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Radiography finding in the jaws in children taking bisphosphonate.

Moeini M, Moeini M, Lotfizadeh N, Alavi M - Iran J Ped Hematol Oncol (2013)

Bottom Line: Bisphosphonates‎ inhibit osteoclasts, prevent bone resorption and decrease bone turnover.Finally in 2 children (16.6 %) were found oroantral fistula.This sclerosis had different views that thickening of the lamina dura and alveolar crest were most common.

View Article: PubMed Central - PubMed

Affiliation: Resident of Oral and Maxillofacial Radiology, Faculty of Dentistry, Shahid Sadoughi University of Medical Science and Health Services, Yazd, Iran.

ABSTRACT

Background: Bisphosphonates‎ inhibit osteoclasts, prevent bone resorption and decrease bone turnover. This study examined radiography finding in bisphosphonate-associated osteonecrosis of jaws.

Materials and methods: This is a retrospective series of 12 clinically diagnosed patients between 7 to 21 year old (average 13 years). They required emergency dental conditions requiring management by dentist: non healing ‎extraction sockets and pain of bone exposure. The panoramic radiography and cone beam computed tomography was performed ‎to assess the problem. Thickening of the lamina dura was observed in 7 patients (58.3 %). But full-thickness sclerosis was seen in 6 patients (50 %). Sclerotic changes in the mandibular canal were noted in 3 patients (25 %). 5 patients (41.6 %) had poorly healing or non-healing of socket in extracted tooth and periapical lucencies. 4 people (33.3 %) had widening of periodontal ligament (PDL) space and osteolysis. Sequestra were seen in 3 persons (25 %). Finally in 2 children (16.6 %) were found oroantral fistula. Only one child (8.3 %) had thickening of soft tissue mid periosteal reaction.

Results: Most patients had some degree of osteosclerosis, especially in the area of alveolar bone. Thickening of the lamina dura was also seen in children. Other findings include: osteolysis, sequestra, periosteal new bone formation, widening of PDL,soft tissue thickening, non healing extraction sockets, oroantral fistula and periapical lucencies (P-value < 0.05).

Conclusion: Common radiographic features in patients taking bisphosphonate, was osteosclerosis. This sclerosis had different views that thickening of the lamina dura and alveolar crest were most common.

No MeSH data available.


Related in: MedlinePlus

Periapical radiographs of a woman, showing generalized osseous sclerosis ‎of uniform thickness involving the cortical plate and lamina dura. A and C radiographs shows the ‎pre-bisphosphonate therapy condition of the cortical plates and the lamina dura. B and D ‎radiographs shows thickening of the cortical plate and lamina dura after 2 years bisphosphonate ‎therapy. No clinical signs and symptoms were established at this initial stage
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Figure 1: Periapical radiographs of a woman, showing generalized osseous sclerosis ‎of uniform thickness involving the cortical plate and lamina dura. A and C radiographs shows the ‎pre-bisphosphonate therapy condition of the cortical plates and the lamina dura. B and D ‎radiographs shows thickening of the cortical plate and lamina dura after 2 years bisphosphonate ‎therapy. No clinical signs and symptoms were established at this initial stage

Mentions: Common radiographic features were "osteosclerosis" (sclerosing of the alveolar margin and thickening of the lamina dura) similar to the study by Marx et al (19) (figure 1). Usually sizes of bone defects are larger than clinical lesions. In more advanced patients were seen higher degrees of sclerosis (figure 2, 3), which were very similar to osteopetrosis. In large lesions was seen "narrowing of the inferior alveolar canal". We think that generalized nature of BOJ help radiologist to recognize these lesions from localized reactive sclerosis around the inflammatory center.


Radiography finding in the jaws in children taking bisphosphonate.

Moeini M, Moeini M, Lotfizadeh N, Alavi M - Iran J Ped Hematol Oncol (2013)

Periapical radiographs of a woman, showing generalized osseous sclerosis ‎of uniform thickness involving the cortical plate and lamina dura. A and C radiographs shows the ‎pre-bisphosphonate therapy condition of the cortical plates and the lamina dura. B and D ‎radiographs shows thickening of the cortical plate and lamina dura after 2 years bisphosphonate ‎therapy. No clinical signs and symptoms were established at this initial stage
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921879&req=5

Figure 1: Periapical radiographs of a woman, showing generalized osseous sclerosis ‎of uniform thickness involving the cortical plate and lamina dura. A and C radiographs shows the ‎pre-bisphosphonate therapy condition of the cortical plates and the lamina dura. B and D ‎radiographs shows thickening of the cortical plate and lamina dura after 2 years bisphosphonate ‎therapy. No clinical signs and symptoms were established at this initial stage
Mentions: Common radiographic features were "osteosclerosis" (sclerosing of the alveolar margin and thickening of the lamina dura) similar to the study by Marx et al (19) (figure 1). Usually sizes of bone defects are larger than clinical lesions. In more advanced patients were seen higher degrees of sclerosis (figure 2, 3), which were very similar to osteopetrosis. In large lesions was seen "narrowing of the inferior alveolar canal". We think that generalized nature of BOJ help radiologist to recognize these lesions from localized reactive sclerosis around the inflammatory center.

Bottom Line: Bisphosphonates‎ inhibit osteoclasts, prevent bone resorption and decrease bone turnover.Finally in 2 children (16.6 %) were found oroantral fistula.This sclerosis had different views that thickening of the lamina dura and alveolar crest were most common.

View Article: PubMed Central - PubMed

Affiliation: Resident of Oral and Maxillofacial Radiology, Faculty of Dentistry, Shahid Sadoughi University of Medical Science and Health Services, Yazd, Iran.

ABSTRACT

Background: Bisphosphonates‎ inhibit osteoclasts, prevent bone resorption and decrease bone turnover. This study examined radiography finding in bisphosphonate-associated osteonecrosis of jaws.

Materials and methods: This is a retrospective series of 12 clinically diagnosed patients between 7 to 21 year old (average 13 years). They required emergency dental conditions requiring management by dentist: non healing ‎extraction sockets and pain of bone exposure. The panoramic radiography and cone beam computed tomography was performed ‎to assess the problem. Thickening of the lamina dura was observed in 7 patients (58.3 %). But full-thickness sclerosis was seen in 6 patients (50 %). Sclerotic changes in the mandibular canal were noted in 3 patients (25 %). 5 patients (41.6 %) had poorly healing or non-healing of socket in extracted tooth and periapical lucencies. 4 people (33.3 %) had widening of periodontal ligament (PDL) space and osteolysis. Sequestra were seen in 3 persons (25 %). Finally in 2 children (16.6 %) were found oroantral fistula. Only one child (8.3 %) had thickening of soft tissue mid periosteal reaction.

Results: Most patients had some degree of osteosclerosis, especially in the area of alveolar bone. Thickening of the lamina dura was also seen in children. Other findings include: osteolysis, sequestra, periosteal new bone formation, widening of PDL,soft tissue thickening, non healing extraction sockets, oroantral fistula and periapical lucencies (P-value < 0.05).

Conclusion: Common radiographic features in patients taking bisphosphonate, was osteosclerosis. This sclerosis had different views that thickening of the lamina dura and alveolar crest were most common.

No MeSH data available.


Related in: MedlinePlus