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Evaluation of dextrose water, black tea and orange juice on histopathologic recovery of surgery-induced intestinal damage in rabbits.

Hosseinpour M, Ehteram H, Farhadi M, Behdad S - Trauma Mon (2012)

Bottom Line: Morphologic data were compared in groups.There was a significant difference in villi lengths in the groups (P = 0.003).Orange juice as a source of vitamin C may be an appropriate liquid for postoperative recovery following intestinal surgery.

View Article: PubMed Central - PubMed

Affiliation: Trauma Research Center, Kashan University of Medical Sciences, Kashan, IR Iran.

ABSTRACT

Background: The increase in intestinal permeability following damage to the intestinal mucosa in any surgical procedure, trauma or fasting is well- known.

Objectives: Our objective was to experimentally evaluate whether antioxidant consumption is associated with decreased intestinal damage in intestinal surgical procedures.

Materials and methods: Forty rabbits were used to compare the pathological changes in the intestine after consumption of dextrose water 5% (D5W), black tea and orange juice in fasting and in cases with intestine resection and anastomosis. They were divided in to five groups as shams (GI), NPO (G II), D5W (GIII), black tea (GIV) and orange juice groups (GV). In GII to GV group with median laparotomy, a 2 cm segment of jejunum was resected and ends of the bowel were anastomosed. Postoperatively, animals fasted for five days. Animals in GII were killed after five days of fasting. On day five case groups were given free access to drinking D5w (GIII), black tea solution (G IV) and orange juice (GV) for a further 7 days. On day 8, animals were reoperated and the repaired segment of intestine was removed. Morphologic data were compared in groups.

Results: There were 8 rabbits in each group. There was a significant difference in villi lengths in the groups (P = 0.003). GV rabbits had obvious recovery of the villous architecture.

Conclusions: Orange juice as a source of vitamin C may be an appropriate liquid for postoperative recovery following intestinal surgery.

No MeSH data available.


Related in: MedlinePlus

Histologic changes in the intestinal mucosa during the recovery period in GII (NPO)
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fig619: Histologic changes in the intestinal mucosa during the recovery period in GII (NPO)

Mentions: Table 1 shows the lengths of the villi in the groups. There was a significant difference in villi lengths in the groups (P = 0.003). In comparison with GI (Figure 1), in all of other groups (Figures 2, 3, 4 and 5), the number of goblet cells were decreased. Infiltration of inflammatory cells and lymphangectasia, villi fragmentation and crypt wideness also increased in case and control groups. In comparison to control group (GII) with experimental groups we found that villous changes, inflammatory cells infiltration and goblet cells reduction were more prominent in unfed rabbits. In comparison of case groups, villous change and inflammatory cell infiltration were more prominent in GIII and GIV. On the other hand GV rabbits had obvious recovery of the villous architecture. In comparison of GIII and GIV, we found that inflammatory cells infiltration was more prominent in G4 group.


Evaluation of dextrose water, black tea and orange juice on histopathologic recovery of surgery-induced intestinal damage in rabbits.

Hosseinpour M, Ehteram H, Farhadi M, Behdad S - Trauma Mon (2012)

Histologic changes in the intestinal mucosa during the recovery period in GII (NPO)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3860643&req=5

fig619: Histologic changes in the intestinal mucosa during the recovery period in GII (NPO)
Mentions: Table 1 shows the lengths of the villi in the groups. There was a significant difference in villi lengths in the groups (P = 0.003). In comparison with GI (Figure 1), in all of other groups (Figures 2, 3, 4 and 5), the number of goblet cells were decreased. Infiltration of inflammatory cells and lymphangectasia, villi fragmentation and crypt wideness also increased in case and control groups. In comparison to control group (GII) with experimental groups we found that villous changes, inflammatory cells infiltration and goblet cells reduction were more prominent in unfed rabbits. In comparison of case groups, villous change and inflammatory cell infiltration were more prominent in GIII and GIV. On the other hand GV rabbits had obvious recovery of the villous architecture. In comparison of GIII and GIV, we found that inflammatory cells infiltration was more prominent in G4 group.

Bottom Line: Morphologic data were compared in groups.There was a significant difference in villi lengths in the groups (P = 0.003).Orange juice as a source of vitamin C may be an appropriate liquid for postoperative recovery following intestinal surgery.

View Article: PubMed Central - PubMed

Affiliation: Trauma Research Center, Kashan University of Medical Sciences, Kashan, IR Iran.

ABSTRACT

Background: The increase in intestinal permeability following damage to the intestinal mucosa in any surgical procedure, trauma or fasting is well- known.

Objectives: Our objective was to experimentally evaluate whether antioxidant consumption is associated with decreased intestinal damage in intestinal surgical procedures.

Materials and methods: Forty rabbits were used to compare the pathological changes in the intestine after consumption of dextrose water 5% (D5W), black tea and orange juice in fasting and in cases with intestine resection and anastomosis. They were divided in to five groups as shams (GI), NPO (G II), D5W (GIII), black tea (GIV) and orange juice groups (GV). In GII to GV group with median laparotomy, a 2 cm segment of jejunum was resected and ends of the bowel were anastomosed. Postoperatively, animals fasted for five days. Animals in GII were killed after five days of fasting. On day five case groups were given free access to drinking D5w (GIII), black tea solution (G IV) and orange juice (GV) for a further 7 days. On day 8, animals were reoperated and the repaired segment of intestine was removed. Morphologic data were compared in groups.

Results: There were 8 rabbits in each group. There was a significant difference in villi lengths in the groups (P = 0.003). GV rabbits had obvious recovery of the villous architecture.

Conclusions: Orange juice as a source of vitamin C may be an appropriate liquid for postoperative recovery following intestinal surgery.

No MeSH data available.


Related in: MedlinePlus