Limits...
Tc17 cells in patients with uterine cervical cancer.

Zhang Y, Hou F, Liu X, Ma D, Zhang Y, Kong B, Cui B - PLoS ONE (2014)

Bottom Line: Besides, the increased level of Tc17 in UCC patients was associated with the status of pelvic lymph node metastases and increased microvessel density.Finally, significant correlations of infiltration between Tc17 cells and Th17 cells or Foxp3-expressing T cells were observed in UCC and CIN tissues.This study indicates that Tc17 cell infiltration in cervical cancers is associated with cancer progression accompanied by increased infiltrations of Th17 cells and regulatory T cells as well as promoted tumor vasculogenesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China ; Department of Obstetrics and Gynecology, People's Hospital, Weifang City, Shandong, People's Republic of China ; Gynecology Oncology Key Library of Shandong Province, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China.

ABSTRACT

Background: The existence of Tc17 cells was recently shown in several types of infectious and autoimmune diseases, but their distribution and functions in uterine cervical cancer (UCC) have not been fully elucidated.

Methods: The frequency of Tc17 cells in peripheral blood samples obtained from UCC patients, cervical intraepithelial neoplasia (CIN) patients and healthy controls was determined by flow cytometry. Besides, the prevalence of Tc17 cells and their relationships to Th17 cells and Foxp3-expressing T cells as well as microvessels in tissue samples of the patients were assessed by immunohistochemistry staining.

Results: Compared to controls, patients with UCC or CIN had a higher proportion of Tc17 cells in both peripheral blood and cervical tissues, but the level of Tc17 cells in UCC tissues was significantly higher than that in CIN tissues. Besides, the increased level of Tc17 in UCC patients was associated with the status of pelvic lymph node metastases and increased microvessel density. Finally, significant correlations of infiltration between Tc17 cells and Th17 cells or Foxp3-expressing T cells were observed in UCC and CIN tissues.

Conclusions: This study indicates that Tc17 cell infiltration in cervical cancers is associated with cancer progression accompanied by increased infiltrations of Th17 cells and regulatory T cells as well as promoted tumor vasculogenesis.

Show MeSH

Related in: MedlinePlus

The correlations between Tc17 cells and Th17 cells.(a, b) Linear regression analysis between frequencies of Tc17 cell and Th17 cells in the blood (rCIN = 0.435, P = 0.042, n = 22; rUCC = 0.403, P = 0.016, n = 36). (c, d) Linear regression analysis between the levels of Tc17 cells and Th17 cells in the cervical tissues (rCIN = 0.441, P = 0.039, n = 17; rUCC = 0.693, P = 0.026, n = 30).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3921122&req=5

pone-0086812-g006: The correlations between Tc17 cells and Th17 cells.(a, b) Linear regression analysis between frequencies of Tc17 cell and Th17 cells in the blood (rCIN = 0.435, P = 0.042, n = 22; rUCC = 0.403, P = 0.016, n = 36). (c, d) Linear regression analysis between the levels of Tc17 cells and Th17 cells in the cervical tissues (rCIN = 0.441, P = 0.039, n = 17; rUCC = 0.693, P = 0.026, n = 30).

Mentions: Since Tc17 cells are similar to Th17 cells in the respect of developmental pathway and possible effects [23], [24], it is reasonable to investigate the relation between them. The primary data and the methods for Th17 cells detection in the same three groups (UCC, CIN and the control groups) were shown in our two previous published papers [8], [25]. The results demonstrated that the levels of Th17 cells and Tc17 cells were positively correlated in the CIN and UCC groups in both peripheral blood (rCIN = 0.435, P = 0.042; rUCC = 0.403, P = 0.016) (Fig. 6 a and b) and cervical tissues (rCIN = 0.441, P = 0.039; rUCC = 0.693, P = 0.026) (Fig. 6 c and d).


Tc17 cells in patients with uterine cervical cancer.

Zhang Y, Hou F, Liu X, Ma D, Zhang Y, Kong B, Cui B - PLoS ONE (2014)

The correlations between Tc17 cells and Th17 cells.(a, b) Linear regression analysis between frequencies of Tc17 cell and Th17 cells in the blood (rCIN = 0.435, P = 0.042, n = 22; rUCC = 0.403, P = 0.016, n = 36). (c, d) Linear regression analysis between the levels of Tc17 cells and Th17 cells in the cervical tissues (rCIN = 0.441, P = 0.039, n = 17; rUCC = 0.693, P = 0.026, n = 30).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921122&req=5

pone-0086812-g006: The correlations between Tc17 cells and Th17 cells.(a, b) Linear regression analysis between frequencies of Tc17 cell and Th17 cells in the blood (rCIN = 0.435, P = 0.042, n = 22; rUCC = 0.403, P = 0.016, n = 36). (c, d) Linear regression analysis between the levels of Tc17 cells and Th17 cells in the cervical tissues (rCIN = 0.441, P = 0.039, n = 17; rUCC = 0.693, P = 0.026, n = 30).
Mentions: Since Tc17 cells are similar to Th17 cells in the respect of developmental pathway and possible effects [23], [24], it is reasonable to investigate the relation between them. The primary data and the methods for Th17 cells detection in the same three groups (UCC, CIN and the control groups) were shown in our two previous published papers [8], [25]. The results demonstrated that the levels of Th17 cells and Tc17 cells were positively correlated in the CIN and UCC groups in both peripheral blood (rCIN = 0.435, P = 0.042; rUCC = 0.403, P = 0.016) (Fig. 6 a and b) and cervical tissues (rCIN = 0.441, P = 0.039; rUCC = 0.693, P = 0.026) (Fig. 6 c and d).

Bottom Line: Besides, the increased level of Tc17 in UCC patients was associated with the status of pelvic lymph node metastases and increased microvessel density.Finally, significant correlations of infiltration between Tc17 cells and Th17 cells or Foxp3-expressing T cells were observed in UCC and CIN tissues.This study indicates that Tc17 cell infiltration in cervical cancers is associated with cancer progression accompanied by increased infiltrations of Th17 cells and regulatory T cells as well as promoted tumor vasculogenesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China ; Department of Obstetrics and Gynecology, People's Hospital, Weifang City, Shandong, People's Republic of China ; Gynecology Oncology Key Library of Shandong Province, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China.

ABSTRACT

Background: The existence of Tc17 cells was recently shown in several types of infectious and autoimmune diseases, but their distribution and functions in uterine cervical cancer (UCC) have not been fully elucidated.

Methods: The frequency of Tc17 cells in peripheral blood samples obtained from UCC patients, cervical intraepithelial neoplasia (CIN) patients and healthy controls was determined by flow cytometry. Besides, the prevalence of Tc17 cells and their relationships to Th17 cells and Foxp3-expressing T cells as well as microvessels in tissue samples of the patients were assessed by immunohistochemistry staining.

Results: Compared to controls, patients with UCC or CIN had a higher proportion of Tc17 cells in both peripheral blood and cervical tissues, but the level of Tc17 cells in UCC tissues was significantly higher than that in CIN tissues. Besides, the increased level of Tc17 in UCC patients was associated with the status of pelvic lymph node metastases and increased microvessel density. Finally, significant correlations of infiltration between Tc17 cells and Th17 cells or Foxp3-expressing T cells were observed in UCC and CIN tissues.

Conclusions: This study indicates that Tc17 cell infiltration in cervical cancers is associated with cancer progression accompanied by increased infiltrations of Th17 cells and regulatory T cells as well as promoted tumor vasculogenesis.

Show MeSH
Related in: MedlinePlus