognitive spectroscopy studies of this kind.

No MeSH data available.


(A) Approximate localization of 1H-MRS voxels in frontal (FRO) and occipitoparietal (OP) cortex shown in the sagittal and axial planes with a 5-plane localizer (TR = 20 ms, TE = 5 ms, 10 slices at 5 mm thickness). (B) Representative 1H-MRS spectrum from a FRO voxel; Original data shown with the LModeled data overlaid (heavy line).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3924143&req=5

Figure 1: (A) Approximate localization of 1H-MRS voxels in frontal (FRO) and occipitoparietal (OP) cortex shown in the sagittal and axial planes with a 5-plane localizer (TR = 20 ms, TE = 5 ms, 10 slices at 5 mm thickness). (B) Representative 1H-MRS spectrum from a FRO voxel; Original data shown with the LModeled data overlaid (heavy line).

Mentions: The 1H-MRS data were obtained with a Siemens 3T Trio scanner (Siemens Medical Solutions, Berkshire, UK) using standard acquisition software and a quadrature head coil. Single-voxel 1H-MRS was performed following localization of the volume (8 cm3) of interest using a 5-plane localizer (TR = 20 ms, TE = 5 ms, 10 slices at 5 mm thickness). For the left frontal (FRO) VOI, the voxel was positioned in the anterior cerebrum, centered superior to the lateral ventricles and avoiding overlap with non-neural sources and the corpus callosum. For the left occipitoparietal (OP) VOI, the voxel was placed in a region encompassing both occipital cortex and the inferior parietal lobule, with placement positioned to avoid overlap with the cerebellum (see Figure 1A). Manual voxel positioning maximized the contribution from white matter and minimized the contribution from gray matter. Automated shimming was followed by a STEAM pulse sequence (TR = 2000 ms, TE = 30 ms, 96 averages), including water suppression, for both frontal and occipitoparietal voxel acquisitions.


Moderate relationships between NAA and cognitive ability in healthy adults: implications for cognitive spectroscopy.

Patel T, Blyth JC, Griffiths G, Kelly D, Talcott JB - Front Hum Neurosci (2014)

(A) Approximate localization of 1H-MRS voxels in frontal (FRO) and occipitoparietal (OP) cortex shown in the sagittal and axial planes with a 5-plane localizer (TR = 20 ms, TE = 5 ms, 10 slices at 5 mm thickness). (B) Representative 1H-MRS spectrum from a FRO voxel; Original data shown with the LModeled data overlaid (heavy line).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3924143&req=5

Figure 1: (A) Approximate localization of 1H-MRS voxels in frontal (FRO) and occipitoparietal (OP) cortex shown in the sagittal and axial planes with a 5-plane localizer (TR = 20 ms, TE = 5 ms, 10 slices at 5 mm thickness). (B) Representative 1H-MRS spectrum from a FRO voxel; Original data shown with the LModeled data overlaid (heavy line).
Mentions: The 1H-MRS data were obtained with a Siemens 3T Trio scanner (Siemens Medical Solutions, Berkshire, UK) using standard acquisition software and a quadrature head coil. Single-voxel 1H-MRS was performed following localization of the volume (8 cm3) of interest using a 5-plane localizer (TR = 20 ms, TE = 5 ms, 10 slices at 5 mm thickness). For the left frontal (FRO) VOI, the voxel was positioned in the anterior cerebrum, centered superior to the lateral ventricles and avoiding overlap with non-neural sources and the corpus callosum. For the left occipitoparietal (OP) VOI, the voxel was placed in a region encompassing both occipital cortex and the inferior parietal lobule, with placement positioned to avoid overlap with the cerebellum (see Figure 1A). Manual voxel positioning maximized the contribution from white matter and minimized the contribution from gray matter. Automated shimming was followed by a STEAM pulse sequence (TR = 2000 ms, TE = 30 ms, 96 averages), including water suppression, for both frontal and occipitoparietal voxel acquisitions.

Bottom Line: In this study, we used (1)H-MRS to interrogate single-voxels in occipitoparietal and frontal cortex, in parallel with assessments of psychometric intelligence, in a sample of 40 healthy adult participants.We found correlations between NAA and IQ that were within the range reported in previous studies.However, the magnitude of these effects was significantly modulated by the stringency of data screening and the extent to which outlying values contributed to statistical analyses. (1)H-MRS offers a sensitive tool for assessing neurochemistry non-invasively, yet the relationships between brain metabolites and broad aspects of human behavior such as IQ are subtle.

View Article: PubMed Central - PubMed

Affiliation: Aston Brain Centre, School of Life and Health Sciences, Aston University Birmingham, UK.

ABSTRACT

Background: Proton Magnetic Resonance Spectroscopy ((1)H-MRS) is a non-invasive imaging technique that enables quantification of neurochemistry in vivo and thereby facilitates investigation of the biochemical underpinnings of human cognitive variability. Studies in the field of cognitive spectroscopy have commonly focused on relationships between measures of N-acetyl aspartate (NAA), a surrogate marker of neuronal health and function, and broad measures of cognitive performance, such as IQ.

Methodology/principal findings: In this study, we used (1)H-MRS to interrogate single-voxels in occipitoparietal and frontal cortex, in parallel with assessments of psychometric intelligence, in a sample of 40 healthy adult participants. We found correlations between NAA and IQ that were within the range reported in previous studies. However, the magnitude of these effects was significantly modulated by the stringency of data screening and the extent to which outlying values contributed to statistical analyses.

Conclusions/significance: (1)H-MRS offers a sensitive tool for assessing neurochemistry non-invasively, yet the relationships between brain metabolites and broad aspects of human behavior such as IQ are subtle. We highlight the need to develop an increasingly rigorous analytical and interpretive framework for collecting and reporting data obtained from cognitive spectroscopy studies of this kind.

No MeSH data available.