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Recurrent and progressive abdominal pain and enteritis in a Japanese patient with paroxysmal nocturnal hemoglobinuria.

Hino A, Yamashita Y, Yamaguchi M, Azenishi Y - Case Rep Hematol (2014)

Bottom Line: This case report describes a young male patient with recurrent abdominal pain persisting for more than 16 months.Clinical investigations showed signs of inflammation and pancytopenia.The patient started treatment with the complement inhibitor eculizumab shortly after it was approved for use in Japanese PNH patients with hemolysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Minoh City Hospital, 7-1 Kayano 5-chome, Minoh City, Osaka 562-0014, Japan.

ABSTRACT
This case report describes a young male patient with recurrent abdominal pain persisting for more than 16 months. Clinical investigations showed signs of inflammation and pancytopenia. A diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) was made 9 months after the onset of the abdominal pain, following endoscopic examinations that revealed evidence of a previously unknown hemorrhage. Regular monitoring indicated that the abdominal pain was associated with elevations in lactate dehydrogenase, C-reactive proteins, and D-dimer levels. The patient started treatment with the complement inhibitor eculizumab shortly after it was approved for use in Japanese PNH patients with hemolysis. Resolution of the abdominal pain and normalization of clinical parameters were noted within 3 weeks from treatment initiation.

No MeSH data available.


Related in: MedlinePlus

(a) CT scan in December 2009; thickening of small intestine wall is circled. (b) Contrast-enhanced CT scan in February 2010; edema-like contrast effect of intestinal wall thickening is circled.
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fig1: (a) CT scan in December 2009; thickening of small intestine wall is circled. (b) Contrast-enhanced CT scan in February 2010; edema-like contrast effect of intestinal wall thickening is circled.

Mentions: A computerized tomography (CT) abdominal scan revealed intermittent (full thickness) thickening of the small intestinal wall (Figure 1(a)). Two months later, in February 2010, a follow-up, contrast-enhanced CT scan showed a different distribution of intestinal thickening, with an edema-like contrast effect seen in the thickened intestinal tract (Figure 1(b)).


Recurrent and progressive abdominal pain and enteritis in a Japanese patient with paroxysmal nocturnal hemoglobinuria.

Hino A, Yamashita Y, Yamaguchi M, Azenishi Y - Case Rep Hematol (2014)

(a) CT scan in December 2009; thickening of small intestine wall is circled. (b) Contrast-enhanced CT scan in February 2010; edema-like contrast effect of intestinal wall thickening is circled.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921955&req=5

fig1: (a) CT scan in December 2009; thickening of small intestine wall is circled. (b) Contrast-enhanced CT scan in February 2010; edema-like contrast effect of intestinal wall thickening is circled.
Mentions: A computerized tomography (CT) abdominal scan revealed intermittent (full thickness) thickening of the small intestinal wall (Figure 1(a)). Two months later, in February 2010, a follow-up, contrast-enhanced CT scan showed a different distribution of intestinal thickening, with an edema-like contrast effect seen in the thickened intestinal tract (Figure 1(b)).

Bottom Line: This case report describes a young male patient with recurrent abdominal pain persisting for more than 16 months.Clinical investigations showed signs of inflammation and pancytopenia.The patient started treatment with the complement inhibitor eculizumab shortly after it was approved for use in Japanese PNH patients with hemolysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Minoh City Hospital, 7-1 Kayano 5-chome, Minoh City, Osaka 562-0014, Japan.

ABSTRACT
This case report describes a young male patient with recurrent abdominal pain persisting for more than 16 months. Clinical investigations showed signs of inflammation and pancytopenia. A diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) was made 9 months after the onset of the abdominal pain, following endoscopic examinations that revealed evidence of a previously unknown hemorrhage. Regular monitoring indicated that the abdominal pain was associated with elevations in lactate dehydrogenase, C-reactive proteins, and D-dimer levels. The patient started treatment with the complement inhibitor eculizumab shortly after it was approved for use in Japanese PNH patients with hemolysis. Resolution of the abdominal pain and normalization of clinical parameters were noted within 3 weeks from treatment initiation.

No MeSH data available.


Related in: MedlinePlus