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The SPI-1-like Type III secretion system: more roles than you think.

Egan F, Barret M, O'Gara F - Front Plant Sci (2014)

Bottom Line: Various phylogenetic families of the T3SS have been described, including the Salmonella Pathogenicity Island 1 family (SPI-1).The SPI-1 T3SS was initially associated with the virulence of enteric pathogens, but is actually found in a diverse array of bacterial species, where it can play roles in processes as different as symbiotic interactions with insects and colonization of plants.We review the multiple roles of the SPI-1 T3SS and discuss both how these discoveries are changing our perception of the SPI-1 family and what impacts this has on our understanding of the specialization of the T3SS in general.

View Article: PubMed Central - PubMed

Affiliation: BIOMERIT Research Centre, School of Microbiology, University College Cork Cork, Ireland.

ABSTRACT
The type III secretion system (T3SS) is a protein delivery system which is involved in a wide spectrum of interactions, from mutualism to pathogenesis, between Gram negative bacteria and various eukaryotes, including plants, fungi, protozoa and mammals. Various phylogenetic families of the T3SS have been described, including the Salmonella Pathogenicity Island 1 family (SPI-1). The SPI-1 T3SS was initially associated with the virulence of enteric pathogens, but is actually found in a diverse array of bacterial species, where it can play roles in processes as different as symbiotic interactions with insects and colonization of plants. We review the multiple roles of the SPI-1 T3SS and discuss both how these discoveries are changing our perception of the SPI-1 family and what impacts this has on our understanding of the specialization of the T3SS in general.

No MeSH data available.


Related in: MedlinePlus

Phylogenetic distribution of the SPI-1 T3SS. A distance tree (maximum likelihood based on the WAG model) was calculated from InvA homologs (COG4789) of the SPI-1 family. RscV (COG4789) from the Hrp1 T3SS of P. fluorescens F113 was used as an outgroup. Only aLRT support values greater than 0.75 (1000 replicates) are displayed.
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Figure 1: Phylogenetic distribution of the SPI-1 T3SS. A distance tree (maximum likelihood based on the WAG model) was calculated from InvA homologs (COG4789) of the SPI-1 family. RscV (COG4789) from the Hrp1 T3SS of P. fluorescens F113 was used as an outgroup. Only aLRT support values greater than 0.75 (1000 replicates) are displayed.

Mentions: The Salmonella pathogenicity island 1 (SPI-1) is a genetic locus which is involved in invasion of non-phagocytic cells by Salmonella spp. (Galan and Curtiss, 1989). Molecular analyses have revealed that the vast majority of the genes located in this region encoded a T3SS (Galan, 1996). Consequently the term SPI-1 was coined for this T3SS. Homologs of SPI-1 T3SS have been identified and found to be essential virulence determinants in other mammalian pathogens such as Chromobacterium, Escherichia, Shigella, and Yersinia species (Barinaga, 1996; Miki et al., 2010), thus confirming its role in animal/human pathogenesis. However, recent reports in the literature have highlighted the presence of SPI-1 T3SSs outside of mammalian pathogenic bacteria, such as Sodalis (Dale et al., 2005), Erwinia (Triplett et al., 2006), Xanthomonas (Alavi et al., 2008; Marguerettaz et al., 2011), Pantoea (Correa et al., 2012), and Pseudomonas species (Barret et al., 2013a; Redondo-Nieto et al., 2013). Concurrently, the rise in genome sequences is revealing that the SPI-1 T3SS is found in a multitude of other bacterial strains (Figure 1).


The SPI-1-like Type III secretion system: more roles than you think.

Egan F, Barret M, O'Gara F - Front Plant Sci (2014)

Phylogenetic distribution of the SPI-1 T3SS. A distance tree (maximum likelihood based on the WAG model) was calculated from InvA homologs (COG4789) of the SPI-1 family. RscV (COG4789) from the Hrp1 T3SS of P. fluorescens F113 was used as an outgroup. Only aLRT support values greater than 0.75 (1000 replicates) are displayed.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921676&req=5

Figure 1: Phylogenetic distribution of the SPI-1 T3SS. A distance tree (maximum likelihood based on the WAG model) was calculated from InvA homologs (COG4789) of the SPI-1 family. RscV (COG4789) from the Hrp1 T3SS of P. fluorescens F113 was used as an outgroup. Only aLRT support values greater than 0.75 (1000 replicates) are displayed.
Mentions: The Salmonella pathogenicity island 1 (SPI-1) is a genetic locus which is involved in invasion of non-phagocytic cells by Salmonella spp. (Galan and Curtiss, 1989). Molecular analyses have revealed that the vast majority of the genes located in this region encoded a T3SS (Galan, 1996). Consequently the term SPI-1 was coined for this T3SS. Homologs of SPI-1 T3SS have been identified and found to be essential virulence determinants in other mammalian pathogens such as Chromobacterium, Escherichia, Shigella, and Yersinia species (Barinaga, 1996; Miki et al., 2010), thus confirming its role in animal/human pathogenesis. However, recent reports in the literature have highlighted the presence of SPI-1 T3SSs outside of mammalian pathogenic bacteria, such as Sodalis (Dale et al., 2005), Erwinia (Triplett et al., 2006), Xanthomonas (Alavi et al., 2008; Marguerettaz et al., 2011), Pantoea (Correa et al., 2012), and Pseudomonas species (Barret et al., 2013a; Redondo-Nieto et al., 2013). Concurrently, the rise in genome sequences is revealing that the SPI-1 T3SS is found in a multitude of other bacterial strains (Figure 1).

Bottom Line: Various phylogenetic families of the T3SS have been described, including the Salmonella Pathogenicity Island 1 family (SPI-1).The SPI-1 T3SS was initially associated with the virulence of enteric pathogens, but is actually found in a diverse array of bacterial species, where it can play roles in processes as different as symbiotic interactions with insects and colonization of plants.We review the multiple roles of the SPI-1 T3SS and discuss both how these discoveries are changing our perception of the SPI-1 family and what impacts this has on our understanding of the specialization of the T3SS in general.

View Article: PubMed Central - PubMed

Affiliation: BIOMERIT Research Centre, School of Microbiology, University College Cork Cork, Ireland.

ABSTRACT
The type III secretion system (T3SS) is a protein delivery system which is involved in a wide spectrum of interactions, from mutualism to pathogenesis, between Gram negative bacteria and various eukaryotes, including plants, fungi, protozoa and mammals. Various phylogenetic families of the T3SS have been described, including the Salmonella Pathogenicity Island 1 family (SPI-1). The SPI-1 T3SS was initially associated with the virulence of enteric pathogens, but is actually found in a diverse array of bacterial species, where it can play roles in processes as different as symbiotic interactions with insects and colonization of plants. We review the multiple roles of the SPI-1 T3SS and discuss both how these discoveries are changing our perception of the SPI-1 family and what impacts this has on our understanding of the specialization of the T3SS in general.

No MeSH data available.


Related in: MedlinePlus