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A high prevalence of extreme hyperferritinemia in acute hepatitis patients.

Kotoh K, Ueda A, Tanaka M, Miyazaki M, Kato M, Kohjima M, Enjoji M, Nakamuta M, Takayanagi R - Hepat Med (2009)

Bottom Line: One hundred consecutive patients with acute liver injury were enrolled, of whom 19 fulfilled the criteria for ALF.Interestingly, the correlation was strong in patients infected by hepatitis viruses, but weak in others.Overactivation of macrophages appears to be essential, but not sufficient, for the development of ALF.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoda, Japan.

ABSTRACT
Although the mechanism underlying acute liver failure (ALF) has not been clarified, recent reports indicate overactivation of macrophages is involved in its progression. In diseases in which activated macrophages participate in the progression, elevated serum ferritin concentration counts among the characteristic laboratory findings. If activated macrophages play a key role in the development of ALF, serum ferritin levels might reflect the severity of acute liver injury. To confirm this, we evaluated the correlation between the serum ferritin concentration and other laboratory measurements in patients with acute hepatitis including ALF. One hundred consecutive patients with acute liver injury were enrolled, of whom 19 fulfilled the criteria for ALF. Serum ferritin concentrations correlated with serum alanine transferase activity as a whole. Interestingly, the correlation was strong in patients infected by hepatitis viruses, but weak in others. Although most patients with ALF had high levels of serum ferritin, not a few patients without ALF showed similar results. The serum ferritin level was generally increased in acute hepatitis patients, probably reflecting the degree of macrophage activation in the liver. Overactivation of macrophages appears to be essential, but not sufficient, for the development of ALF.

No MeSH data available.


Related in: MedlinePlus

The distributions of serum ferritin concentrations (A) and serum alanine aminotransferase (ALT) activities (B) are shown using boxplots. Although the patients who fulfilled the criteria for acute liver failure (ALF) had significantly higher measurements than other patients, the difference was more distinct for the comparison of serum ferritin concentrations.
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f4-hmer-1-001: The distributions of serum ferritin concentrations (A) and serum alanine aminotransferase (ALT) activities (B) are shown using boxplots. Although the patients who fulfilled the criteria for acute liver failure (ALF) had significantly higher measurements than other patients, the difference was more distinct for the comparison of serum ferritin concentrations.

Mentions: On admission, 19 patients fulfilled the criteria for ALF. The differences in the characteristics on admission between patients with and without ALF are shown in Table 1. Naturally, the ALF group had higher serum ALT activities and serum ferritin concentrations than the others. However, this difference was more distinct for the comparison of serum ferritin concentrations (Figure 4). Similarly, in evaluating the correlation between PT-INR and serum ALT activity or ferritin concentration, although both serum ferritin level and ALT activity showed negative correlations with PT-INR, the latter was weaker than the former (Figure 5). These results seem to indicate that serum ferritin concentration more strongly influences the development of ALF than serum ALT activity.


A high prevalence of extreme hyperferritinemia in acute hepatitis patients.

Kotoh K, Ueda A, Tanaka M, Miyazaki M, Kato M, Kohjima M, Enjoji M, Nakamuta M, Takayanagi R - Hepat Med (2009)

The distributions of serum ferritin concentrations (A) and serum alanine aminotransferase (ALT) activities (B) are shown using boxplots. Although the patients who fulfilled the criteria for acute liver failure (ALF) had significantly higher measurements than other patients, the difference was more distinct for the comparison of serum ferritin concentrations.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3921818&req=5

f4-hmer-1-001: The distributions of serum ferritin concentrations (A) and serum alanine aminotransferase (ALT) activities (B) are shown using boxplots. Although the patients who fulfilled the criteria for acute liver failure (ALF) had significantly higher measurements than other patients, the difference was more distinct for the comparison of serum ferritin concentrations.
Mentions: On admission, 19 patients fulfilled the criteria for ALF. The differences in the characteristics on admission between patients with and without ALF are shown in Table 1. Naturally, the ALF group had higher serum ALT activities and serum ferritin concentrations than the others. However, this difference was more distinct for the comparison of serum ferritin concentrations (Figure 4). Similarly, in evaluating the correlation between PT-INR and serum ALT activity or ferritin concentration, although both serum ferritin level and ALT activity showed negative correlations with PT-INR, the latter was weaker than the former (Figure 5). These results seem to indicate that serum ferritin concentration more strongly influences the development of ALF than serum ALT activity.

Bottom Line: One hundred consecutive patients with acute liver injury were enrolled, of whom 19 fulfilled the criteria for ALF.Interestingly, the correlation was strong in patients infected by hepatitis viruses, but weak in others.Overactivation of macrophages appears to be essential, but not sufficient, for the development of ALF.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoda, Japan.

ABSTRACT
Although the mechanism underlying acute liver failure (ALF) has not been clarified, recent reports indicate overactivation of macrophages is involved in its progression. In diseases in which activated macrophages participate in the progression, elevated serum ferritin concentration counts among the characteristic laboratory findings. If activated macrophages play a key role in the development of ALF, serum ferritin levels might reflect the severity of acute liver injury. To confirm this, we evaluated the correlation between the serum ferritin concentration and other laboratory measurements in patients with acute hepatitis including ALF. One hundred consecutive patients with acute liver injury were enrolled, of whom 19 fulfilled the criteria for ALF. Serum ferritin concentrations correlated with serum alanine transferase activity as a whole. Interestingly, the correlation was strong in patients infected by hepatitis viruses, but weak in others. Although most patients with ALF had high levels of serum ferritin, not a few patients without ALF showed similar results. The serum ferritin level was generally increased in acute hepatitis patients, probably reflecting the degree of macrophage activation in the liver. Overactivation of macrophages appears to be essential, but not sufficient, for the development of ALF.

No MeSH data available.


Related in: MedlinePlus