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Adverse effects of high doses of intravenous alpha lipoic Acid on liver mitochondria.

Vigil M, Berkson BM, Garcia AP - Glob Adv Health Med (2014)

Bottom Line: Therefore, it is necessary for the production of energy for aerobic organisms.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, New Mexico State University, Las Cruces (Dr Vigil).

ABSTRACT
Alpha lipoic acid (ALA, thioctic acid), among other actions, is an essential coenzyme in the conversion of pyruvate to acetyl co-enzyme A. Therefore, it is necessary for the production of energy for aerobic organisms. Scientists have found that it can be used medically to help regenerate liver tissue, reverse the complications of diabetes mellitus, slow or stop the growth of cancer cells, and chelate heavy metals, among other actions. In this article, the authors describe the cellular mitochondrial damage from excessively high doses of this beneficial agent.

No MeSH data available.


Related in: MedlinePlus

Primate mitochondria after exposure to extremely high doses of intravenous alpha lipoic acid. Note gross swelling and damage to cristae.
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Figure 2: Primate mitochondria after exposure to extremely high doses of intravenous alpha lipoic acid. Note gross swelling and damage to cristae.

Mentions: Mitochondria from animals that had received excessively high doses of ALA became extremely edematous and demonstrated a disruption of all of the crucial membranes (Figure 2). These mitochondria did not exhibit the regular double membrane wall structure but showed a coalescence of these structures with a deliquescence of other structures, thus exhibiting a complete disruption of normal ultrastructure.


Adverse effects of high doses of intravenous alpha lipoic Acid on liver mitochondria.

Vigil M, Berkson BM, Garcia AP - Glob Adv Health Med (2014)

Primate mitochondria after exposure to extremely high doses of intravenous alpha lipoic acid. Note gross swelling and damage to cristae.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3921613&req=5

Figure 2: Primate mitochondria after exposure to extremely high doses of intravenous alpha lipoic acid. Note gross swelling and damage to cristae.
Mentions: Mitochondria from animals that had received excessively high doses of ALA became extremely edematous and demonstrated a disruption of all of the crucial membranes (Figure 2). These mitochondria did not exhibit the regular double membrane wall structure but showed a coalescence of these structures with a deliquescence of other structures, thus exhibiting a complete disruption of normal ultrastructure.

Bottom Line: Therefore, it is necessary for the production of energy for aerobic organisms.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, New Mexico State University, Las Cruces (Dr Vigil).

ABSTRACT
Alpha lipoic acid (ALA, thioctic acid), among other actions, is an essential coenzyme in the conversion of pyruvate to acetyl co-enzyme A. Therefore, it is necessary for the production of energy for aerobic organisms. Scientists have found that it can be used medically to help regenerate liver tissue, reverse the complications of diabetes mellitus, slow or stop the growth of cancer cells, and chelate heavy metals, among other actions. In this article, the authors describe the cellular mitochondrial damage from excessively high doses of this beneficial agent.

No MeSH data available.


Related in: MedlinePlus