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Integrative nanomedicine: treating cancer with nanoscale natural products.

Bell IR, Sarter B, Koithan M, Banerji P, Banerji P, Jain S, Ives J - Glob Adv Health Med (2014)

Bottom Line: The result can be a cascade of modulatory biological events with antiproliferative and pro-apoptotic effects.Past research on antineoplastic effects of nano forms of botanical extracts such as Phytolacca, Gelsemium, Hydrastis, Thuja, and Ruta as well as on homeopathic remedy potencies made from the same types of source materials suggests other important overlaps.The replicated finding of silica, silicon, and nano-silica release from agitation of liquids in glassware adds a proven nonspecific activator and amplifier of immunological effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Family and Community Medicine, The University of Arizona College of Medicine, Tucson (Dr Bell), United States.

ABSTRACT
Finding safer and more effective treatments for specific cancers remains a significant challenge for integrative clinicians and researchers worldwide. One emerging strategy is the use of nanostructured forms of drugs, vaccines, traditional animal venoms, herbs, and nutraceutical agents in cancer treatment. The recent discovery of nanoparticles in traditional homeopathic medicines adds another point of convergence between modern nanomedicine and alternative interventional strategies. A way in which homeopathic remedies could initiate anticancer effects includes cell-to-cell signaling actions of both exogenous and endogenous (exosome) nanoparticles. The result can be a cascade of modulatory biological events with antiproliferative and pro-apoptotic effects. The Banerji Protocols reflect a multigenerational clinical system developed by homeopathic physicians in India who have treated thousands of patients with cancer. A number of homeopathic remedy sources from the Banerji Protocols (eg, Calcarea phosphorica; Carcinosin-tumor-derived breast cancer tissue prepared homeopathically) overlap those already under study in nonhomeopathic nanoparticle and nanovesicle tumor exosome cancer vaccine research. Past research on antineoplastic effects of nano forms of botanical extracts such as Phytolacca, Gelsemium, Hydrastis, Thuja, and Ruta as well as on homeopathic remedy potencies made from the same types of source materials suggests other important overlaps. The replicated finding of silica, silicon, and nano-silica release from agitation of liquids in glassware adds a proven nonspecific activator and amplifier of immunological effects. Taken together, the nanoparticulate research data and the Banerji Protocols for homeopathic remedies in cancer suggest a way forward for generating advances in cancer treatment with natural product-derived nanomedicines.

No MeSH data available.


Related in: MedlinePlus

Silica nanoparticles amplify apoptotic effects of biologically active natural agent. Data from five different experiments are expressed as the mean percentage of apoptotic cells ± SEM for the control (open bars), NP-treated (gray bars), WEV-treated (closed black bars), and WEV+NP–treated (hatched bars). *P < .05, WEV-treated vs NP; #P < .05, WEV+NP-treated vs NP; +P < .05, WEV+NP-treated vs WEV-treated cells. WEV = venom of Walterinnesia aegyptia snake; NP = silica nanoparticles. MDA-MB-231 and MCF-7 are human breast cancer cells; MCF-10 are normal breast epithelial cells. Reprinted with permission from publisher S. Karger AG, Basel, from reference.103
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Related In: Results  -  Collection


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Figure 3: Silica nanoparticles amplify apoptotic effects of biologically active natural agent. Data from five different experiments are expressed as the mean percentage of apoptotic cells ± SEM for the control (open bars), NP-treated (gray bars), WEV-treated (closed black bars), and WEV+NP–treated (hatched bars). *P < .05, WEV-treated vs NP; #P < .05, WEV+NP-treated vs NP; +P < .05, WEV+NP-treated vs WEV-treated cells. WEV = venom of Walterinnesia aegyptia snake; NP = silica nanoparticles. MDA-MB-231 and MCF-7 are human breast cancer cells; MCF-10 are normal breast epithelial cells. Reprinted with permission from publisher S. Karger AG, Basel, from reference.103

Mentions: What would the presence of nanosilica add to natural product cancer treatment? Several nonhomeopathic studies of the effects of a traditional Middle Eastern animal venom–derived treatment on cancer cells begin to answer that question. The addition of modern manufactured silica nanoparticles to a snake venom–derived medicine significantly enhanced the apoptotic and growth arrest effects of the treatment on breast cancer cells (Figure 3).103 The same type of combination treatment (snake venom with silica nanoparticles) also improved anticancer effects against malignant myeloma cells104 and human prostate cancer cells.105 Like certain types of nanoparticles,106-108 some homeopathic remedies with antineoplastic properties exhibit the ability to attack cancer cells while leaving healthy cells intact.109,110


Integrative nanomedicine: treating cancer with nanoscale natural products.

