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Diurnal temperature range is a risk factor for coronary heart disease death.

Cao J, Cheng Y, Zhao N, Song W, Jiang C, Chen R, Kan H - J Epidemiol (2009)

Bottom Line: Both time-series and case-crossover analyses showed that DTR was significantly associated with the number of daily deaths related to CHD.A 1 degrees C increase in 2-day lagged DTR corresponded to a 2.46% (95% CI, 1.76% to 3.16%) increase in CHD mortality on time-series analysis, a 3.21% (95% CI, 2.23% to 4.19%) increase on unidirectional case-crossover analysis, and a 2.13% (95% CI, 1.04% to 3.22%) increase on bidirectional case-crossover analysis.Our findings suggest that DTR is an independent risk factor for acute CHD death.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Fourth Affiliated Hospital of Nantong University, Yancheng, China.

ABSTRACT

Background: Although the relation between day-to-day temperature change and coronary heart disease (CHD) mortality is well established, it is unknown whether temperature variation within 1 day, ie, diurnal temperature range (DTR), is an independent risk factor for acute CHD death.

Methods: We used time-series and case-crossover approaches to assess the relation between DTR and daily CHD mortality between 2001 and 2004 in Shanghai, China. Specifically, we used exposures averaged over periods varying from 1 to 5 days to assess the effects of DTR on CHD mortality. We estimated the percent increase in the number of daily deaths related to CHD that were associated with DTR, after adjustment for daily meteorologic conditions (temperature and relative humidity) and levels of outdoor air pollutants.

Results: Both time-series and case-crossover analyses showed that DTR was significantly associated with the number of daily deaths related to CHD. A 1 degrees C increase in 2-day lagged DTR corresponded to a 2.46% (95% CI, 1.76% to 3.16%) increase in CHD mortality on time-series analysis, a 3.21% (95% CI, 2.23% to 4.19%) increase on unidirectional case-crossover analysis, and a 2.13% (95% CI, 1.04% to 3.22%) increase on bidirectional case-crossover analysis.

Conclusions: Our findings suggest that DTR is an independent risk factor for acute CHD death.

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Related in: MedlinePlus

A smoothing plot demonstrating the association between DTR and CHD mortality (df = 5) on time-series analysis; the X-axis depicts DTR (°C). The estimated mean percent change in daily CHD mortality is shown by the solid line; the dotted lines represent pointwise twice-standard-error bands
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fig01: A smoothing plot demonstrating the association between DTR and CHD mortality (df = 5) on time-series analysis; the X-axis depicts DTR (°C). The estimated mean percent change in daily CHD mortality is shown by the solid line; the dotted lines represent pointwise twice-standard-error bands

Mentions: Figure 1 shows the exposure–response relationships between DTR and CHD mortality at the best lagged-day (df = 5) in the time-series analysis. The associations were essentially linear for of the entire range of observed DTR values, which suggests that there is no threshold level for the association between DTR and CHD mortality.


Diurnal temperature range is a risk factor for coronary heart disease death.

Cao J, Cheng Y, Zhao N, Song W, Jiang C, Chen R, Kan H - J Epidemiol (2009)

A smoothing plot demonstrating the association between DTR and CHD mortality (df = 5) on time-series analysis; the X-axis depicts DTR (°C). The estimated mean percent change in daily CHD mortality is shown by the solid line; the dotted lines represent pointwise twice-standard-error bands
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3924102&req=5

fig01: A smoothing plot demonstrating the association between DTR and CHD mortality (df = 5) on time-series analysis; the X-axis depicts DTR (°C). The estimated mean percent change in daily CHD mortality is shown by the solid line; the dotted lines represent pointwise twice-standard-error bands
Mentions: Figure 1 shows the exposure–response relationships between DTR and CHD mortality at the best lagged-day (df = 5) in the time-series analysis. The associations were essentially linear for of the entire range of observed DTR values, which suggests that there is no threshold level for the association between DTR and CHD mortality.

Bottom Line: Both time-series and case-crossover analyses showed that DTR was significantly associated with the number of daily deaths related to CHD.A 1 degrees C increase in 2-day lagged DTR corresponded to a 2.46% (95% CI, 1.76% to 3.16%) increase in CHD mortality on time-series analysis, a 3.21% (95% CI, 2.23% to 4.19%) increase on unidirectional case-crossover analysis, and a 2.13% (95% CI, 1.04% to 3.22%) increase on bidirectional case-crossover analysis.Our findings suggest that DTR is an independent risk factor for acute CHD death.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Fourth Affiliated Hospital of Nantong University, Yancheng, China.

ABSTRACT

Background: Although the relation between day-to-day temperature change and coronary heart disease (CHD) mortality is well established, it is unknown whether temperature variation within 1 day, ie, diurnal temperature range (DTR), is an independent risk factor for acute CHD death.

Methods: We used time-series and case-crossover approaches to assess the relation between DTR and daily CHD mortality between 2001 and 2004 in Shanghai, China. Specifically, we used exposures averaged over periods varying from 1 to 5 days to assess the effects of DTR on CHD mortality. We estimated the percent increase in the number of daily deaths related to CHD that were associated with DTR, after adjustment for daily meteorologic conditions (temperature and relative humidity) and levels of outdoor air pollutants.

Results: Both time-series and case-crossover analyses showed that DTR was significantly associated with the number of daily deaths related to CHD. A 1 degrees C increase in 2-day lagged DTR corresponded to a 2.46% (95% CI, 1.76% to 3.16%) increase in CHD mortality on time-series analysis, a 3.21% (95% CI, 2.23% to 4.19%) increase on unidirectional case-crossover analysis, and a 2.13% (95% CI, 1.04% to 3.22%) increase on bidirectional case-crossover analysis.

Conclusions: Our findings suggest that DTR is an independent risk factor for acute CHD death.

Show MeSH
Related in: MedlinePlus