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Formulation and in vitro characterization of xanthan gum-based sustained release matrix tables of isosorbide-5- mononitrate.

Kar R, Mohapatra S, Bhanja S, Das D, Barik B - Iran J Pharm Res (2010)

Bottom Line: In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate.Thus, xanthan gum can be used as an effective matrix former to extend the release of isosorbide-5-mononitrate.No significant difference was observed in the dissolution profile of optimized formulation, using basket and paddle apparatus.

View Article: PubMed Central - PubMed

Affiliation: Jeypore College of Pharmacy, Jeypore, Koraput, India.

ABSTRACT
In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. Sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in F1 (1:0.75), F2 (1:1), F3 (1:1.5), F4 (1:1.75) and F6 (1:2). Xanthan gum was used as matrix former and microcrystalline cellulose as diluent. All the lubricated formulations were compressed, using 8mm flat faced punches. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, in vitro dissolution study using basket method and swelling index. Each formulation showed compliance with pharmacopoeial standards. Among all formulations, F5 showed a greater sustained release pattern of drug over a 12 h period with 92.12% of drug being released. The kinetic studies showed that drug release follows the Higuchi model (r(2) =0.9851). Korsemeyer and Peppas equation gave an n-value of 0.4566, which was close to 0.5, indicating that drug release follows the Fickian diffusion. Thus, xanthan gum can be used as an effective matrix former to extend the release of isosorbide-5-mononitrate. No significant difference was observed in the dissolution profile of optimized formulation, using basket and paddle apparatus.

No MeSH data available.


Related in: MedlinePlus

Comparative dissolution study of the optimized formulation F5, using the basket and paddle apparatus (n = 6, mean ± SD).
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Figure 6: Comparative dissolution study of the optimized formulation F5, using the basket and paddle apparatus (n = 6, mean ± SD).

Mentions: at 50 rpm (Figure 6). It was observed that tablets present within the buffer solution, settled down to the bottom of the flask. It swelled considerably to release drug from the matrix. There was no significant difference between the basket and paddle method, under the same experimental condition (P > 0.05), when data were analyzed using one way ANOVA (Sigma Stat 3.5 software).


Formulation and in vitro characterization of xanthan gum-based sustained release matrix tables of isosorbide-5- mononitrate.

Kar R, Mohapatra S, Bhanja S, Das D, Barik B - Iran J Pharm Res (2010)

Comparative dissolution study of the optimized formulation F5, using the basket and paddle apparatus (n = 6, mean ± SD).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3869548&req=5

Figure 6: Comparative dissolution study of the optimized formulation F5, using the basket and paddle apparatus (n = 6, mean ± SD).
Mentions: at 50 rpm (Figure 6). It was observed that tablets present within the buffer solution, settled down to the bottom of the flask. It swelled considerably to release drug from the matrix. There was no significant difference between the basket and paddle method, under the same experimental condition (P > 0.05), when data were analyzed using one way ANOVA (Sigma Stat 3.5 software).

Bottom Line: In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate.Thus, xanthan gum can be used as an effective matrix former to extend the release of isosorbide-5-mononitrate.No significant difference was observed in the dissolution profile of optimized formulation, using basket and paddle apparatus.

View Article: PubMed Central - PubMed

Affiliation: Jeypore College of Pharmacy, Jeypore, Koraput, India.

ABSTRACT
In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. Sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in F1 (1:0.75), F2 (1:1), F3 (1:1.5), F4 (1:1.75) and F6 (1:2). Xanthan gum was used as matrix former and microcrystalline cellulose as diluent. All the lubricated formulations were compressed, using 8mm flat faced punches. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, in vitro dissolution study using basket method and swelling index. Each formulation showed compliance with pharmacopoeial standards. Among all formulations, F5 showed a greater sustained release pattern of drug over a 12 h period with 92.12% of drug being released. The kinetic studies showed that drug release follows the Higuchi model (r(2) =0.9851). Korsemeyer and Peppas equation gave an n-value of 0.4566, which was close to 0.5, indicating that drug release follows the Fickian diffusion. Thus, xanthan gum can be used as an effective matrix former to extend the release of isosorbide-5-mononitrate. No significant difference was observed in the dissolution profile of optimized formulation, using basket and paddle apparatus.

No MeSH data available.


Related in: MedlinePlus