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Wheal and flare reactions in skin prick tests of patients treated with montelukast alone or in combination with antihistamines.

Ciebiada MG, Barylski M, Ciebiada M - Inflamm. Res. (2013)

Bottom Line: Monotherapy with montelukast did not change the size of the wheal for either histamine or for house dust mites, in either arm of the study, but significantly reduced the size of flare for histamine in arm A.Addition of montelukast to antihistamine did not exceed efficacy of monotherapy with antihistamine in both arms of the study.Since the size of wheal determines the results of SPT, montelukast, even taken for a long time, does not have to be discarded prior to the tests.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine and Diabetology, Medical University of Lodz, Lodz, Poland.

ABSTRACT

Background: Because antileukotrienes may inhibit inflammation, it is plausible that montelukast administered for a long time could suppress skin wheal and flare reaction, and thus, it should be discarded prior to the tests. This study assessed the effect of long-lasting treatment with montelukast alone or in combination with antihistamines on wheal and flare in skin pricks tests (SPT) in patients sensitized to perennial allergens.

Methods: We conducted a 32-week, double-blind, placebo-controlled, cross-over and randomized trial that implicated two arms: arm A, 20 patients received levocetirizine, montelukast with or without levocetirizine or placebo; arm B, 20 patients received desloratadine, montelukast with or without desloratadine or placebo. All treatment periods lasted 6 weeks and were separated by 2-week washouts. At baseline and on the last day of each treatment period, SPT were performed in all participants.

Results: Both levocetirizine and desloratadine in monotherapy, or in combination with montelukast, were effective in reducing wheal and flare in SPT. Monotherapy with montelukast did not change the size of the wheal for either histamine or for house dust mites, in either arm of the study, but significantly reduced the size of flare for histamine in arm A. Addition of montelukast to antihistamine did not exceed efficacy of monotherapy with antihistamine in both arms of the study.

Conclusions: Since the size of wheal determines the results of SPT, montelukast, even taken for a long time, does not have to be discarded prior to the tests.

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Mean diameter of wheal for Dermatophagoides pteronyssinus in patients treated in montelukast/levocetirizine arm (graph A), and montelukast/desloratadine arm (graph B). Data are expressed as mean ± SEM; m + l, montelukast with levocetirizine; m + d, montelukast with desloratadine; **p < 0.01
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Fig2: Mean diameter of wheal for Dermatophagoides pteronyssinus in patients treated in montelukast/levocetirizine arm (graph A), and montelukast/desloratadine arm (graph B). Data are expressed as mean ± SEM; m + l, montelukast with levocetirizine; m + d, montelukast with desloratadine; **p < 0.01

Mentions: Generally, the mean size of the wheal and flare was the biggest at baseline. The placebo did not affect the size of skin reactions both to histamine and HDM in patients evaluated in the arm A and B (Table 2; Figs. 1, 2, 3).Table 2


Wheal and flare reactions in skin prick tests of patients treated with montelukast alone or in combination with antihistamines.

Ciebiada MG, Barylski M, Ciebiada M - Inflamm. Res. (2013)

Mean diameter of wheal for Dermatophagoides pteronyssinus in patients treated in montelukast/levocetirizine arm (graph A), and montelukast/desloratadine arm (graph B). Data are expressed as mean ± SEM; m + l, montelukast with levocetirizine; m + d, montelukast with desloratadine; **p < 0.01
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3921455&req=5

Fig2: Mean diameter of wheal for Dermatophagoides pteronyssinus in patients treated in montelukast/levocetirizine arm (graph A), and montelukast/desloratadine arm (graph B). Data are expressed as mean ± SEM; m + l, montelukast with levocetirizine; m + d, montelukast with desloratadine; **p < 0.01
Mentions: Generally, the mean size of the wheal and flare was the biggest at baseline. The placebo did not affect the size of skin reactions both to histamine and HDM in patients evaluated in the arm A and B (Table 2; Figs. 1, 2, 3).Table 2

Bottom Line: Monotherapy with montelukast did not change the size of the wheal for either histamine or for house dust mites, in either arm of the study, but significantly reduced the size of flare for histamine in arm A.Addition of montelukast to antihistamine did not exceed efficacy of monotherapy with antihistamine in both arms of the study.Since the size of wheal determines the results of SPT, montelukast, even taken for a long time, does not have to be discarded prior to the tests.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine and Diabetology, Medical University of Lodz, Lodz, Poland.

ABSTRACT

Background: Because antileukotrienes may inhibit inflammation, it is plausible that montelukast administered for a long time could suppress skin wheal and flare reaction, and thus, it should be discarded prior to the tests. This study assessed the effect of long-lasting treatment with montelukast alone or in combination with antihistamines on wheal and flare in skin pricks tests (SPT) in patients sensitized to perennial allergens.

Methods: We conducted a 32-week, double-blind, placebo-controlled, cross-over and randomized trial that implicated two arms: arm A, 20 patients received levocetirizine, montelukast with or without levocetirizine or placebo; arm B, 20 patients received desloratadine, montelukast with or without desloratadine or placebo. All treatment periods lasted 6 weeks and were separated by 2-week washouts. At baseline and on the last day of each treatment period, SPT were performed in all participants.

Results: Both levocetirizine and desloratadine in monotherapy, or in combination with montelukast, were effective in reducing wheal and flare in SPT. Monotherapy with montelukast did not change the size of the wheal for either histamine or for house dust mites, in either arm of the study, but significantly reduced the size of flare for histamine in arm A. Addition of montelukast to antihistamine did not exceed efficacy of monotherapy with antihistamine in both arms of the study.

Conclusions: Since the size of wheal determines the results of SPT, montelukast, even taken for a long time, does not have to be discarded prior to the tests.

Show MeSH
Related in: MedlinePlus