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Diagnostic Approaches to Sjögren's syndrome: a Literature Review and Own Clinical Experience.

Gomes Pde S, Juodzbalys G, Fernandes MH, Guobis Z - J Oral Maxillofac Res (2012)

Bottom Line: Eligible studies were identified by searching the electronic literature PubMed, Medline, Embase, and ScienceDirect databases for relevant reports (last search update January 2012) combining the MESH heading term "Sjögren's syndrome", with the words "diagnosis, diagnostic procedures, salivary gland function, ocular tests, histopathology, salivary gland imaging, serology".The authors checked the references of the selected articles to identify additional eligible publications and contacted the authors, if necessary.Due to its systemic involvement, it can exhibit a wide range of clinical manifestations that contribute to confusion and delay in diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Laboratory of Pharmacology and Cellular Biocompatibility, Faculty of Dental Medicine, University of Porto Porto Portugal.

ABSTRACT

Objectives: The purpose of present paper is to critically address the recent advances on diagnostic procedures of Sjögren's syndrome, taking into account the attained local and systemic features of the disease.

Material and methods: A comprehensive review of the available literature regarding to the diagnostic approaches to Sjögren's syndrome was conducted. Eligible studies were identified by searching the electronic literature PubMed, Medline, Embase, and ScienceDirect databases for relevant reports (last search update January 2012) combining the MESH heading term "Sjögren's syndrome", with the words "diagnosis, diagnostic procedures, salivary gland function, ocular tests, histopathology, salivary gland imaging, serology". The authors checked the references of the selected articles to identify additional eligible publications and contacted the authors, if necessary.

Results: Presented article addresses the established diagnostic criteria for Sjögren's syndrome and critically evaluates the most commonly used diagnostic procedures, presenting data from author's own clinical experience. Diagnostic criteria for Sjögren's syndrome are required both by healthcare professionals and patients, namely in order to provide a rational basis for the assessment of the symptoms, establish an individual disease prognosis, and orientate the therapeutic intervention.

Conclusions: Sjögren's syndrome is quite a common autoimmune disease of which the diagnosis and treatment are not easily established. Due to its systemic involvement, it can exhibit a wide range of clinical manifestations that contribute to confusion and delay in diagnosis. The use of proper diagnostic modalities will help to reduce the time to diagnosis and preserve the health and quality of life of patients with Sjögren's syndrome.

No MeSH data available.


Related in: MedlinePlus

STI test (A) and test results (B) revealing a significant reduction inlachrymal secretion.
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fig1: STI test (A) and test results (B) revealing a significant reduction inlachrymal secretion.

Mentions: In STI, the strip is placed in the lower fornix between the medial and lateral thirdof the eyelid of the unanaesthetised eye. After 5 minutes, the amount of wetting ismeasured from the extrafornical position of the strip [10]. According to both the Revised International ClassificationCriteria for Sjögren's syndrome and the Japanese criteria, if less than 5 mm ofpaper are wetted following 5 minutes of the STI test, the result of the test isconsidered positive. In Figure 1, the STItest and its results, conducted on a SS-affected individual, are shown.


Diagnostic Approaches to Sjögren's syndrome: a Literature Review and Own Clinical Experience.

Gomes Pde S, Juodzbalys G, Fernandes MH, Guobis Z - J Oral Maxillofac Res (2012)

STI test (A) and test results (B) revealing a significant reduction inlachrymal secretion.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3886093&req=5

fig1: STI test (A) and test results (B) revealing a significant reduction inlachrymal secretion.
Mentions: In STI, the strip is placed in the lower fornix between the medial and lateral thirdof the eyelid of the unanaesthetised eye. After 5 minutes, the amount of wetting ismeasured from the extrafornical position of the strip [10]. According to both the Revised International ClassificationCriteria for Sjögren's syndrome and the Japanese criteria, if less than 5 mm ofpaper are wetted following 5 minutes of the STI test, the result of the test isconsidered positive. In Figure 1, the STItest and its results, conducted on a SS-affected individual, are shown.

Bottom Line: Eligible studies were identified by searching the electronic literature PubMed, Medline, Embase, and ScienceDirect databases for relevant reports (last search update January 2012) combining the MESH heading term "Sjögren's syndrome", with the words "diagnosis, diagnostic procedures, salivary gland function, ocular tests, histopathology, salivary gland imaging, serology".The authors checked the references of the selected articles to identify additional eligible publications and contacted the authors, if necessary.Due to its systemic involvement, it can exhibit a wide range of clinical manifestations that contribute to confusion and delay in diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Laboratory of Pharmacology and Cellular Biocompatibility, Faculty of Dental Medicine, University of Porto Porto Portugal.

ABSTRACT

Objectives: The purpose of present paper is to critically address the recent advances on diagnostic procedures of Sjögren's syndrome, taking into account the attained local and systemic features of the disease.

Material and methods: A comprehensive review of the available literature regarding to the diagnostic approaches to Sjögren's syndrome was conducted. Eligible studies were identified by searching the electronic literature PubMed, Medline, Embase, and ScienceDirect databases for relevant reports (last search update January 2012) combining the MESH heading term "Sjögren's syndrome", with the words "diagnosis, diagnostic procedures, salivary gland function, ocular tests, histopathology, salivary gland imaging, serology". The authors checked the references of the selected articles to identify additional eligible publications and contacted the authors, if necessary.

Results: Presented article addresses the established diagnostic criteria for Sjögren's syndrome and critically evaluates the most commonly used diagnostic procedures, presenting data from author's own clinical experience. Diagnostic criteria for Sjögren's syndrome are required both by healthcare professionals and patients, namely in order to provide a rational basis for the assessment of the symptoms, establish an individual disease prognosis, and orientate the therapeutic intervention.

Conclusions: Sjögren's syndrome is quite a common autoimmune disease of which the diagnosis and treatment are not easily established. Due to its systemic involvement, it can exhibit a wide range of clinical manifestations that contribute to confusion and delay in diagnosis. The use of proper diagnostic modalities will help to reduce the time to diagnosis and preserve the health and quality of life of patients with Sjögren's syndrome.

No MeSH data available.


Related in: MedlinePlus