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Correlation between seminal lead and cadmium and seminal parameters in idiopathic oligoasthenozoospermic males.

Taha EA, Sayed SK, Ghandour NM, Mahran AM, Saleh MA, Amin MM, Shamloul R - Cent European J Urol (2013)

Bottom Line: The exact causes of the decline in semen quality are not yet known, environmental factors have been considered to play an important role.Lead (Pb) and Cadmium (Cd) are two of the well-known reproductive toxicants to which humans are exposed occupationally and environmentally and can lead to negative effects on the testicular functions.There were significant negative correlations between seminal lead and cadmium levels on one hand and certain semen parameters especially progressive sperm motility and vitality (HOS).

View Article: PubMed Central - PubMed

Affiliation: Departments of Dermatology & Andrology.

ABSTRACT

Introduction: The exact causes of the decline in semen quality are not yet known, environmental factors have been considered to play an important role. Lead (Pb) and Cadmium (Cd) are two of the well-known reproductive toxicants to which humans are exposed occupationally and environmentally and can lead to negative effects on the testicular functions. The aim of this study was to evaluate lead and cadmium levels in seminal plasma of men with idiopathic oligoasthenozoospermia in comparison to fertile healthy controls and to correlate these levels with conventional semen parameters, sperm hypo-osmotic swelling (HOS) percentage, sperm DNA fragmentation percentage, and semen reactive oxygen species (ROS) levels.

Material and methods: Thirty infertile male patients with idiopathic oligo and/or asthenozoospermia and thirty healthy fertile men, which was the control group, were included in the study. Lead and cadmium levels in seminal plasma, semen parameters, sperm HOS, sperm DNA fragmentation percentage and semen ROS assay were measured in all subjects.

Results: There was a significant increase in seminal lead and cadmium levels among infertile males in comparison to controls. There were significant negative correlations between seminal lead and cadmium levels on one hand and certain semen parameters especially progressive sperm motility and vitality (HOS). Importantly, significant positive correlations were noted between seminal lead and cadmium levels on one hand and sperm DNA fragmentation percentage and semen ROS level in infertile men and controls on the other hand.

Conclusions: Thus, men with idiopathic male infertility had higher levels of lead and cadmium in their semen which correlated with impairment of sperm motility and vitality percentages and more importantly with higher sperm DNA fragmentation% and semen ROS level.

No MeSH data available.


Related in: MedlinePlus

Correlation between semen cadmium level and ROS levels in infertile men.
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Figure 0009: Correlation between semen cadmium level and ROS levels in infertile men.

Mentions: Correlations with semen lead level in infertile men and in controls


Correlation between seminal lead and cadmium and seminal parameters in idiopathic oligoasthenozoospermic males.

Taha EA, Sayed SK, Ghandour NM, Mahran AM, Saleh MA, Amin MM, Shamloul R - Cent European J Urol (2013)

Correlation between semen cadmium level and ROS levels in infertile men.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921854&req=5

Figure 0009: Correlation between semen cadmium level and ROS levels in infertile men.
Mentions: Correlations with semen lead level in infertile men and in controls

Bottom Line: The exact causes of the decline in semen quality are not yet known, environmental factors have been considered to play an important role.Lead (Pb) and Cadmium (Cd) are two of the well-known reproductive toxicants to which humans are exposed occupationally and environmentally and can lead to negative effects on the testicular functions.There were significant negative correlations between seminal lead and cadmium levels on one hand and certain semen parameters especially progressive sperm motility and vitality (HOS).

View Article: PubMed Central - PubMed

Affiliation: Departments of Dermatology & Andrology.

ABSTRACT

Introduction: The exact causes of the decline in semen quality are not yet known, environmental factors have been considered to play an important role. Lead (Pb) and Cadmium (Cd) are two of the well-known reproductive toxicants to which humans are exposed occupationally and environmentally and can lead to negative effects on the testicular functions. The aim of this study was to evaluate lead and cadmium levels in seminal plasma of men with idiopathic oligoasthenozoospermia in comparison to fertile healthy controls and to correlate these levels with conventional semen parameters, sperm hypo-osmotic swelling (HOS) percentage, sperm DNA fragmentation percentage, and semen reactive oxygen species (ROS) levels.

Material and methods: Thirty infertile male patients with idiopathic oligo and/or asthenozoospermia and thirty healthy fertile men, which was the control group, were included in the study. Lead and cadmium levels in seminal plasma, semen parameters, sperm HOS, sperm DNA fragmentation percentage and semen ROS assay were measured in all subjects.

Results: There was a significant increase in seminal lead and cadmium levels among infertile males in comparison to controls. There were significant negative correlations between seminal lead and cadmium levels on one hand and certain semen parameters especially progressive sperm motility and vitality (HOS). Importantly, significant positive correlations were noted between seminal lead and cadmium levels on one hand and sperm DNA fragmentation percentage and semen ROS level in infertile men and controls on the other hand.

Conclusions: Thus, men with idiopathic male infertility had higher levels of lead and cadmium in their semen which correlated with impairment of sperm motility and vitality percentages and more importantly with higher sperm DNA fragmentation% and semen ROS level.

No MeSH data available.


Related in: MedlinePlus