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Adverse effects of high doses of intravenous alpha lipoic Acid on liver mitochondria.

Vigil M, Berkson BM, Garcia AP - Glob Adv Health Med (2014)

Bottom Line: Therefore, it is necessary for the production of energy for aerobic organisms.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, New Mexico State University, Las Cruces (Dr Vigil).

ABSTRACT
Alpha lipoic acid (ALA, thioctic acid), among other actions, is an essential coenzyme in the conversion of pyruvate to acetyl co-enzyme A. Therefore, it is necessary for the production of energy for aerobic organisms. Scientists have found that it can be used medically to help regenerate liver tissue, reverse the complications of diabetes mellitus, slow or stop the growth of cancer cells, and chelate heavy metals, among other actions. In this article, the authors describe the cellular mitochondrial damage from excessively high doses of this beneficial agent.

No MeSH data available.


Related in: MedlinePlus

Healthy primate mitochondria. Note intact membranes and cristae.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3921613&req=5

Figure 1: Healthy primate mitochondria. Note intact membranes and cristae.

Mentions: Typical rhesus monkey liver tissue demonstrates normally appearing mitochondria with numerous intact christae and other healthy membranes (Figure 1). The normal hepatocyte mitochondrion exhibits a double membrane wall with an infolding of the inner wall to form an extensive inner surface of christae on the surface of which ATP is generated.


Adverse effects of high doses of intravenous alpha lipoic Acid on liver mitochondria.

Vigil M, Berkson BM, Garcia AP - Glob Adv Health Med (2014)

Healthy primate mitochondria. Note intact membranes and cristae.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3921613&req=5

Figure 1: Healthy primate mitochondria. Note intact membranes and cristae.
Mentions: Typical rhesus monkey liver tissue demonstrates normally appearing mitochondria with numerous intact christae and other healthy membranes (Figure 1). The normal hepatocyte mitochondrion exhibits a double membrane wall with an infolding of the inner wall to form an extensive inner surface of christae on the surface of which ATP is generated.

Bottom Line: Therefore, it is necessary for the production of energy for aerobic organisms.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, New Mexico State University, Las Cruces (Dr Vigil).

ABSTRACT
Alpha lipoic acid (ALA, thioctic acid), among other actions, is an essential coenzyme in the conversion of pyruvate to acetyl co-enzyme A. Therefore, it is necessary for the production of energy for aerobic organisms. Scientists have found that it can be used medically to help regenerate liver tissue, reverse the complications of diabetes mellitus, slow or stop the growth of cancer cells, and chelate heavy metals, among other actions. In this article, the authors describe the cellular mitochondrial damage from excessively high doses of this beneficial agent.

No MeSH data available.


Related in: MedlinePlus