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Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits.

Azevedo AS, Sá MJ, Fook MV, Neto PI, Sousa OB, Azevedo SS, Teixeira MW, Costa FS, Araújo AL - J Mater Sci Mater Med (2013)

Bottom Line: We performed two osteotomies in each tibia.Tomographic evaluation showed no statistically significant difference among groups; however radiopacity was higher in the treated groups.Comparative descriptive histological evaluation found that treatment groups stimulated a more pronounced tissue repair reaction and accelerated bone repair.

View Article: PubMed Central - PubMed

Affiliation: Unidade acadêmica de Medicina Veterinária (UAMV), Centro de Saúde e Tecnologia Rural (CSTR), Universidade Federal de Campina Grande (UFCG), Av. Universitária s/n, Bairro Santa Cecília, Patos, PB, 58700-970, Brazil, adilio_vet@yahoo.com.br.

ABSTRACT
The aim of this research was to evaluate the process of bone regeneration in rabbits, using chitosan and beta-tricalcium phosphate (β-TCP) independently and in combination. A total of 12 New Zealand rabbits of both sexes, with average weight of 3.0 ± 0.57 kg were used. Animals were randomly divided into two experimental time points, with six animals euthanized 45 days after surgery and six euthanized 90 days after surgery. We performed two osteotomies in each tibia. The left tibia was used for the chitosan (QUI) and control groups, and the right tibia was used for the β-TCP alone and in combination with chitosan (QUI+TCP) groups. Tomographic evaluation showed no statistically significant difference among groups; however radiopacity was higher in the treated groups. Comparative descriptive histological evaluation found that treatment groups stimulated a more pronounced tissue repair reaction and accelerated bone repair. Morphometric analysis showed that treatment groups presented statistically higher bone formation compared with the control group.

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Related in: MedlinePlus

Mean and standard deviation of radiodensity in Hounsfield units (HU) at 45 and 90 days. Osteotomized area received the treatments; C control, QUI chitosan only, QUI+TCP chitosan in combination with tricalcium phosphate (TCP), TCP TCP only
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Fig1: Mean and standard deviation of radiodensity in Hounsfield units (HU) at 45 and 90 days. Osteotomized area received the treatments; C control, QUI chitosan only, QUI+TCP chitosan in combination with tricalcium phosphate (TCP), TCP TCP only

Mentions: CT evaluation found no statistical difference between groups or between times. However, as highlighted in Fig. 1, the mean HU values for the groups, TCP+QUI, QUI and TCP, were higher in the experimental time points studied compared with group C.Fig. 1


Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits.

Azevedo AS, Sá MJ, Fook MV, Neto PI, Sousa OB, Azevedo SS, Teixeira MW, Costa FS, Araújo AL - J Mater Sci Mater Med (2013)

Mean and standard deviation of radiodensity in Hounsfield units (HU) at 45 and 90 days. Osteotomized area received the treatments; C control, QUI chitosan only, QUI+TCP chitosan in combination with tricalcium phosphate (TCP), TCP TCP only
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3921445&req=5

Fig1: Mean and standard deviation of radiodensity in Hounsfield units (HU) at 45 and 90 days. Osteotomized area received the treatments; C control, QUI chitosan only, QUI+TCP chitosan in combination with tricalcium phosphate (TCP), TCP TCP only
Mentions: CT evaluation found no statistical difference between groups or between times. However, as highlighted in Fig. 1, the mean HU values for the groups, TCP+QUI, QUI and TCP, were higher in the experimental time points studied compared with group C.Fig. 1

Bottom Line: We performed two osteotomies in each tibia.Tomographic evaluation showed no statistically significant difference among groups; however radiopacity was higher in the treated groups.Comparative descriptive histological evaluation found that treatment groups stimulated a more pronounced tissue repair reaction and accelerated bone repair.

View Article: PubMed Central - PubMed

Affiliation: Unidade acadêmica de Medicina Veterinária (UAMV), Centro de Saúde e Tecnologia Rural (CSTR), Universidade Federal de Campina Grande (UFCG), Av. Universitária s/n, Bairro Santa Cecília, Patos, PB, 58700-970, Brazil, adilio_vet@yahoo.com.br.

ABSTRACT
The aim of this research was to evaluate the process of bone regeneration in rabbits, using chitosan and beta-tricalcium phosphate (β-TCP) independently and in combination. A total of 12 New Zealand rabbits of both sexes, with average weight of 3.0 ± 0.57 kg were used. Animals were randomly divided into two experimental time points, with six animals euthanized 45 days after surgery and six euthanized 90 days after surgery. We performed two osteotomies in each tibia. The left tibia was used for the chitosan (QUI) and control groups, and the right tibia was used for the β-TCP alone and in combination with chitosan (QUI+TCP) groups. Tomographic evaluation showed no statistically significant difference among groups; however radiopacity was higher in the treated groups. Comparative descriptive histological evaluation found that treatment groups stimulated a more pronounced tissue repair reaction and accelerated bone repair. Morphometric analysis showed that treatment groups presented statistically higher bone formation compared with the control group.

Show MeSH
Related in: MedlinePlus