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Alcohol's role in HIV transmission and disease progression.

Pandrea I, Happel KI, Amedee AM, Bagby GJ, Nelson S - Alcohol Res Health (2010)

Bottom Line: Alcohol use has negative effects on HIV disease progression through several mechanisms, including transmission, viral replication, host immunity, and treatment efficacy.Research with animal models has explored the effect of alcohol intake on several aspects of simian immunodeficiency virus (SIV) disease progression.Further studies using the animal model are necessary.

View Article: PubMed Central - PubMed

Affiliation: University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

ABSTRACT
Alcohol use has negative effects on HIV disease progression through several mechanisms, including transmission, viral replication, host immunity, and treatment efficacy. Research with animal models has explored the effect of alcohol intake on several aspects of simian immunodeficiency virus (SIV) disease progression. Data suggest that the increased SIV levels observed in alcohol-consuming animals may represent an increase in virus production as opposed to a decrease in host defense. Results also suggest that changes in nutritional balance and metabolism, as a possible consequence of a proinflammatory state, together with increased virus production in animals consuming alcohol, accelerate SIV and possibly HIV disease progression. Further studies using the animal model are necessary.

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Overall impact of alcohol consumption on human immunodeficiency virus (HIV) pathogenesis.
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f1-arh-33-3-203: Overall impact of alcohol consumption on human immunodeficiency virus (HIV) pathogenesis.

Mentions: Given the high prevalence of substance abuse in the HIV population, deciphering the effects of alcohol and other drugs on HIV transmission, disease progression, and treatment response is a high research priority. This article will review evidence showing that excessive alcohol consumption is detrimental to the HIV-infected patient in several aspects (see figure 1). Topics discussed include the effect of alcohol abuse on HIV transmission, viral replication, host immune system, and efficacy of treatment to keep HIV levels low (i.e., antiretroviral [ARV] therapy [ART]). The article also will present data showing the effect of alcohol intake on simian immunodeficiency virus (SIV) pathogenesis in rhesus macaques, the animal model of choice for HIV infection. Finally, the article will discuss potential research avenues in nonhuman primate (NHP) animal models that can be used to further our understanding of the role of the alcohol in the natural history of acquired immune deficiency syndrome (AIDS).


Alcohol's role in HIV transmission and disease progression.

Pandrea I, Happel KI, Amedee AM, Bagby GJ, Nelson S - Alcohol Res Health (2010)

Overall impact of alcohol consumption on human immunodeficiency virus (HIV) pathogenesis.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3860502&req=5

f1-arh-33-3-203: Overall impact of alcohol consumption on human immunodeficiency virus (HIV) pathogenesis.
Mentions: Given the high prevalence of substance abuse in the HIV population, deciphering the effects of alcohol and other drugs on HIV transmission, disease progression, and treatment response is a high research priority. This article will review evidence showing that excessive alcohol consumption is detrimental to the HIV-infected patient in several aspects (see figure 1). Topics discussed include the effect of alcohol abuse on HIV transmission, viral replication, host immune system, and efficacy of treatment to keep HIV levels low (i.e., antiretroviral [ARV] therapy [ART]). The article also will present data showing the effect of alcohol intake on simian immunodeficiency virus (SIV) pathogenesis in rhesus macaques, the animal model of choice for HIV infection. Finally, the article will discuss potential research avenues in nonhuman primate (NHP) animal models that can be used to further our understanding of the role of the alcohol in the natural history of acquired immune deficiency syndrome (AIDS).

Bottom Line: Alcohol use has negative effects on HIV disease progression through several mechanisms, including transmission, viral replication, host immunity, and treatment efficacy.Research with animal models has explored the effect of alcohol intake on several aspects of simian immunodeficiency virus (SIV) disease progression.Further studies using the animal model are necessary.

View Article: PubMed Central - PubMed

Affiliation: University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

ABSTRACT
Alcohol use has negative effects on HIV disease progression through several mechanisms, including transmission, viral replication, host immunity, and treatment efficacy. Research with animal models has explored the effect of alcohol intake on several aspects of simian immunodeficiency virus (SIV) disease progression. Data suggest that the increased SIV levels observed in alcohol-consuming animals may represent an increase in virus production as opposed to a decrease in host defense. Results also suggest that changes in nutritional balance and metabolism, as a possible consequence of a proinflammatory state, together with increased virus production in animals consuming alcohol, accelerate SIV and possibly HIV disease progression. Further studies using the animal model are necessary.

Show MeSH
Related in: MedlinePlus