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Clinical and laboratory profiles of a large cohort of patients with different grades of varicocele.

Al-Ali BM, Shamloul R, Pichler M, Augustin H, Pummer K - Cent European J Urol (2013)

Bottom Line: The mean age was 28.8 (±7.3) years.Serum testosterone levels and BMI were significantly associated (p <0.05) with the grade of varicocele, but no association was found with the other parameters analyzed.More prospective studies are recommended.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Medical University Graz, Austria.

ABSTRACT

Objective: In this retrospective study we attempted to report our own data on the different clinical parameters in association with the presence and severity of varicocele in a large group of Austrian men.

Methods: The records of 1,111 consecutive patients with clinical varicocele from 1993 to 2010 were evaluated. The presence, grade, and side of any varicocele were recorded. Semen samples, serum FSH, LH, and testosterone levels, and testicular volume were assessed.

Results: The mean age was 28.8 (±7.3) years. Three hundred seventeen (28.5%) patients presented with grade I varicocele, 427 (38.4%) with grade II varicocele, and 367 (33%) with grade III varicocele. Correlation between different grades of varicocele and semen quality indicated an over-representation of oligospermia and asthenoteratospermia in the group of grade III varicocele (p <0.05), whereas other parameters of semen quality showed no significant difference between the three groups. Serum testosterone levels and BMI were significantly associated (p <0.05) with the grade of varicocele, but no association was found with the other parameters analyzed.

Conclusions: Our analysis showed a significant relationship between the grade of varicocele and semen analysis. Moreover, higher testosterone levels and lower body mass index were associated with the higher grade of varicocele and decreased semen quality. More prospective studies are recommended.

No MeSH data available.


Related in: MedlinePlus

Testosterone levels in ng/ml stratified to different grades of varicocele. Means (black dots) and corresponding 95% confidence intervals illustrates the higher the grade of varicocele, the higher the level of testosterone.
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Figure 0001: Testosterone levels in ng/ml stratified to different grades of varicocele. Means (black dots) and corresponding 95% confidence intervals illustrates the higher the grade of varicocele, the higher the level of testosterone.

Mentions: The mean serum concentration of the analyzed endocrine parameters for the whole patient cohort was: FSH 6.5 (±6.2); LH 4.2 (±2.9); testosterone 5.3 (±2.7); estradiol 23.5 (±41.8); and prolactin 13.1 (±17). From the five hormonal parameters, only testosterone concentration was significantly different in grade III varicocele compared to grade I or grade II varicocele (mean value 5.86 ±2.6 versus 5.03 ±3.13 versus 5.14 ±2.27, respectively; p <0.05, Fig. 1). The mean height in the whole cohort was 1.8 (±0.07) meters, the mean weight was 78.8 (±11.8) kg and the mean body mass index was 24.2 (±3.2). A large height, a low body weight, and a low BMI were associated with grade III varicocele (for BMI: 25.1 ±3.3 for grade I, 24.2 ±3.1 for grade II and 23.2 ±2.9, respectively; p <0.05). In a multivariate regression analysis, testosterone concentration and BMI were significantly associated (p <0.05) with the grade of varicocele, but no association was found with the other parameters analyzed.


Clinical and laboratory profiles of a large cohort of patients with different grades of varicocele.

Al-Ali BM, Shamloul R, Pichler M, Augustin H, Pummer K - Cent European J Urol (2013)

Testosterone levels in ng/ml stratified to different grades of varicocele. Means (black dots) and corresponding 95% confidence intervals illustrates the higher the grade of varicocele, the higher the level of testosterone.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921831&req=5

Figure 0001: Testosterone levels in ng/ml stratified to different grades of varicocele. Means (black dots) and corresponding 95% confidence intervals illustrates the higher the grade of varicocele, the higher the level of testosterone.
Mentions: The mean serum concentration of the analyzed endocrine parameters for the whole patient cohort was: FSH 6.5 (±6.2); LH 4.2 (±2.9); testosterone 5.3 (±2.7); estradiol 23.5 (±41.8); and prolactin 13.1 (±17). From the five hormonal parameters, only testosterone concentration was significantly different in grade III varicocele compared to grade I or grade II varicocele (mean value 5.86 ±2.6 versus 5.03 ±3.13 versus 5.14 ±2.27, respectively; p <0.05, Fig. 1). The mean height in the whole cohort was 1.8 (±0.07) meters, the mean weight was 78.8 (±11.8) kg and the mean body mass index was 24.2 (±3.2). A large height, a low body weight, and a low BMI were associated with grade III varicocele (for BMI: 25.1 ±3.3 for grade I, 24.2 ±3.1 for grade II and 23.2 ±2.9, respectively; p <0.05). In a multivariate regression analysis, testosterone concentration and BMI were significantly associated (p <0.05) with the grade of varicocele, but no association was found with the other parameters analyzed.

Bottom Line: The mean age was 28.8 (±7.3) years.Serum testosterone levels and BMI were significantly associated (p <0.05) with the grade of varicocele, but no association was found with the other parameters analyzed.More prospective studies are recommended.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Medical University Graz, Austria.

ABSTRACT

Objective: In this retrospective study we attempted to report our own data on the different clinical parameters in association with the presence and severity of varicocele in a large group of Austrian men.

Methods: The records of 1,111 consecutive patients with clinical varicocele from 1993 to 2010 were evaluated. The presence, grade, and side of any varicocele were recorded. Semen samples, serum FSH, LH, and testosterone levels, and testicular volume were assessed.

Results: The mean age was 28.8 (±7.3) years. Three hundred seventeen (28.5%) patients presented with grade I varicocele, 427 (38.4%) with grade II varicocele, and 367 (33%) with grade III varicocele. Correlation between different grades of varicocele and semen quality indicated an over-representation of oligospermia and asthenoteratospermia in the group of grade III varicocele (p <0.05), whereas other parameters of semen quality showed no significant difference between the three groups. Serum testosterone levels and BMI were significantly associated (p <0.05) with the grade of varicocele, but no association was found with the other parameters analyzed.

Conclusions: Our analysis showed a significant relationship between the grade of varicocele and semen analysis. Moreover, higher testosterone levels and lower body mass index were associated with the higher grade of varicocele and decreased semen quality. More prospective studies are recommended.

No MeSH data available.


Related in: MedlinePlus