Bell IR, Sarter B, Koithan M, Banerji P, Banerji P, Jain S, Ives J - Glob Adv Health Med (2014)

Silica nanoparticles amplify apoptotic effects of biologically active natural agent. Data from five different experiments are expressed as the mean percentage of apoptotic cells ± SEM for the control (open bars), NP-treated (gray bars), WEV-treated (closed black bars), and WEV+NP–treated (hatched bars). *P < .05, WEV-treated vs NP; #P < .05, WEV+NP-treated vs NP; +P < .05, WEV+NP-treated vs WEV-treated cells. WEV = venom of Walterinnesia aegyptia snake; NP = silica nanoparticles. MDA-MB-231 and MCF-7 are human breast cancer cells; MCF-10 are normal breast epithelial cells. Reprinted with permission from publisher S. Karger AG, Basel, from reference.103
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3921611&req=5

Figure 3: Silica nanoparticles amplify apoptotic effects of biologically active natural agent. Data from five different experiments are expressed as the mean percentage of apoptotic cells ± SEM for the control (open bars), NP-treated (gray bars), WEV-treated (closed black bars), and WEV+NP–treated (hatched bars). *P < .05, WEV-treated vs NP; #P < .05, WEV+NP-treated vs NP; +P < .05, WEV+NP-treated vs WEV-treated cells. WEV = venom of Walterinnesia aegyptia snake; NP = silica nanoparticles. MDA-MB-231 and MCF-7 are human breast cancer cells; MCF-10 are normal breast epithelial cells. Reprinted with permission from publisher S. Karger AG, Basel, from reference.103
Mentions: What would the presence of nanosilica add to natural product cancer treatment? Several nonhomeopathic studies of the effects of a traditional Middle Eastern animal venom–derived treatment on cancer cells begin to answer that question. The addition of modern manufactured silica nanoparticles to a snake venom–derived medicine significantly enhanced the apoptotic and growth arrest effects of the treatment on breast cancer cells (Figure 3).103 The same type of combination treatment (snake venom with silica nanoparticles) also improved anticancer effects against malignant myeloma cells104 and human prostate cancer cells.105 Like certain types of nanoparticles,106-108 some homeopathic remedies with antineoplastic properties exhibit the ability to attack cancer cells while leaving healthy cells intact.109,110

Bottom Line: The result can be a cascade of modulatory biological events with antiproliferative and pro-apoptotic effects.Past research on antineoplastic effects of nano forms of botanical extracts such as Phytolacca, Gelsemium, Hydrastis, Thuja, and Ruta as well as on homeopathic remedy potencies made from the same types of source materials suggests other important overlaps.The replicated finding of silica, silicon, and nano-silica release from agitation of liquids in glassware adds a proven nonspecific activator and amplifier of immunological effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Family and Community Medicine, The University of Arizona College of Medicine, Tucson (Dr Bell), United States.

ABSTRACT
Finding safer and more effective treatments for specific cancers remains a significant challenge for integrative clinicians and researchers worldwide. One emerging strategy is the use of nanostructured forms of drugs, vaccines, traditional animal venoms, herbs, and nutraceutical agents in cancer treatment. The recent discovery of nanoparticles in traditional homeopathic medicines adds another point of convergence between modern nanomedicine and alternative interventional strategies. A way in which homeopathic remedies could initiate anticancer effects includes cell-to-cell signaling actions of both exogenous and endogenous (exosome) nanoparticles. The result can be a cascade of modulatory biological events with antiproliferative and pro-apoptotic effects. The Banerji Protocols reflect a multigenerational clinical system developed by homeopathic physicians in India who have treated thousands of patients with cancer. A number of homeopathic remedy sources from the Banerji Protocols (eg, Calcarea phosphorica; Carcinosin-tumor-derived breast cancer tissue prepared homeopathically) overlap those already under study in nonhomeopathic nanoparticle and nanovesicle tumor exosome cancer vaccine research. Past research on antineoplastic effects of nano forms of botanical extracts such as Phytolacca, Gelsemium, Hydrastis, Thuja, and Ruta as well as on homeopathic remedy potencies made from the same types of source materials suggests other important overlaps. The replicated finding of silica, silicon, and nano-silica release from agitation of liquids in glassware adds a proven nonspecific activator and amplifier of immunological effects. Taken together, the nanoparticulate research data and the Banerji Protocols for homeopathic remedies in cancer suggest a way forward for generating advances in cancer treatment with natural product-derived nanomedicines.

No MeSH data available.


Related in: MedlinePlus