Limits...
Therapeutic advantages of treatment of high-dose curcumin in the ovariectomized rat.

Cho DC, Jung HS, Kim KT, Jeon Y, Sung JK, Hwang JH - J Korean Neurosurg Soc (2013)

Bottom Line: High-dose curcumin group showed significantly lower osteocalcin, alkaline phosphatase, and the telopeptide fragment of type I collagen C-terminus concentration at 4 and 8 weeks compared with the untreated OVX group as well as low-dose curcumin group.Only high-dose curcumin treated group had a significant increase of mechanical strength compared with the untreated OVX group (p=0.015).The present study results demonstrat that a high-dose curcumin has therapeutic advantages over a low-dose curcumin of an antiresorptive effect on bone remodeling and improving bone mechanical strength.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, School of Medicine, Kyungpook National University, Daegu, Korea.

ABSTRACT

Objective: Although curcumin has a protective effect on bone remodeling, appropriate therapeutic concentrations of curcumin are not well known as therapeutic drugs for osteoporosis. The purpose of this study was to compare the bone sparing effect of treatment of low-dose and high-dose curcumin after ovariectomy in rats.

Methods: Forty female Sprague-Dawley rats underwent either a sham operation (the sham group) or bilateral ovariectomy (OVX). The ovariectomized animals were randomly distributed among three groups; untreated OVX group, low-dose (10 mg/kg) curcumin administered group, and high-dose (50 mg/kg) curcumin group. At 4 and 8 weeks after surgery, serum biochemical markers of bone turnover were analyzed. Bone histomorphometric parameters of the 4th lumbar vertebrae were determined by micro-computed tomography (CT). In addition, mechanical strength was determined by a three-point bending test.

Results: High-dose curcumin group showed significantly lower osteocalcin, alkaline phosphatase, and the telopeptide fragment of type I collagen C-terminus concentration at 4 and 8 weeks compared with the untreated OVX group as well as low-dose curcumin group. In the analyses of micro-CT scans of 4th lumbar vertebrae, the high-dose curcumin treated group showed a significant increase in bone mineral densities (p=0.028) and cortical bone mineral densities (p=0.036) compared with the low-dose curcumin treated group. Only high-dose curcumin treated group had a significant increase of mechanical strength compared with the untreated OVX group (p=0.015).

Conclusion: The present study results demonstrat that a high-dose curcumin has therapeutic advantages over a low-dose curcumin of an antiresorptive effect on bone remodeling and improving bone mechanical strength.

No MeSH data available.


Related in: MedlinePlus

Graphs showing the serum levels of osteocalcin (A), alkaline phosphatase (ALP) (B), and type I collagen C-telopeptide (CTX-1) (C). Values are expressed as percentage of the serum levels of the sham group. *p<0.05 for the values of the low-dose or high-dose curcumin group compared with that of untreated ovariectomy (OVX) group, †p<0.05 for the values of the high-dose curcumin group compared with that of low-dose curcumin group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3921272&req=5

Figure 2: Graphs showing the serum levels of osteocalcin (A), alkaline phosphatase (ALP) (B), and type I collagen C-telopeptide (CTX-1) (C). Values are expressed as percentage of the serum levels of the sham group. *p<0.05 for the values of the low-dose or high-dose curcumin group compared with that of untreated ovariectomy (OVX) group, †p<0.05 for the values of the high-dose curcumin group compared with that of low-dose curcumin group.

Mentions: Fig. 2A, B show the serum levels of the bone formation biochemical markers, osteocalcin and ALP, and Fig. 2C shows the serum levels of CTX-1, which is a sensitive marker of bone resorption. Results have been expressed as percentage of the serum levels of the biochemical markers of the sham group.


Therapeutic advantages of treatment of high-dose curcumin in the ovariectomized rat.

Cho DC, Jung HS, Kim KT, Jeon Y, Sung JK, Hwang JH - J Korean Neurosurg Soc (2013)

Graphs showing the serum levels of osteocalcin (A), alkaline phosphatase (ALP) (B), and type I collagen C-telopeptide (CTX-1) (C). Values are expressed as percentage of the serum levels of the sham group. *p<0.05 for the values of the low-dose or high-dose curcumin group compared with that of untreated ovariectomy (OVX) group, †p<0.05 for the values of the high-dose curcumin group compared with that of low-dose curcumin group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921272&req=5

Figure 2: Graphs showing the serum levels of osteocalcin (A), alkaline phosphatase (ALP) (B), and type I collagen C-telopeptide (CTX-1) (C). Values are expressed as percentage of the serum levels of the sham group. *p<0.05 for the values of the low-dose or high-dose curcumin group compared with that of untreated ovariectomy (OVX) group, †p<0.05 for the values of the high-dose curcumin group compared with that of low-dose curcumin group.
Mentions: Fig. 2A, B show the serum levels of the bone formation biochemical markers, osteocalcin and ALP, and Fig. 2C shows the serum levels of CTX-1, which is a sensitive marker of bone resorption. Results have been expressed as percentage of the serum levels of the biochemical markers of the sham group.

Bottom Line: High-dose curcumin group showed significantly lower osteocalcin, alkaline phosphatase, and the telopeptide fragment of type I collagen C-terminus concentration at 4 and 8 weeks compared with the untreated OVX group as well as low-dose curcumin group.Only high-dose curcumin treated group had a significant increase of mechanical strength compared with the untreated OVX group (p=0.015).The present study results demonstrat that a high-dose curcumin has therapeutic advantages over a low-dose curcumin of an antiresorptive effect on bone remodeling and improving bone mechanical strength.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, School of Medicine, Kyungpook National University, Daegu, Korea.

ABSTRACT

Objective: Although curcumin has a protective effect on bone remodeling, appropriate therapeutic concentrations of curcumin are not well known as therapeutic drugs for osteoporosis. The purpose of this study was to compare the bone sparing effect of treatment of low-dose and high-dose curcumin after ovariectomy in rats.

Methods: Forty female Sprague-Dawley rats underwent either a sham operation (the sham group) or bilateral ovariectomy (OVX). The ovariectomized animals were randomly distributed among three groups; untreated OVX group, low-dose (10 mg/kg) curcumin administered group, and high-dose (50 mg/kg) curcumin group. At 4 and 8 weeks after surgery, serum biochemical markers of bone turnover were analyzed. Bone histomorphometric parameters of the 4th lumbar vertebrae were determined by micro-computed tomography (CT). In addition, mechanical strength was determined by a three-point bending test.

Results: High-dose curcumin group showed significantly lower osteocalcin, alkaline phosphatase, and the telopeptide fragment of type I collagen C-terminus concentration at 4 and 8 weeks compared with the untreated OVX group as well as low-dose curcumin group. In the analyses of micro-CT scans of 4th lumbar vertebrae, the high-dose curcumin treated group showed a significant increase in bone mineral densities (p=0.028) and cortical bone mineral densities (p=0.036) compared with the low-dose curcumin treated group. Only high-dose curcumin treated group had a significant increase of mechanical strength compared with the untreated OVX group (p=0.015).

Conclusion: The present study results demonstrat that a high-dose curcumin has therapeutic advantages over a low-dose curcumin of an antiresorptive effect on bone remodeling and improving bone mechanical strength.

No MeSH data available.


Related in: MedlinePlus