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Radical and sparing surgical treatment of patients with upper urinary tract transitional cell carcinomas (UUT -TCC) - preliminary results.

Jabłonowski Z, Kędzierski R, Sosnowski M - Cent European J Urol (2011)

Bottom Line: The aim of the study is to assess the results of treatment in patients with upper urinary tract transitional cell carcinomas (UUT-TCC).Then, the instituted treatment and its results were analyzed.Patients treated for urinary bladder carcinomas require regular monitoring of the upper urinary tract.

View Article: PubMed Central - PubMed

Affiliation: 1 Department of Urology, Medical University of Łódź, Poland.

ABSTRACT

Introduction: Tumors originating from transitional epithelium of the renal pelvis and ureter are infrequent. Their course is asymptomatic at early stages of the disease, and diagnosis and institution of appropriate treatment delayed. The aim of the study is to assess the results of treatment in patients with upper urinary tract transitional cell carcinomas (UUT-TCC).

Material and methods: Fifteen patients treated in 2005-2010 for UUT-TCC were qualified for the retrospective study. Clinical symptoms, diagnostic methods, tumor location, clinical stage and histopathological characteristics of the tumors were assessed. Then, the instituted treatment and its results were analyzed.

Results: The average follow-up period was 51 month (range 6-65), UUT-TCC accounted for 6.7% of renal tumors treated. Concurrent treated vesical tumors were observed in 4 (26.7%) patients. Primary UUT-TCC was diagnosed in 10 (66.7%) patients. Radical surgery was performed in 10 (66.7%) patients, whereas 5 (33.3%) underwent sparing operations. Macroscopic hematuria was the predominant clinical symptom. In most cases T2-T3 clinical stage (60.0%) and high-grade (66.7%) were observed. Development of an upper urinary tract tumor after treatment of a vesical tumor was noted in 4 (26.7%) patients. During the follow-up period, urinary bladder carcinomas were diagnosed in 5 (33.3%) patients with primary upper urinary tract tumors.

Conclusions: Nephroureterectomy remains the standard treatment for UUT-TCC. Organ-sparing surgery is possible in selected patients with low clinical stage and low grade tumors. Patients treated for urinary bladder carcinomas require regular monitoring of the upper urinary tract.

No MeSH data available.


Related in: MedlinePlus

Same patient-CT: left renal pelvis tumor.
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Figure 0002: Same patient-CT: left renal pelvis tumor.

Mentions: The decision concerning radical or organ-sparing management was based on the overall presentation of the disease (Figs. 1 & 2). Open nephroureterectomy (O-NFU) was performed in 10/15 patients (66.7%), whereas 5/15 patients (33.3%) underwent organ-sparing treatment (Figs. 3, 4). Organ-sparing surgery involved partial resection of the ureter with the tumor – in three patients (20.0%), partial resection of the solitary kidney together with the tumor of the renal pelvis in one female patient (6.7%) and partial bilateral ureterectomy including the tumor in another female (6.7%) (Fig. 5).


Radical and sparing surgical treatment of patients with upper urinary tract transitional cell carcinomas (UUT -TCC) - preliminary results.

Jabłonowski Z, Kędzierski R, Sosnowski M - Cent European J Urol (2011)

Same patient-CT: left renal pelvis tumor.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921709&req=5

Figure 0002: Same patient-CT: left renal pelvis tumor.
Mentions: The decision concerning radical or organ-sparing management was based on the overall presentation of the disease (Figs. 1 & 2). Open nephroureterectomy (O-NFU) was performed in 10/15 patients (66.7%), whereas 5/15 patients (33.3%) underwent organ-sparing treatment (Figs. 3, 4). Organ-sparing surgery involved partial resection of the ureter with the tumor – in three patients (20.0%), partial resection of the solitary kidney together with the tumor of the renal pelvis in one female patient (6.7%) and partial bilateral ureterectomy including the tumor in another female (6.7%) (Fig. 5).

Bottom Line: The aim of the study is to assess the results of treatment in patients with upper urinary tract transitional cell carcinomas (UUT-TCC).Then, the instituted treatment and its results were analyzed.Patients treated for urinary bladder carcinomas require regular monitoring of the upper urinary tract.

View Article: PubMed Central - PubMed

Affiliation: 1 Department of Urology, Medical University of Łódź, Poland.

ABSTRACT

Introduction: Tumors originating from transitional epithelium of the renal pelvis and ureter are infrequent. Their course is asymptomatic at early stages of the disease, and diagnosis and institution of appropriate treatment delayed. The aim of the study is to assess the results of treatment in patients with upper urinary tract transitional cell carcinomas (UUT-TCC).

Material and methods: Fifteen patients treated in 2005-2010 for UUT-TCC were qualified for the retrospective study. Clinical symptoms, diagnostic methods, tumor location, clinical stage and histopathological characteristics of the tumors were assessed. Then, the instituted treatment and its results were analyzed.

Results: The average follow-up period was 51 month (range 6-65), UUT-TCC accounted for 6.7% of renal tumors treated. Concurrent treated vesical tumors were observed in 4 (26.7%) patients. Primary UUT-TCC was diagnosed in 10 (66.7%) patients. Radical surgery was performed in 10 (66.7%) patients, whereas 5 (33.3%) underwent sparing operations. Macroscopic hematuria was the predominant clinical symptom. In most cases T2-T3 clinical stage (60.0%) and high-grade (66.7%) were observed. Development of an upper urinary tract tumor after treatment of a vesical tumor was noted in 4 (26.7%) patients. During the follow-up period, urinary bladder carcinomas were diagnosed in 5 (33.3%) patients with primary upper urinary tract tumors.

Conclusions: Nephroureterectomy remains the standard treatment for UUT-TCC. Organ-sparing surgery is possible in selected patients with low clinical stage and low grade tumors. Patients treated for urinary bladder carcinomas require regular monitoring of the upper urinary tract.

No MeSH data available.


Related in: MedlinePlus