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Complications following endoscopic treatment of vesicoureteric reflux with Deflux(®) - two case studies.

Zyczkowski M, Prokopowicz G, Zajęcki W, Paradysz A - Cent European J Urol (2012)

Bottom Line: The endoscopic injection of vesicoureteric orifices with synthetic or natural materials is a widely recognized method of treating vesicoureteral reflux (VUR).The aim of this study is to present two cases of clinically significant complications following the use of dextranomer/hyaluronic acid copolymer, which led to the progression of the reflux degree, permanent infection of the urinary tract, and the necessity to perform surgical treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology in Zabrze of the Medical University of Silesia in Katowice, Poland.

ABSTRACT
The endoscopic injection of vesicoureteric orifices with synthetic or natural materials is a widely recognized method of treating vesicoureteral reflux (VUR). The aim of this study is to present two cases of clinically significant complications following the use of dextranomer/hyaluronic acid copolymer, which led to the progression of the reflux degree, permanent infection of the urinary tract, and the necessity to perform surgical treatment.

No MeSH data available.


Related in: MedlinePlus

Transverse section of the ureter in the external muscular layer. Droplets of the iatrogenic substance (Deflux®) surrounded by polynucleic histiocytes. Staining with hematoxylin-eosin. mag. 200x.
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Figure 0001: Transverse section of the ureter in the external muscular layer. Droplets of the iatrogenic substance (Deflux®) surrounded by polynucleic histiocytes. Staining with hematoxylin-eosin. mag. 200x.

Mentions: After the opening of the bladder, a hard inflammatory infiltrate in the area of the vesical ostium was found, which made the intravesical dissection impossible. The left ureter was transplanted using the Politano-Leadbetter method, having previously resected its intraparietal and paraureteral segments affected by the hard infiltrate. The excised 2-centimeter ureteral segment was then sent for histopathological examination, which revealed a significantly exfoliated transitional epithelium with a visible chronic inflammatory lymphocyte infiltrate beneath. Outside the muscular coat, a focus 2-milimeters in diameter was visible (Fig. 1). It was formed by droplets of iatrogenic origin and surrounded by polynucleic histiocytes.


Complications following endoscopic treatment of vesicoureteric reflux with Deflux(®) - two case studies.

Zyczkowski M, Prokopowicz G, Zajęcki W, Paradysz A - Cent European J Urol (2012)

Transverse section of the ureter in the external muscular layer. Droplets of the iatrogenic substance (Deflux®) surrounded by polynucleic histiocytes. Staining with hematoxylin-eosin. mag. 200x.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921807&req=5

Figure 0001: Transverse section of the ureter in the external muscular layer. Droplets of the iatrogenic substance (Deflux®) surrounded by polynucleic histiocytes. Staining with hematoxylin-eosin. mag. 200x.
Mentions: After the opening of the bladder, a hard inflammatory infiltrate in the area of the vesical ostium was found, which made the intravesical dissection impossible. The left ureter was transplanted using the Politano-Leadbetter method, having previously resected its intraparietal and paraureteral segments affected by the hard infiltrate. The excised 2-centimeter ureteral segment was then sent for histopathological examination, which revealed a significantly exfoliated transitional epithelium with a visible chronic inflammatory lymphocyte infiltrate beneath. Outside the muscular coat, a focus 2-milimeters in diameter was visible (Fig. 1). It was formed by droplets of iatrogenic origin and surrounded by polynucleic histiocytes.

Bottom Line: The endoscopic injection of vesicoureteric orifices with synthetic or natural materials is a widely recognized method of treating vesicoureteral reflux (VUR).The aim of this study is to present two cases of clinically significant complications following the use of dextranomer/hyaluronic acid copolymer, which led to the progression of the reflux degree, permanent infection of the urinary tract, and the necessity to perform surgical treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology in Zabrze of the Medical University of Silesia in Katowice, Poland.

ABSTRACT
The endoscopic injection of vesicoureteric orifices with synthetic or natural materials is a widely recognized method of treating vesicoureteral reflux (VUR). The aim of this study is to present two cases of clinically significant complications following the use of dextranomer/hyaluronic acid copolymer, which led to the progression of the reflux degree, permanent infection of the urinary tract, and the necessity to perform surgical treatment.

No MeSH data available.


Related in: MedlinePlus