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Systemic effects of wood smoke in a short-term experimental exposure study of atopic volunteers.

Bønløkke JH, Riddervold IS, Grønborg TK, Skogstrand K, Hougaard DM, Barregard L, Sigsgaard T - J. Occup. Environ. Med. (2014)

Bottom Line: Data were analyzed with mixed models.Few differences in the outcomes were observed.Interleukin-6 increased after filtered air (P = 0.03).

View Article: PubMed Central - PubMed

Affiliation: From the Section of Environment Work and Health (Drs Bønløkke, Riddervold, and Sigsgaard), Institute of Public Health, University of Aarhus, Aarhus, Denmark; Section of Biostatistics (Ms Grønborg), Institute of Public Health, University of Aarhus, Aarhus, Denmark; Department of Clinical Biochemistry and Immunology (Drs Skogstrand and Hougaard), Statens Serum Institut, Copenhagen, Denmark; and Department of Occupational and Environmental Medicine (Dr Barregard), Sahlgrenska University Hospital and Academy, University of Gothenburg, Gothenburg, Sweden.

ABSTRACT

Objective: To investigate whether short-term systemic effects of wood smoke occurred in atopic subjects after experimental wood smoke exposures.

Methods: A double-blind climate chamber study was conducted on 20 healthy atopic subjects with exposures to filtered air and wood smoke. Pneumoproteins, coagulation and adhesion factors, and cytokines were measured. Heart rate was monitored with pulse monitors. Data were analyzed with mixed models.

Results: Few differences in the outcomes were observed. Plasma tissue factor remained elevated during filtered air exposure (P = 0.002). P-selectin declined independent of exposure (P = 0.0006). Interleukin-6 increased after filtered air (P = 0.03).

Conclusions: The study confirmed previous observations among nonatopics of limited changes after a 3-hour wood smoke exposure.

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Related in: MedlinePlus

Plasma sP-selectin. Means of the ln-transformed plasma sP-selectin concentrations at baseline, and 0, 6, and 20 hours after the three exposures to filtered air, low, and high concentrations of wood smoke. Error bars represent +1 standard deviation.
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Figure 2: Plasma sP-selectin. Means of the ln-transformed plasma sP-selectin concentrations at baseline, and 0, 6, and 20 hours after the three exposures to filtered air, low, and high concentrations of wood smoke. Error bars represent +1 standard deviation.

Mentions: The plasma TF varied statistically significant between the three exposures (P = 0.002). As shown in Fig. 1, the TF was statistically significant higher during the filtered air exposure than during the low and high concentration wood smoke exposures (P = 0.03 and 0.0005, respectively). Nevertheless, a P value of 0.38 for a time–exposure interaction indicated that the difference between the exposures did not change with time (ie, it was present already before the smoke exposure was initiated). Plasma sP-selectin, as can be seen in Fig. 2, declined with time (P = 0.0006). The concentration of sP-selectin was statistically significant higher at baseline compared with 0 hours (P = 0.0002) and 6 hours (P = 0.0009) but not 20 hours after exposure (P = 0.61). The P value for a time–exposure interaction was 0.66, thus indicating that the difference in sP-selectin between the exposures did not change with time. No statistically significant changes were observed in sE-selectin or VWF:Ag.


Systemic effects of wood smoke in a short-term experimental exposure study of atopic volunteers.

Bønløkke JH, Riddervold IS, Grønborg TK, Skogstrand K, Hougaard DM, Barregard L, Sigsgaard T - J. Occup. Environ. Med. (2014)

Plasma sP-selectin. Means of the ln-transformed plasma sP-selectin concentrations at baseline, and 0, 6, and 20 hours after the three exposures to filtered air, low, and high concentrations of wood smoke. Error bars represent +1 standard deviation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921260&req=5

Figure 2: Plasma sP-selectin. Means of the ln-transformed plasma sP-selectin concentrations at baseline, and 0, 6, and 20 hours after the three exposures to filtered air, low, and high concentrations of wood smoke. Error bars represent +1 standard deviation.
Mentions: The plasma TF varied statistically significant between the three exposures (P = 0.002). As shown in Fig. 1, the TF was statistically significant higher during the filtered air exposure than during the low and high concentration wood smoke exposures (P = 0.03 and 0.0005, respectively). Nevertheless, a P value of 0.38 for a time–exposure interaction indicated that the difference between the exposures did not change with time (ie, it was present already before the smoke exposure was initiated). Plasma sP-selectin, as can be seen in Fig. 2, declined with time (P = 0.0006). The concentration of sP-selectin was statistically significant higher at baseline compared with 0 hours (P = 0.0002) and 6 hours (P = 0.0009) but not 20 hours after exposure (P = 0.61). The P value for a time–exposure interaction was 0.66, thus indicating that the difference in sP-selectin between the exposures did not change with time. No statistically significant changes were observed in sE-selectin or VWF:Ag.

Bottom Line: Data were analyzed with mixed models.Few differences in the outcomes were observed.Interleukin-6 increased after filtered air (P = 0.03).

View Article: PubMed Central - PubMed

Affiliation: From the Section of Environment Work and Health (Drs Bønløkke, Riddervold, and Sigsgaard), Institute of Public Health, University of Aarhus, Aarhus, Denmark; Section of Biostatistics (Ms Grønborg), Institute of Public Health, University of Aarhus, Aarhus, Denmark; Department of Clinical Biochemistry and Immunology (Drs Skogstrand and Hougaard), Statens Serum Institut, Copenhagen, Denmark; and Department of Occupational and Environmental Medicine (Dr Barregard), Sahlgrenska University Hospital and Academy, University of Gothenburg, Gothenburg, Sweden.

ABSTRACT

Objective: To investigate whether short-term systemic effects of wood smoke occurred in atopic subjects after experimental wood smoke exposures.

Methods: A double-blind climate chamber study was conducted on 20 healthy atopic subjects with exposures to filtered air and wood smoke. Pneumoproteins, coagulation and adhesion factors, and cytokines were measured. Heart rate was monitored with pulse monitors. Data were analyzed with mixed models.

Results: Few differences in the outcomes were observed. Plasma tissue factor remained elevated during filtered air exposure (P = 0.002). P-selectin declined independent of exposure (P = 0.0006). Interleukin-6 increased after filtered air (P = 0.03).

Conclusions: The study confirmed previous observations among nonatopics of limited changes after a 3-hour wood smoke exposure.

Show MeSH
Related in: MedlinePlus