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Preclinical screening for retinopathy of prematurity risk using IGF1 levels at 3 weeks post-partum.

Pérez-Muñuzuri A, Couce-Pico ML, Baña-Souto A, López-Suárez O, Iglesias-Deus A, Blanco-Teijeiro J, Fernández-Lorenzo JR, Fraga-Bermúdez JM - PLoS ONE (2014)

Bottom Line: Following current recommendations for preventing retinopathy of prematurity (ROP) involves screening a large number of patients.A significant association was found between the development of retinopathy and each of the following variables: early gestational age, low birthweight, requiring mechanical ventilation, oxygen treatment, intracranial haemorrhage, sepsis during the first three weeks, bronchopulmonary dysplasia, the need for erythrocyte transfusion, erythropoietin treatment, and low levels of serum IGF1 in the third week.Such preclinical screening has the ability to identify patients with high-risk of developing retinopathy and should lead to better prediction for ROP, while at the same time optimising the use of clinical resources, both human and material.

View Article: PubMed Central - PubMed

Affiliation: Neonatology Service, Department of Paediatrics, Clinical Hospital of the University of Santiago de Compostela, Santiago de Compostela, Spain.

ABSTRACT
Following current recommendations for preventing retinopathy of prematurity (ROP) involves screening a large number of patients. We performed a prospective study to establish a useful screening system for ROP prediction and we have determined that measuring serum levels of IGF1 at week three and the presence of sepsis have a high predictive value for the subsequent development of ROP. A total of 145 premature newborn, with birthweight <1500 g and/or <32 weeks gestational age, were enrolled. 26.9% of them showed some form of retinopathy. A significant association was found between the development of retinopathy and each of the following variables: early gestational age, low birthweight, requiring mechanical ventilation, oxygen treatment, intracranial haemorrhage, sepsis during the first three weeks, bronchopulmonary dysplasia, the need for erythrocyte transfusion, erythropoietin treatment, and low levels of serum IGF1 in the third week. A multiple logistic regression analysis was used to obtain curves for the probability of developing ROP, based on the main factors linked with ROP, namely serum levels of IGF1 and presence of sepsis. Such preclinical screening has the ability to identify patients with high-risk of developing retinopathy and should lead to better prediction for ROP, while at the same time optimising the use of clinical resources, both human and material.

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Related in: MedlinePlus

IGF1 levels (Y-axes) dispersion at third week related with the weight gain (X-axes) in the first three weeks of life.
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pone-0088781-g001: IGF1 levels (Y-axes) dispersion at third week related with the weight gain (X-axes) in the first three weeks of life.

Mentions: We evaluated the weight gain during the first 3 weeks of life and was correlated with IGF1 levels at third week of life (Figure 1).


Preclinical screening for retinopathy of prematurity risk using IGF1 levels at 3 weeks post-partum.

Pérez-Muñuzuri A, Couce-Pico ML, Baña-Souto A, López-Suárez O, Iglesias-Deus A, Blanco-Teijeiro J, Fernández-Lorenzo JR, Fraga-Bermúdez JM - PLoS ONE (2014)

IGF1 levels (Y-axes) dispersion at third week related with the weight gain (X-axes) in the first three weeks of life.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921187&req=5

pone-0088781-g001: IGF1 levels (Y-axes) dispersion at third week related with the weight gain (X-axes) in the first three weeks of life.
Mentions: We evaluated the weight gain during the first 3 weeks of life and was correlated with IGF1 levels at third week of life (Figure 1).

Bottom Line: Following current recommendations for preventing retinopathy of prematurity (ROP) involves screening a large number of patients.A significant association was found between the development of retinopathy and each of the following variables: early gestational age, low birthweight, requiring mechanical ventilation, oxygen treatment, intracranial haemorrhage, sepsis during the first three weeks, bronchopulmonary dysplasia, the need for erythrocyte transfusion, erythropoietin treatment, and low levels of serum IGF1 in the third week.Such preclinical screening has the ability to identify patients with high-risk of developing retinopathy and should lead to better prediction for ROP, while at the same time optimising the use of clinical resources, both human and material.

View Article: PubMed Central - PubMed

Affiliation: Neonatology Service, Department of Paediatrics, Clinical Hospital of the University of Santiago de Compostela, Santiago de Compostela, Spain.

ABSTRACT
Following current recommendations for preventing retinopathy of prematurity (ROP) involves screening a large number of patients. We performed a prospective study to establish a useful screening system for ROP prediction and we have determined that measuring serum levels of IGF1 at week three and the presence of sepsis have a high predictive value for the subsequent development of ROP. A total of 145 premature newborn, with birthweight <1500 g and/or <32 weeks gestational age, were enrolled. 26.9% of them showed some form of retinopathy. A significant association was found between the development of retinopathy and each of the following variables: early gestational age, low birthweight, requiring mechanical ventilation, oxygen treatment, intracranial haemorrhage, sepsis during the first three weeks, bronchopulmonary dysplasia, the need for erythrocyte transfusion, erythropoietin treatment, and low levels of serum IGF1 in the third week. A multiple logistic regression analysis was used to obtain curves for the probability of developing ROP, based on the main factors linked with ROP, namely serum levels of IGF1 and presence of sepsis. Such preclinical screening has the ability to identify patients with high-risk of developing retinopathy and should lead to better prediction for ROP, while at the same time optimising the use of clinical resources, both human and material.

Show MeSH
Related in: MedlinePlus