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Two Cases of Metastatic Parathyroid Carcinoma in Male C3H Mice Following Irradiation.

Ohmachi Y, Yoshida M, Ogiu T - J Toxicol Pathol (2013)

Bottom Line: Mitotic figures were frequently observed.Metastasis to the renal cortex was observed in both cases.These cases were diagnosed as parathyroid carcinoma.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Radiological Sciences, Anagawa 4-9-1, Inage-ku, Chiba 263-8555, Japan.

ABSTRACT
White nodules were observed in the thyroid in two male C3H mice (at 99 and 122 weeks of age) exposed to fast neutrons at the age of 8 weeks. Histopathologically, in both cases, tumors were developed in the region corresponding to the parathyroid gland, and the tumor cells were arranged in a solid sheet or nest-like structures. Necrosis, cell debris and/or hemorrhage were sometimes seen in the center of the tumor structures. Tumor cells were small and uniform with scanty cytoplasm, cell margins were indistinct, and basally located tumor cells were aligned along the vascular stroma. Mitotic figures were frequently observed. Metastasis to the renal cortex was observed in both cases. These cases were diagnosed as parathyroid carcinoma. A parathyroid tumor is an extremely rare endocrine tumor in mice, regardless of whether the tumor is spontaneous or experimentally induced. These cases may have been induced by neutron-exposure; however, how radiation induces parathyroid carcinoma in mice is not clear.

No MeSH data available.


Related in: MedlinePlus

PTHimmunostaining. a: Weak PTH-positive cells were seen in the normal parathyroid gland ofCase2 (original magnification, ×20). b: PTH-negative staining was observed in theneoplastic parathyroid gland of Case 2 (original magnification,×20).
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fig_006: PTHimmunostaining. a: Weak PTH-positive cells were seen in the normal parathyroid gland ofCase2 (original magnification, ×20). b: PTH-negative staining was observed in theneoplastic parathyroid gland of Case 2 (original magnification,×20).

Mentions: PCNAimmunostaining. a: Many PCNA-positive tumor cells were seen in Case 1. Tumor cells inthe center of the nodule were usually negative for PCNA-staining (originalmagnification, ×20). b: No PCNA-positive cells were seen on the opposite side of theparathyroid gland (normal parathyroid gland) of Case 2 (original magnification,×20).


Two Cases of Metastatic Parathyroid Carcinoma in Male C3H Mice Following Irradiation.

Ohmachi Y, Yoshida M, Ogiu T - J Toxicol Pathol (2013)

PTHimmunostaining. a: Weak PTH-positive cells were seen in the normal parathyroid gland ofCase2 (original magnification, ×20). b: PTH-negative staining was observed in theneoplastic parathyroid gland of Case 2 (original magnification,×20).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921924&req=5

fig_006: PTHimmunostaining. a: Weak PTH-positive cells were seen in the normal parathyroid gland ofCase2 (original magnification, ×20). b: PTH-negative staining was observed in theneoplastic parathyroid gland of Case 2 (original magnification,×20).
Mentions: PCNAimmunostaining. a: Many PCNA-positive tumor cells were seen in Case 1. Tumor cells inthe center of the nodule were usually negative for PCNA-staining (originalmagnification, ×20). b: No PCNA-positive cells were seen on the opposite side of theparathyroid gland (normal parathyroid gland) of Case 2 (original magnification,×20).

Bottom Line: Mitotic figures were frequently observed.Metastasis to the renal cortex was observed in both cases.These cases were diagnosed as parathyroid carcinoma.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Radiological Sciences, Anagawa 4-9-1, Inage-ku, Chiba 263-8555, Japan.

ABSTRACT
White nodules were observed in the thyroid in two male C3H mice (at 99 and 122 weeks of age) exposed to fast neutrons at the age of 8 weeks. Histopathologically, in both cases, tumors were developed in the region corresponding to the parathyroid gland, and the tumor cells were arranged in a solid sheet or nest-like structures. Necrosis, cell debris and/or hemorrhage were sometimes seen in the center of the tumor structures. Tumor cells were small and uniform with scanty cytoplasm, cell margins were indistinct, and basally located tumor cells were aligned along the vascular stroma. Mitotic figures were frequently observed. Metastasis to the renal cortex was observed in both cases. These cases were diagnosed as parathyroid carcinoma. A parathyroid tumor is an extremely rare endocrine tumor in mice, regardless of whether the tumor is spontaneous or experimentally induced. These cases may have been induced by neutron-exposure; however, how radiation induces parathyroid carcinoma in mice is not clear.

No MeSH data available.


Related in: MedlinePlus