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Unfavorable prognosis of nephroblastoma in adults.

Huszno J, Starzyczny-Słota D, Jaworska M, Nowara E - Cent European J Urol (2013)

Bottom Line: Due to the fact that this type of cancer is so rare in adults, however, there is a significant lack of treatment strategies in this age group.Moreover, the treatment of adults is often based on protocols used in children.During the systemic treatment, the authors observed progression of disease and serious side effects.

View Article: PubMed Central - PubMed

Affiliation: Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland.

ABSTRACT
Wilms' tumor is the most common type of malignant kidney tumor in children. Due to the fact that this type of cancer is so rare in adults, however, there is a significant lack of treatment strategies in this age group. Moreover, the treatment of adults is often based on protocols used in children. The present report describes a case of a 25-year-old male with nephroblastoma stage IV, who had a primary surgery and underwent chemotherapy with CDVC (cyclophosphamide, doxorubicin, vepesid, carboplatin). During the systemic treatment, the authors observed progression of disease and serious side effects.

No MeSH data available.


Related in: MedlinePlus

Blastemal component in nephroblastoma. Mitoses and apoptotic bodies. H&E original magnification, 300x.
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Figure 0002: Blastemal component in nephroblastoma. Mitoses and apoptotic bodies. H&E original magnification, 300x.

Mentions: Consultation of histological slides was performed. The tumor was composed mostly of diffuse sheets of blastemal cells with irregular nuclei, numerous mitotic figures, and apoptotic bodies. Focally, there was a cord–like growth pattern and the stromal component was scared. Areas of necrosis were also seen (Figs. 1 & 2). Immunohistochemically, blastemal cells expressed WT1 and were CD 99 negative (Fig. 3). The final diagnosis was: nephroblastoma – blastemal type. The presence of vassal infiltration in the renal sinus (described in the first diagnosis) suggested stage II. The current stage of disease was assessed as stage IV according to the SIOP staging system.


Unfavorable prognosis of nephroblastoma in adults.

Huszno J, Starzyczny-Słota D, Jaworska M, Nowara E - Cent European J Urol (2013)

Blastemal component in nephroblastoma. Mitoses and apoptotic bodies. H&E original magnification, 300x.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921830&req=5

Figure 0002: Blastemal component in nephroblastoma. Mitoses and apoptotic bodies. H&E original magnification, 300x.
Mentions: Consultation of histological slides was performed. The tumor was composed mostly of diffuse sheets of blastemal cells with irregular nuclei, numerous mitotic figures, and apoptotic bodies. Focally, there was a cord–like growth pattern and the stromal component was scared. Areas of necrosis were also seen (Figs. 1 & 2). Immunohistochemically, blastemal cells expressed WT1 and were CD 99 negative (Fig. 3). The final diagnosis was: nephroblastoma – blastemal type. The presence of vassal infiltration in the renal sinus (described in the first diagnosis) suggested stage II. The current stage of disease was assessed as stage IV according to the SIOP staging system.

Bottom Line: Due to the fact that this type of cancer is so rare in adults, however, there is a significant lack of treatment strategies in this age group.Moreover, the treatment of adults is often based on protocols used in children.During the systemic treatment, the authors observed progression of disease and serious side effects.

View Article: PubMed Central - PubMed

Affiliation: Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland.

ABSTRACT
Wilms' tumor is the most common type of malignant kidney tumor in children. Due to the fact that this type of cancer is so rare in adults, however, there is a significant lack of treatment strategies in this age group. Moreover, the treatment of adults is often based on protocols used in children. The present report describes a case of a 25-year-old male with nephroblastoma stage IV, who had a primary surgery and underwent chemotherapy with CDVC (cyclophosphamide, doxorubicin, vepesid, carboplatin). During the systemic treatment, the authors observed progression of disease and serious side effects.

No MeSH data available.


Related in: MedlinePlus