Limits...
A high prevalence of extreme hyperferritinemia in acute hepatitis patients.

Kotoh K, Ueda A, Tanaka M, Miyazaki M, Kato M, Kohjima M, Enjoji M, Nakamuta M, Takayanagi R - Hepat Med (2009)

Bottom Line: One hundred consecutive patients with acute liver injury were enrolled, of whom 19 fulfilled the criteria for ALF.Interestingly, the correlation was strong in patients infected by hepatitis viruses, but weak in others.Overactivation of macrophages appears to be essential, but not sufficient, for the development of ALF.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoda, Japan.

ABSTRACT
Although the mechanism underlying acute liver failure (ALF) has not been clarified, recent reports indicate overactivation of macrophages is involved in its progression. In diseases in which activated macrophages participate in the progression, elevated serum ferritin concentration counts among the characteristic laboratory findings. If activated macrophages play a key role in the development of ALF, serum ferritin levels might reflect the severity of acute liver injury. To confirm this, we evaluated the correlation between the serum ferritin concentration and other laboratory measurements in patients with acute hepatitis including ALF. One hundred consecutive patients with acute liver injury were enrolled, of whom 19 fulfilled the criteria for ALF. Serum ferritin concentrations correlated with serum alanine transferase activity as a whole. Interestingly, the correlation was strong in patients infected by hepatitis viruses, but weak in others. Although most patients with ALF had high levels of serum ferritin, not a few patients without ALF showed similar results. The serum ferritin level was generally increased in acute hepatitis patients, probably reflecting the degree of macrophage activation in the liver. Overactivation of macrophages appears to be essential, but not sufficient, for the development of ALF.

No MeSH data available.


Related in: MedlinePlus

The distribution of serum alanine aminotransferase (ALT) activities (A) and serum ferritin concentrations (B) shown using a cumulative probability plot. The horizontal scale is plotted according to a Gaussian distribution, and the vertical scale is logarithmic. Both variables showed a log-normal distribution.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3921818&req=5

f1-hmer-1-001: The distribution of serum alanine aminotransferase (ALT) activities (A) and serum ferritin concentrations (B) shown using a cumulative probability plot. The horizontal scale is plotted according to a Gaussian distribution, and the vertical scale is logarithmic. Both variables showed a log-normal distribution.

Mentions: The serum ferritin concentrations on admission varied from 45 ng/mL to 876,790 ng/mL, which showed a continuous log-normal distribution (Figure 1). The average for all patients was 23,462.7 ng/mL, and 28 patients (28%) showed levels higher than 10,000 ng/mL.


A high prevalence of extreme hyperferritinemia in acute hepatitis patients.

Kotoh K, Ueda A, Tanaka M, Miyazaki M, Kato M, Kohjima M, Enjoji M, Nakamuta M, Takayanagi R - Hepat Med (2009)

The distribution of serum alanine aminotransferase (ALT) activities (A) and serum ferritin concentrations (B) shown using a cumulative probability plot. The horizontal scale is plotted according to a Gaussian distribution, and the vertical scale is logarithmic. Both variables showed a log-normal distribution.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3921818&req=5

f1-hmer-1-001: The distribution of serum alanine aminotransferase (ALT) activities (A) and serum ferritin concentrations (B) shown using a cumulative probability plot. The horizontal scale is plotted according to a Gaussian distribution, and the vertical scale is logarithmic. Both variables showed a log-normal distribution.
Mentions: The serum ferritin concentrations on admission varied from 45 ng/mL to 876,790 ng/mL, which showed a continuous log-normal distribution (Figure 1). The average for all patients was 23,462.7 ng/mL, and 28 patients (28%) showed levels higher than 10,000 ng/mL.

Bottom Line: One hundred consecutive patients with acute liver injury were enrolled, of whom 19 fulfilled the criteria for ALF.Interestingly, the correlation was strong in patients infected by hepatitis viruses, but weak in others.Overactivation of macrophages appears to be essential, but not sufficient, for the development of ALF.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoda, Japan.

ABSTRACT
Although the mechanism underlying acute liver failure (ALF) has not been clarified, recent reports indicate overactivation of macrophages is involved in its progression. In diseases in which activated macrophages participate in the progression, elevated serum ferritin concentration counts among the characteristic laboratory findings. If activated macrophages play a key role in the development of ALF, serum ferritin levels might reflect the severity of acute liver injury. To confirm this, we evaluated the correlation between the serum ferritin concentration and other laboratory measurements in patients with acute hepatitis including ALF. One hundred consecutive patients with acute liver injury were enrolled, of whom 19 fulfilled the criteria for ALF. Serum ferritin concentrations correlated with serum alanine transferase activity as a whole. Interestingly, the correlation was strong in patients infected by hepatitis viruses, but weak in others. Although most patients with ALF had high levels of serum ferritin, not a few patients without ALF showed similar results. The serum ferritin level was generally increased in acute hepatitis patients, probably reflecting the degree of macrophage activation in the liver. Overactivation of macrophages appears to be essential, but not sufficient, for the development of ALF.

No MeSH data available.


Related in: MedlinePlus