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The Interplay between Daptomycin and the Immune System.

Kelesidis T - Front Immunol (2014)

Bottom Line: However, the possible immunomodulatory effects of daptomycin remain unknown.Preliminary studies suggest that daptomycin may have minimal effects on cytokine production and may have synergistic immunomodulatory effects in combination with other immunomodulators.This review focuses on the hypothesis that daptomycin may also have immunomodulatory effects but further studies are needed to investigate this hypothesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine, University of California , Los Angeles, CA , USA.

ABSTRACT
Antibiotics may have bacteriostatic or bactericidal effects but may also cause immunomodulation. Lipopeptides are known immunomodulators that interact with pattern recognition receptors such as Toll-like receptors in antigen presenting cells. Daptomycin is a novel lipopeptide antibiotic with a lipid moiety and unique structure that in the presence of divalent ions may directly interact with lipid membrane phospholipids, the major component of lipid membranes in immune cells. Daptomycin may also penetrate immune cells including neutrophils and macrophages. However, the possible immunomodulatory effects of daptomycin remain unknown. Understanding these effects is important to determine whether this agent can provide protection against infectious challenge through multiple mechanisms. Preliminary studies suggest that daptomycin may have minimal effects on cytokine production and may have synergistic immunomodulatory effects in combination with other immunomodulators. This review focuses on the hypothesis that daptomycin may also have immunomodulatory effects but further studies are needed to investigate this hypothesis.

No MeSH data available.


Related in: MedlinePlus

Possible immunomodulation related to daptomycin. Immunological effects of lipopeptides have previously been described but the interplay of daptomycin with immunity has been minimally studied.
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Figure 2: Possible immunomodulation related to daptomycin. Immunological effects of lipopeptides have previously been described but the interplay of daptomycin with immunity has been minimally studied.

Mentions: Antibiotics may have bactericidal effects but may also cause immunomodulation. Lipopeptides are known adjuvants and immunomodulators that interact with PRRs such as TLRs in APCs. Daptomycin is a novel lipopeptide antibiotic that is largely water-soluble with a low volume of distribution but its lipid moiety and unique structure in the presence of divalent ions contribute to direct interaction with lipid membrane phospholipids. Although daptomycin preferentially interacts with acidic phospholipids that are present in the lipid membrane of gram-positive pathogens, it may also directly interact with human surfactant and PC, the major component of lipid membranes in immune cells. Daptomycin may also penetrate immune cells including neutrophils and macrophages. However, the possible immunomodulatory effects of daptomycin remain unknown (Figure 2). Preliminary studies suggest that daptomycin may have minimal effects on cytokine production and may have synergistic immunomodulatory effects (such as effects on NK cell activity) in combination with other immunomodulators. Understanding whether daptomycin may be an immunomodulatory agent is important to optimize the clinical use of this agent, especially in the era of increased antimicrobial resistance. Further studies are needed to investigate the interplay between daptomycin and immunity.


The Interplay between Daptomycin and the Immune System.

Kelesidis T - Front Immunol (2014)

Possible immunomodulation related to daptomycin. Immunological effects of lipopeptides have previously been described but the interplay of daptomycin with immunity has been minimally studied.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921582&req=5

Figure 2: Possible immunomodulation related to daptomycin. Immunological effects of lipopeptides have previously been described but the interplay of daptomycin with immunity has been minimally studied.
Mentions: Antibiotics may have bactericidal effects but may also cause immunomodulation. Lipopeptides are known adjuvants and immunomodulators that interact with PRRs such as TLRs in APCs. Daptomycin is a novel lipopeptide antibiotic that is largely water-soluble with a low volume of distribution but its lipid moiety and unique structure in the presence of divalent ions contribute to direct interaction with lipid membrane phospholipids. Although daptomycin preferentially interacts with acidic phospholipids that are present in the lipid membrane of gram-positive pathogens, it may also directly interact with human surfactant and PC, the major component of lipid membranes in immune cells. Daptomycin may also penetrate immune cells including neutrophils and macrophages. However, the possible immunomodulatory effects of daptomycin remain unknown (Figure 2). Preliminary studies suggest that daptomycin may have minimal effects on cytokine production and may have synergistic immunomodulatory effects (such as effects on NK cell activity) in combination with other immunomodulators. Understanding whether daptomycin may be an immunomodulatory agent is important to optimize the clinical use of this agent, especially in the era of increased antimicrobial resistance. Further studies are needed to investigate the interplay between daptomycin and immunity.

Bottom Line: However, the possible immunomodulatory effects of daptomycin remain unknown.Preliminary studies suggest that daptomycin may have minimal effects on cytokine production and may have synergistic immunomodulatory effects in combination with other immunomodulators.This review focuses on the hypothesis that daptomycin may also have immunomodulatory effects but further studies are needed to investigate this hypothesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine, University of California , Los Angeles, CA , USA.

ABSTRACT
Antibiotics may have bacteriostatic or bactericidal effects but may also cause immunomodulation. Lipopeptides are known immunomodulators that interact with pattern recognition receptors such as Toll-like receptors in antigen presenting cells. Daptomycin is a novel lipopeptide antibiotic with a lipid moiety and unique structure that in the presence of divalent ions may directly interact with lipid membrane phospholipids, the major component of lipid membranes in immune cells. Daptomycin may also penetrate immune cells including neutrophils and macrophages. However, the possible immunomodulatory effects of daptomycin remain unknown. Understanding these effects is important to determine whether this agent can provide protection against infectious challenge through multiple mechanisms. Preliminary studies suggest that daptomycin may have minimal effects on cytokine production and may have synergistic immunomodulatory effects in combination with other immunomodulators. This review focuses on the hypothesis that daptomycin may also have immunomodulatory effects but further studies are needed to investigate this hypothesis.

No MeSH data available.


Related in: MedlinePlus