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Formulation and in vitro characterization of xanthan gum-based sustained release matrix tables of isosorbide-5- mononitrate.

Kar R, Mohapatra S, Bhanja S, Das D, Barik B - Iran J Pharm Res (2010)

Bottom Line: In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate.Thus, xanthan gum can be used as an effective matrix former to extend the release of isosorbide-5-mononitrate.No significant difference was observed in the dissolution profile of optimized formulation, using basket and paddle apparatus.

View Article: PubMed Central - PubMed

Affiliation: Jeypore College of Pharmacy, Jeypore, Koraput, India.

ABSTRACT
In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. Sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in F1 (1:0.75), F2 (1:1), F3 (1:1.5), F4 (1:1.75) and F6 (1:2). Xanthan gum was used as matrix former and microcrystalline cellulose as diluent. All the lubricated formulations were compressed, using 8mm flat faced punches. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, in vitro dissolution study using basket method and swelling index. Each formulation showed compliance with pharmacopoeial standards. Among all formulations, F5 showed a greater sustained release pattern of drug over a 12 h period with 92.12% of drug being released. The kinetic studies showed that drug release follows the Higuchi model (r(2) =0.9851). Korsemeyer and Peppas equation gave an n-value of 0.4566, which was close to 0.5, indicating that drug release follows the Fickian diffusion. Thus, xanthan gum can be used as an effective matrix former to extend the release of isosorbide-5-mononitrate. No significant difference was observed in the dissolution profile of optimized formulation, using basket and paddle apparatus.

No MeSH data available.


Related in: MedlinePlus

Effect of the speed of rotation on dissolution profile of the optimized formulation F5 (n = 6, mean ± SD).
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Figure 5: Effect of the speed of rotation on dissolution profile of the optimized formulation F5 (n = 6, mean ± SD).

Mentions: A positive influence of speed of rotation during the in vitro drug release study was noted (Figure 5). As the stirring speed was increased, the thickness of the hydrated gelatinous layer surrounding the intact tablet core was noticeably decreased, resulting in a more rapid release of drug from the tablet matrix. The was also reported by Talukdar et al (22).


Formulation and in vitro characterization of xanthan gum-based sustained release matrix tables of isosorbide-5- mononitrate.

Kar R, Mohapatra S, Bhanja S, Das D, Barik B - Iran J Pharm Res (2010)

Effect of the speed of rotation on dissolution profile of the optimized formulation F5 (n = 6, mean ± SD).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3869548&req=5

Figure 5: Effect of the speed of rotation on dissolution profile of the optimized formulation F5 (n = 6, mean ± SD).
Mentions: A positive influence of speed of rotation during the in vitro drug release study was noted (Figure 5). As the stirring speed was increased, the thickness of the hydrated gelatinous layer surrounding the intact tablet core was noticeably decreased, resulting in a more rapid release of drug from the tablet matrix. The was also reported by Talukdar et al (22).

Bottom Line: In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate.Thus, xanthan gum can be used as an effective matrix former to extend the release of isosorbide-5-mononitrate.No significant difference was observed in the dissolution profile of optimized formulation, using basket and paddle apparatus.

View Article: PubMed Central - PubMed

Affiliation: Jeypore College of Pharmacy, Jeypore, Koraput, India.

ABSTRACT
In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. Sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in F1 (1:0.75), F2 (1:1), F3 (1:1.5), F4 (1:1.75) and F6 (1:2). Xanthan gum was used as matrix former and microcrystalline cellulose as diluent. All the lubricated formulations were compressed, using 8mm flat faced punches. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, in vitro dissolution study using basket method and swelling index. Each formulation showed compliance with pharmacopoeial standards. Among all formulations, F5 showed a greater sustained release pattern of drug over a 12 h period with 92.12% of drug being released. The kinetic studies showed that drug release follows the Higuchi model (r(2) =0.9851). Korsemeyer and Peppas equation gave an n-value of 0.4566, which was close to 0.5, indicating that drug release follows the Fickian diffusion. Thus, xanthan gum can be used as an effective matrix former to extend the release of isosorbide-5-mononitrate. No significant difference was observed in the dissolution profile of optimized formulation, using basket and paddle apparatus.

No MeSH data available.


Related in: MedlinePlus