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Clinical significance of surgical margin status in patients subjected to radical prostatectomy.

Dobruch J, Nyk L, Skrzypczyk M, Chłosta P, Dzik T, Borówka A - Cent European J Urol (2012)

Bottom Line: PSM were found in 64 (25%) out of 255 analyzed patients.In contrast, the likelihood of BR was significantly greater in cases of PSM in which maximum longitude exceeded 3 mm.PSM are not inevitably associated with BR.

View Article: PubMed Central - PubMed

Affiliation: Postgraduate Medical Education Center, Department of Urology, European Health Center Otwock, Poland.

ABSTRACT
The aim of this study is to evaluate the clinical value of positive surgical margins (PSM) in patients subjected to radical prostatectomy (RP). The data of men who were subjected to RP from the 1st of January, 2001 to the 30th of May, 2010 were analyzed. Specimens with PSM were again evaluated to confirm the presence of positive margins. PSM were found in 64 (25%) out of 255 analyzed patients. Out of all clinical features, only biopsy Gleason score and clinical stage of the disease were found to be predictive of PSM. Biochemical recurrence (BR) was found in 42 (16.5%) men, among them 17 (26.6%) had PSM and 25 (13.1%) had negative margins. The risk of BR in those with "focal" PSM (<3 mm) did not differ from the risk of BR observed in patients without PSM. In contrast, the likelihood of BR was significantly greater in cases of PSM in which maximum longitude exceeded 3 mm. Reevaluation of the PSM specimens revealed equivocal margins status in six cases. PSM are not inevitably associated with BR. The risk of failure is influenced by their length. Reevaluation of the prostate specimen may lead to surgical margins status modification.

No MeSH data available.


Related in: MedlinePlus

Biochemical progression free survival depending on margin status (NSM – negative surgical margins, fPSM – focal positive surgical margins, ePSM – extensive positive surgical margins).
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Figure 0001: Biochemical progression free survival depending on margin status (NSM – negative surgical margins, fPSM – focal positive surgical margins, ePSM – extensive positive surgical margins).

Mentions: BR was observed in 17 (26.6%) men among those with PSM and in 25 (13.1%) men among those with NSM (p = 0.01). However DFS for those with fPSM did not differ significantly from the survival for those without PSM (Table 2). For both groups, DFS was significantly longer than the survival observed in those with ePSM (Fig. 1).


Clinical significance of surgical margin status in patients subjected to radical prostatectomy.

Dobruch J, Nyk L, Skrzypczyk M, Chłosta P, Dzik T, Borówka A - Cent European J Urol (2012)

Biochemical progression free survival depending on margin status (NSM – negative surgical margins, fPSM – focal positive surgical margins, ePSM – extensive positive surgical margins).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921813&req=5

Figure 0001: Biochemical progression free survival depending on margin status (NSM – negative surgical margins, fPSM – focal positive surgical margins, ePSM – extensive positive surgical margins).
Mentions: BR was observed in 17 (26.6%) men among those with PSM and in 25 (13.1%) men among those with NSM (p = 0.01). However DFS for those with fPSM did not differ significantly from the survival for those without PSM (Table 2). For both groups, DFS was significantly longer than the survival observed in those with ePSM (Fig. 1).

Bottom Line: PSM were found in 64 (25%) out of 255 analyzed patients.In contrast, the likelihood of BR was significantly greater in cases of PSM in which maximum longitude exceeded 3 mm.PSM are not inevitably associated with BR.

View Article: PubMed Central - PubMed

Affiliation: Postgraduate Medical Education Center, Department of Urology, European Health Center Otwock, Poland.

ABSTRACT
The aim of this study is to evaluate the clinical value of positive surgical margins (PSM) in patients subjected to radical prostatectomy (RP). The data of men who were subjected to RP from the 1st of January, 2001 to the 30th of May, 2010 were analyzed. Specimens with PSM were again evaluated to confirm the presence of positive margins. PSM were found in 64 (25%) out of 255 analyzed patients. Out of all clinical features, only biopsy Gleason score and clinical stage of the disease were found to be predictive of PSM. Biochemical recurrence (BR) was found in 42 (16.5%) men, among them 17 (26.6%) had PSM and 25 (13.1%) had negative margins. The risk of BR in those with "focal" PSM (<3 mm) did not differ from the risk of BR observed in patients without PSM. In contrast, the likelihood of BR was significantly greater in cases of PSM in which maximum longitude exceeded 3 mm. Reevaluation of the PSM specimens revealed equivocal margins status in six cases. PSM are not inevitably associated with BR. The risk of failure is influenced by their length. Reevaluation of the prostate specimen may lead to surgical margins status modification.

No MeSH data available.


Related in: MedlinePlus