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Possible association between haplotypes of the FKBP5 gene and suicidal bipolar disorder, but not with melancholic depression and psychotic features, in the course of bipolar disorder.

Leszczyńska-Rodziewicz A, Szczepankiewicz A, Narożna B, Skibińska M, Pawlak J, Dmitrzak-Węglarz M, Hauser J - Neuropsychiatr Dis Treat (2014)

Bottom Line: We found weak association between the haplotypes of the FKBP5 gene and bipolar patients with suicidal attempts.We did not find an association between polymorphisms of the FKBP5 gene and bipolar disorder with psychotic features, nor with bipolar disorder with melancholic depression.Limitations of our study are the absence of data about previous trauma exposure and the small sample size of patients, which of course can lead to false-positive results, so further validation and replication of the present findings are still needed.

View Article: PubMed Central - PubMed

Affiliation: Psychiatric Genetics Unit, Poznań University of Medical Sciences, Poznań, Poland.

ABSTRACT
We aimed to analyzed the association between polymorphisms of the FKBP5 (FK506 binding protein 5) gene and subtypes of bipolar disorder. In the study, we included 195 bipolar disorder patients with psychotic features, 129 bipolar patients with melancholic depression, and 156 bipolar patients with a history of suicidal attempts. We found weak association between the haplotypes of the FKBP5 gene and bipolar patients with suicidal attempts. We did not find an association between polymorphisms of the FKBP5 gene and bipolar disorder with psychotic features, nor with bipolar disorder with melancholic depression. Limitations of our study are the absence of data about previous trauma exposure and the small sample size of patients, which of course can lead to false-positive results, so further validation and replication of the present findings are still needed.

No MeSH data available.


Related in: MedlinePlus

Relative positions and LD estimates between FKBP5 polymorphisms in the analyzed population-patients with melancholic depression.Note: Colored squares correspond to D’ values with numerical estimates given within the squares.
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f1-ndt-10-243: Relative positions and LD estimates between FKBP5 polymorphisms in the analyzed population-patients with melancholic depression.Note: Colored squares correspond to D’ values with numerical estimates given within the squares.

Mentions: We found association with haplotypes CCATTGT (P=0.0123) and CCACTAT (P=0.0235) in bipolar patients with suicidal attempts, but not in bipolar patients with melancholic depression and not with bipolar patients with psychotic features (shown in Table 3 and Figures 1–3). We did not find any associations with genotypes (data not shown) nor with alleles (shown in Table 4) for the studied polymorphisms.


Possible association between haplotypes of the FKBP5 gene and suicidal bipolar disorder, but not with melancholic depression and psychotic features, in the course of bipolar disorder.

Leszczyńska-Rodziewicz A, Szczepankiewicz A, Narożna B, Skibińska M, Pawlak J, Dmitrzak-Węglarz M, Hauser J - Neuropsychiatr Dis Treat (2014)

Relative positions and LD estimates between FKBP5 polymorphisms in the analyzed population-patients with melancholic depression.Note: Colored squares correspond to D’ values with numerical estimates given within the squares.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3921086&req=5

f1-ndt-10-243: Relative positions and LD estimates between FKBP5 polymorphisms in the analyzed population-patients with melancholic depression.Note: Colored squares correspond to D’ values with numerical estimates given within the squares.
Mentions: We found association with haplotypes CCATTGT (P=0.0123) and CCACTAT (P=0.0235) in bipolar patients with suicidal attempts, but not in bipolar patients with melancholic depression and not with bipolar patients with psychotic features (shown in Table 3 and Figures 1–3). We did not find any associations with genotypes (data not shown) nor with alleles (shown in Table 4) for the studied polymorphisms.

Bottom Line: We found weak association between the haplotypes of the FKBP5 gene and bipolar patients with suicidal attempts.We did not find an association between polymorphisms of the FKBP5 gene and bipolar disorder with psychotic features, nor with bipolar disorder with melancholic depression.Limitations of our study are the absence of data about previous trauma exposure and the small sample size of patients, which of course can lead to false-positive results, so further validation and replication of the present findings are still needed.

View Article: PubMed Central - PubMed

Affiliation: Psychiatric Genetics Unit, Poznań University of Medical Sciences, Poznań, Poland.

ABSTRACT
We aimed to analyzed the association between polymorphisms of the FKBP5 (FK506 binding protein 5) gene and subtypes of bipolar disorder. In the study, we included 195 bipolar disorder patients with psychotic features, 129 bipolar patients with melancholic depression, and 156 bipolar patients with a history of suicidal attempts. We found weak association between the haplotypes of the FKBP5 gene and bipolar patients with suicidal attempts. We did not find an association between polymorphisms of the FKBP5 gene and bipolar disorder with psychotic features, nor with bipolar disorder with melancholic depression. Limitations of our study are the absence of data about previous trauma exposure and the small sample size of patients, which of course can lead to false-positive results, so further validation and replication of the present findings are still needed.

No MeSH data available.


Related in: MedlinePlus